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• W2901050714 endingPage "119" @default.
• W2901050714 startingPage "106" @default.
• W2901050714 abstract "To characterize mechanisms involved in neurokinin type 1 receptor (NK1R)-mediated emesis, we investigated the brainstem emetic signaling pathways following treating least shrews with the selective NK1R agonist GR73632. In addition to episodes of vomiting over a 30-min observation period, a significant increase in substance P-immunoreactivity in the emetic brainstem dorsal motor nucleus of the vagus (DMNX) occurred at 15 min post an intraperitoneal (i.p.) injection GR73632 (5 mg/kg). In addition, time-dependent upregulation of phosphorylation of several emesis -associated protein kinases occurred in the brainstem. In fact, Western blots demonstrated significant phosphorylations of Ca2+/calmodulin kinase IIα (CaMKIIα), extracellular signal-regulated protein kinase1/2 (ERK1/2), protein kinase B (Akt) as well as α and βII isoforms of protein kinase C (PKCα/βII). Moreover, enhanced phospho-ERK1/2 immunoreactivity was also observed in both brainstem slices containing the dorsal vagal complex emetic nuclei as well as in jejunal sections from the shrew small intestine. Furthermore, our behavioral findings demonstrated that the following agents suppressed vomiting evoked by GR73632 in a dose-dependent manner: i) the NK1R antagonist netupitant (i.p.); ii) the L-type Ca2+ channel (LTCC) antagonist nifedipine (subcutaneous, s.c.); iii) the inositol trisphosphate receptor (IP3R) antagonist 2-APB (i.p.); iv) store-operated Ca2+ entry inhibitors YM-58483 and MRS-1845, (i.p.); v) the ERK1/2 pathway inhibitor U0126 (i.p.); vi) the PKC inhibitor GF109203X (i.p.); and vii) the inhibitor of phosphatidylinositol 3-kinase (PI3K)-Akt pathway LY294002 (i.p.). Moreover, NK1R, LTCC, and IP3R are required for GR73632-evoked CaMKIIα, ERK1/2, Akt and PKCα/βII phosphorylation. In addition, evoked ERK1/2 phosphorylation was sensitive to inhibitors of PKC and PI3K. These findings indicate that the LTCC/IP3R-dependent PI3K/PKCα/βII-ERK1/2 signaling pathways are involved in NK1R-mediated vomiting." @default.
• W2901050714 created "2018-11-29" @default.
• W2901050714 creator A5005520140 @default.
• W2901050714 creator A5021654371 @default.
• W2901050714 creator A5077927694 @default.
• W2901050714 date "2019-01-01" @default.
• W2901050714 modified "2023-10-18" @default.
• W2901050714 title "Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NK1R) agonist GR73632 evokes vomiting in the least shrew (Cryptotis parva)" @default.
• W2901050714 cites W116128053 @default.
• W2901050714 cites W1599368877 @default.
• W2901050714 cites W1755018410 @default.
• W2901050714 cites W1817224593 @default.
• W2901050714 cites W1825928607 @default.
• W2901050714 cites W1942906531 @default.
• W2901050714 cites W1963862264 @default.
• W2901050714 cites W1966040667 @default.
• W2901050714 cites W1971770050 @default.
• W2901050714 cites W1972015024 @default.
• W2901050714 cites W1974232104 @default.
• W2901050714 cites W1977648495 @default.
• W2901050714 cites W1985620421 @default.
• W2901050714 cites W1986519853 @default.
• W2901050714 cites W1988045624 @default.
• W2901050714 cites W1989525287 @default.
• W2901050714 cites W1990736267 @default.
• W2901050714 cites W1995549680 @default.
• W2901050714 cites W1999523285 @default.
• W2901050714 cites W2003638272 @default.
• W2901050714 cites W2004049140 @default.
• W2901050714 cites W2005339341 @default.
• W2901050714 cites W2005373033 @default.
• W2901050714 cites W2005846556 @default.
• W2901050714 cites W2007133692 @default.
• W2901050714 cites W2008385868 @default.
• W2901050714 cites W2014169505 @default.
• W2901050714 cites W2014788236 @default.
• W2901050714 cites W2015208756 @default.
• W2901050714 cites W2016348702 @default.
• W2901050714 cites W2020493895 @default.
• W2901050714 cites W2023696362 @default.
• W2901050714 cites W2025677698 @default.
• W2901050714 cites W2025828871 @default.
• W2901050714 cites W2028562160 @default.
• W2901050714 cites W2030964340 @default.
• W2901050714 cites W2031786331 @default.
• W2901050714 cites W2034854862 @default.
• W2901050714 cites W2036145275 @default.
• W2901050714 cites W2039758575 @default.
• W2901050714 cites W2041677049 @default.
• W2901050714 cites W2043236514 @default.
• W2901050714 cites W2045487778 @default.
• W2901050714 cites W2047463238 @default.
• W2901050714 cites W2049561003 @default.
• W2901050714 cites W2050609356 @default.
• W2901050714 cites W2052152709 @default.
• W2901050714 cites W2055948011 @default.
• W2901050714 cites W2058272715 @default.
• W2901050714 cites W2059013280 @default.
• W2901050714 cites W2059194215 @default.
• W2901050714 cites W2061406577 @default.
• W2901050714 cites W2064226629 @default.
• W2901050714 cites W2072472358 @default.
• W2901050714 cites W2073626626 @default.
• W2901050714 cites W2076641476 @default.
• W2901050714 cites W2077549265 @default.
• W2901050714 cites W2081308078 @default.
• W2901050714 cites W2082583113 @default.
• W2901050714 cites W2082848438 @default.
• W2901050714 cites W2086089999 @default.
• W2901050714 cites W2086376316 @default.
• W2901050714 cites W2087393893 @default.
• W2901050714 cites W2087443236 @default.
• W2901050714 cites W2090472806 @default.
• W2901050714 cites W2092450619 @default.
• W2901050714 cites W2102409261 @default.
• W2901050714 cites W2113561204 @default.
• W2901050714 cites W2118444707 @default.
• W2901050714 cites W2119499251 @default.
• W2901050714 cites W2120121064 @default.
• W2901050714 cites W2130077303 @default.
• W2901050714 cites W2137258759 @default.
• W2901050714 cites W2137788707 @default.
• W2901050714 cites W2140647939 @default.
• W2901050714 cites W214629270 @default.
• W2901050714 cites W2151808454 @default.
• W2901050714 cites W2153631445 @default.
• W2901050714 cites W2155440673 @default.
• W2901050714 cites W2165395427 @default.
• W2901050714 cites W2184350636 @default.
• W2901050714 cites W2278989323 @default.
• W2901050714 cites W2410574953 @default.
• W2901050714 cites W2410637171 @default.
• W2901050714 cites W2410894392 @default.
• W2901050714 cites W2412096695 @default.
• W2901050714 cites W2507937111 @default.
• W2901050714 cites W2512492485 @default.
• W2901050714 cites W2766199217 @default.
• W2901050714 doi "https://doi.org/10.1016/j.neuint.2018.11.012" @default.

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