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• W2901064422 abstract "Objectives The aim of this study was to clarify by histopathological examination the origin of oral membranous substances deposited on the palate, tongue, buccal mucosa and teeth. Background Several investigators have reported membranous substances deposited in the mouths of bedridden elderly persons requiring nursing care without oral intake. However, the precise nature and origin of the substances are poorly understood. Methods Sixty‐nine specimens were taken from the oral cavity of bedridden patients, that is, the palate, dorsum of the tongue, the cheek and teeth. Sections were stained with haematoxylin and eosin stain, alcian‐blue and periodic acid‐Schiff stain (AB‐PAS) and antibodies for pankeratin (AE1AE3) and leukocyte common antigen (LCA). Results All specimens showed a film‐like nature coloured from tan to white, accompanied by a mucous substance. Histologically, specimens of all sites had a similar feature of the combination of basophilic amorphous and eosinophilic lamellar features. The basophilic substance was positive for AB‐PAS, and PAS‐positive glycogen granules were also noted in the lamellar structure. Immunochemistry revealed various degrees of pankeratin positive substance and LCA‐positive inflammatory cell infiltration. Conclusion The oral membranous substance was composed of keratin and mucin with inflammation. These results suggest that the deposition of the oral membranous substance is a pathological condition or oral mucositis caused by dry mouth." @default.
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• W2901064422 date "2018-11-20" @default.
• W2901064422 modified "2023-10-12" @default.
• W2901064422 title "Histopathological evaluation of oral membranous substance in bedridden elderly persons without oral intake in Japan" @default.
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• W2901064422 doi "https://doi.org/10.1111/ger.12379" @default.
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