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- W2901036660 endingPage "R71" @default.
- W2901036660 startingPage "R59" @default.
- W2901036660 abstract "The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine system that regulates appetite and body weight. Fluctuating leptin levels provide molecular signals to the brain regarding available energy reserves modulating energy homeostasis and neuroendocrine response in states of leptin deficiency and to a lesser extent in hyperleptinemic states. While leptin replacement therapy fails to provide substantial benefit in common obesity, it is an effective treatment for congenital leptin deficiency and states of acquired leptin deficiency such as lipodystrophy. Current evidence suggests that regulation of eating behavior in humans is not limited to homeostatic mechanisms and that the reward, attention, memory and emotion systems are involved, participating in a complex central nervous system network. It is critical to study these systems for the treatment of typical obesity. Although progress has been made, further studies are required to unravel the physiology, pathophysiology and neurobehavioral mechanisms underlying potential treatments for weight-related problems in humans." @default.
- W2901036660 created "2018-11-29" @default.
- W2901036660 creator A5005766189 @default.
- W2901036660 creator A5008453405 @default.
- W2901036660 creator A5051390220 @default.
- W2901036660 creator A5087370577 @default.
- W2901036660 date "2019-02-01" @default.
- W2901036660 modified "2023-10-02" @default.
- W2901036660 title "GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans" @default.
- W2901036660 cites W117206723 @default.
- W2901036660 cites W122522238 @default.
- W2901036660 cites W1499189927 @default.
- W2901036660 cites W1505713219 @default.
- W2901036660 cites W1608498692 @default.
- W2901036660 cites W1639930240 @default.
- W2901036660 cites W1653273172 @default.
- W2901036660 cites W1966218936 @default.
- W2901036660 cites W1969576589 @default.
- W2901036660 cites W1969621876 @default.
- W2901036660 cites W1972062612 @default.
- W2901036660 cites W1973102414 @default.
- W2901036660 cites W1973543642 @default.
- W2901036660 cites W1974256272 @default.
- W2901036660 cites W1974316717 @default.
- W2901036660 cites W1976329330 @default.
- W2901036660 cites W1976723938 @default.
- W2901036660 cites W1977283476 @default.
- W2901036660 cites W1984053203 @default.
- W2901036660 cites W1985263940 @default.
- W2901036660 cites W1985475058 @default.
- W2901036660 cites W1985528328 @default.
- W2901036660 cites W1985870045 @default.
- W2901036660 cites W1987376546 @default.
- W2901036660 cites W1987470586 @default.
- W2901036660 cites W1988876904 @default.
- W2901036660 cites W1988947995 @default.
- W2901036660 cites W1989388706 @default.
- W2901036660 cites W1990407738 @default.
- W2901036660 cites W1993413620 @default.
- W2901036660 cites W1994545264 @default.
- W2901036660 cites W1995026750 @default.
- W2901036660 cites W1996713062 @default.
- W2901036660 cites W1996958355 @default.
- W2901036660 cites W1997157145 @default.
- W2901036660 cites W2006949877 @default.
- W2901036660 cites W2007125731 @default.
- W2901036660 cites W2007482590 @default.
- W2901036660 cites W2012820882 @default.
- W2901036660 cites W2015130768 @default.
- W2901036660 cites W2017774316 @default.
- W2901036660 cites W2020803051 @default.
- W2901036660 cites W2021052947 @default.
- W2901036660 cites W2024706154 @default.
- W2901036660 cites W2024794762 @default.
- W2901036660 cites W2025295789 @default.
- W2901036660 cites W2025846514 @default.
- W2901036660 cites W2027112907 @default.
- W2901036660 cites W2030183538 @default.
- W2901036660 cites W2030553376 @default.
- W2901036660 cites W2031250543 @default.
- W2901036660 cites W2033503688 @default.
- W2901036660 cites W2033804399 @default.
- W2901036660 cites W2043551756 @default.
- W2901036660 cites W2048160943 @default.
- W2901036660 cites W2050183238 @default.
- W2901036660 cites W2053321990 @default.
- W2901036660 cites W2053426841 @default.
- W2901036660 cites W2055956383 @default.
- W2901036660 cites W2056871375 @default.
- W2901036660 cites W2057528564 @default.
- W2901036660 cites W2057629453 @default.
- W2901036660 cites W2057788834 @default.
- W2901036660 cites W2059105920 @default.
- W2901036660 cites W2061769753 @default.
- W2901036660 cites W2062336804 @default.
- W2901036660 cites W2063048904 @default.
- W2901036660 cites W2067168283 @default.
- W2901036660 cites W2068275172 @default.
- W2901036660 cites W2070013078 @default.
- W2901036660 cites W2070139973 @default.
- W2901036660 cites W2073828263 @default.
- W2901036660 cites W2076377925 @default.
- W2901036660 cites W2076601892 @default.
- W2901036660 cites W2079643489 @default.
- W2901036660 cites W2085461391 @default.
- W2901036660 cites W2086970589 @default.
- W2901036660 cites W2089495913 @default.
- W2901036660 cites W2091087465 @default.
- W2901036660 cites W2095566802 @default.
- W2901036660 cites W2096329739 @default.
- W2901036660 cites W2098025594 @default.
- W2901036660 cites W2098162750 @default.
- W2901036660 cites W2101680331 @default.
- W2901036660 cites W2103270369 @default.
- W2901036660 cites W2111843622 @default.
- W2901036660 cites W2111913226 @default.
- W2901036660 cites W2115839432 @default.
- W2901036660 cites W2118769775 @default.