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• W2901046089 endingPage "4990" @default.
• W2901046089 startingPage "4978" @default.
• W2901046089 abstract "Animal species are able to acquire new genetic material via hybridization and subsequent introgression. However, little is known about how foreign genomic material is incorporated into a population over time and what genes are susceptible to introgression. Here, we follow the closely related mosquito sister species Anopheles coluzzii and Anopheles gambiae in a sympatric natural population in Mali at multiple time points spanning a period of 25 years. During this period, we observed the temporary breakdown of mating barriers, which allowed us to explore the fate of alleles that crossed the species boundary in a natural population. Whole genome sequencing of 74 individuals revealed introgression within only 34 genes (0.26% of total genes) from A. gambiae to A. coluzzii, the majority contained within a 4 Mb region on the 2L chromosome which includes the insecticide resistance gene (AGAP004707). We designed a genotyping assay to follow 25 of the 34 introgressed alleles over time and found that all A. gambiae alleles, except four, reached a frequency of 50% in the A. coluzzii population within 4 years (~50 generations) and increased to ~80% within 6 years (~75 generations). However, the frequency of all introgressed alleles, except three, decreased to ~60% in 2016. This suggests an ongoing process of purifying selection in the population against DNA of foreign ancestry, except for alleles that are under positive selection, resulting in a complex genomic landscape. This study shows that stable introgression is limited to only specific genes even within closely related species." @default.
• W2901046089 created "2018-11-29" @default.
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• W2901046089 date "2018-12-01" @default.
• W2901046089 modified "2023-09-26" @default.
• W2901046089 title "The fate of genes that cross species boundaries after a major hybridization event in a natural mosquito population" @default.
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• W2901046089 doi "https://doi.org/10.1111/mec.14947" @default.
• W2901046089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30447117" @default.
• W2901046089 hasPublicationYear "2018" @default.
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