Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901090060> ?p ?o ?g. }
- W2901090060 endingPage "770" @default.
- W2901090060 startingPage "764" @default.
- W2901090060 abstract "Abstract Background : Major depressive disorder (MDD) is a prevalent neuropsychiatric disease that carries a staggering global burden. Although numerous antidepressants are available on the market, unfortunately, many patients die by committing suicide as a result of the therapeutic lag between treatment initiation and the improvement of depressive symptoms. This therapeutic lag highlights the need for new antidepressants that provide rapid relief of depressive symptoms. Method : In this review, we discuss the seminal researches on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in animal models of depression and highlight the substantial evidence supporting the development of rapid-acting antidepressants targeting HCN channels. Results : HCN channels are associated with the risk of depression and targeting HCN channels or its auxiliary subunit tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) function may exert a rapid antidepressant-like effect. Conclusions : Compounds acting on HCN subunits or the TRIP8b–HCN interaction site may be excellent candidates for development into effective drugs with rapid antidepressant action." @default.
- W2901090060 created "2018-11-29" @default.
- W2901090060 creator A5008824959 @default.
- W2901090060 creator A5056036725 @default.
- W2901090060 creator A5066451986 @default.
- W2901090060 date "2019-02-01" @default.
- W2901090060 modified "2023-09-26" @default.
- W2901090060 title "HCN channels: New targets for the design of an antidepressant with rapid effects" @default.
- W2901090060 cites W1877874306 @default.
- W2901090060 cites W1966343623 @default.
- W2901090060 cites W1966516510 @default.
- W2901090060 cites W1969373823 @default.
- W2901090060 cites W1969679106 @default.
- W2901090060 cites W1980782420 @default.
- W2901090060 cites W1980938183 @default.
- W2901090060 cites W1981097208 @default.
- W2901090060 cites W1981654563 @default.
- W2901090060 cites W1985663331 @default.
- W2901090060 cites W1990323943 @default.
- W2901090060 cites W1993360833 @default.
- W2901090060 cites W1993545434 @default.
- W2901090060 cites W1994609215 @default.
- W2901090060 cites W1995556701 @default.
- W2901090060 cites W2005871900 @default.
- W2901090060 cites W2007379387 @default.
- W2901090060 cites W2012579750 @default.
- W2901090060 cites W2013575118 @default.
- W2901090060 cites W2014095642 @default.
- W2901090060 cites W2014880992 @default.
- W2901090060 cites W2014897728 @default.
- W2901090060 cites W2019247974 @default.
- W2901090060 cites W2023327890 @default.
- W2901090060 cites W2028499304 @default.
- W2901090060 cites W2028786180 @default.
- W2901090060 cites W2028980996 @default.
- W2901090060 cites W2034633663 @default.
- W2901090060 cites W2036372135 @default.
- W2901090060 cites W2036638644 @default.
- W2901090060 cites W2040650224 @default.
- W2901090060 cites W2042240426 @default.
- W2901090060 cites W2042726169 @default.
- W2901090060 cites W2043887334 @default.
- W2901090060 cites W2046218208 @default.
- W2901090060 cites W2047649641 @default.
- W2901090060 cites W2053956493 @default.
- W2901090060 cites W2054498084 @default.
- W2901090060 cites W2057374715 @default.
- W2901090060 cites W2057717270 @default.
- W2901090060 cites W2058867280 @default.
- W2901090060 cites W2060978653 @default.
- W2901090060 cites W2064165921 @default.
- W2901090060 cites W2066406363 @default.
- W2901090060 cites W2068982474 @default.
- W2901090060 cites W2070093918 @default.
- W2901090060 cites W2072298966 @default.
- W2901090060 cites W2072531628 @default.
- W2901090060 cites W2076054524 @default.
- W2901090060 cites W2077401778 @default.
- W2901090060 cites W2082919951 @default.
- W2901090060 cites W2084681734 @default.
- W2901090060 cites W2086725413 @default.
- W2901090060 cites W2088177395 @default.
- W2901090060 cites W2089351762 @default.
- W2901090060 cites W2102650234 @default.
- W2901090060 cites W2104293622 @default.
- W2901090060 cites W2108212317 @default.
- W2901090060 cites W2108337682 @default.
- W2901090060 cites W2108432043 @default.
- W2901090060 cites W2113391699 @default.
- W2901090060 cites W2117782909 @default.
- W2901090060 cites W2121972943 @default.
- W2901090060 cites W2124203952 @default.
- W2901090060 cites W2127069730 @default.
- W2901090060 cites W2137004506 @default.
- W2901090060 cites W2139970636 @default.
- W2901090060 cites W2144177683 @default.
- W2901090060 cites W2148622919 @default.
- W2901090060 cites W2151476315 @default.
- W2901090060 cites W2151488696 @default.
- W2901090060 cites W2157325758 @default.
- W2901090060 cites W2161201932 @default.
- W2901090060 cites W2169124033 @default.
- W2901090060 cites W2171502806 @default.
- W2901090060 cites W2259239391 @default.
- W2901090060 cites W2285926604 @default.
- W2901090060 cites W2286609955 @default.
- W2901090060 cites W2291443053 @default.
- W2901090060 cites W2295989183 @default.
- W2901090060 cites W2314705006 @default.
- W2901090060 cites W2336977282 @default.
- W2901090060 cites W2346390990 @default.
- W2901090060 cites W2392835602 @default.
- W2901090060 cites W2407137898 @default.
- W2901090060 cites W2408529313 @default.
- W2901090060 cites W2411013142 @default.
- W2901090060 cites W2415443438 @default.
- W2901090060 cites W2465471481 @default.
- W2901090060 cites W2484912492 @default.