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- W2901030853 endingPage "106" @default.
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- W2901030853 abstract "Up to 6.1 million people in the United States have atrial fibrillation (AF), which is associated with an increased risk of stroke. Oral anticoagulants are the mainstay of stroke prevention in AF. For decades, warfarin was the only available drug, fraught with compliance limitations, a narrow therapeutic window, and a high risk of hemorrhage. Pharmacologic developments have produced new anticoagulants that have improved the rates of stroke related to AF; however, they still confer a high risk of bleeding, making them unsuitable for some patients. Studies have shown that roughly 90% of strokes in patients with AF occur in the left atrial appendage (LAA). This understanding has prompted the development and testing of novel percutaneous strategies for LAA closure as an alternative to anticoagulation therapy. The following review examines the relative merits and shortcomings of these strategies and explores future prospects in the prevention of AF-related stroke." @default.
- W2901030853 created "2018-11-29" @default.
- W2901030853 creator A5038751555 @default.
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- W2901030853 date "2017-07-01" @default.
- W2901030853 modified "2023-09-23" @default.
- W2901030853 title "Approaches to Left Atrial Appendage Closure: Device Design, Performance, and Limitations" @default.
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- W2901030853 doi "https://doi.org/10.14797/mdcj-13-3-106" @default.
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