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• W2901003838 abstract "Our previous study revealed that an antimicrobial peptide hepcidin, can be significantly up-regulated either with LPS challenge or upon exposure to Benzo[a]pyrene (BaP) in red sea bream, but the molecular mechanism involved in whether the transcriptional expression of hepcidin induced by LPS or BaP is regulated through a similar signaling pathway is not yet known. To elucidate the underlying molecular mechanism, the marine model fish Oryzias melastigma was exposed to 1 μg/L BaP as well as challenged with 5 μg of LPS per fish. Samples at 3 h post-LPS challenge, and 2 d and 3 d post-BaP exposure were separately collected for transcriptome analysis. General analysis of the predicted immune-associated unigenes based on the transcriptomic data showed that the percentages of modulated immune-associated genes were 7% with LPS challenge, and 3% and 7% with BaP exposure at 2 and 3 days, respectively. Genes involved in functions like antimicrobial activity, neutrophil activation, and leukocyte chemotaxis were up-regulated with LPS challenge, whereas more than half of the immune associated genes including the KLF family were down-regulated upon BaP exposure, indicating a difference in the modulated immune genes between LPS challenge and BaP exposure. Specific comparative analyses of the immune-associated signal pathways NOD, TOLL, NF-κB and JAK-STAT with LPS challenge or upon exposure to BaP, indicated that most of the modulated genes in association with the NOD, TOLL and NF-κB pathways were induced with LPS challenge but only a few after exposure to BaP, suggesting that BaP exposure was generally not associated with any of the three signal pathways. Interestingly, further transcriptomic analysis revealed that 5 of the 8 modulated genes associated with the JAK-STAT pathway were down-regulated, while 2 inhibiting genes were up-regulated after BaP exposure for 2 days whereas LPS challenge resulted in only less than half modulated, suggesting the possibility of down-regulation caused by BaP exposure through JAK-STAT pathway. Further testing using an EPC cell culture demonstrated that expression of the hepcidin1 gene was less involved in the known signal pathways, such as c/EBP, BMP, and NF-κB, but instead mostly in association with the JAK-STAT pathway upon BaP exposure." @default.
• W2901003838 created "2018-11-29" @default.
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• W2901003838 date "2019-01-01" @default.
• W2901003838 modified "2023-10-17" @default.
• W2901003838 title "Transcriptomic analysis revealing hepcidin expression in Oryzias melastigma regulated through the JAK-STAT signaling pathway upon exposure to BaP" @default.
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• W2901003838 doi "https://doi.org/10.1016/j.aquatox.2018.11.015" @default.
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