Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901101732> ?p ?o ?g. }
- W2901101732 abstract "Ischemia-reperfusion (I/R) is a common cause of acute kidney injury (AKI), which is associated with high mortality and poor outcomes. Autophagy plays important roles in the homeostasis of renal tubular cells (RTCs) and is implicated in the pathogenesis of AKI, although its role in the process is complex and controversial. Fibroblast growth factor 10 (FGF10), a multifunctional FGF family member, was reported to exert protective effect against cerebral ischemia injury and myocardial damage. Whether FGF10 has similar beneficial effect, and if so whether autophagy is associated with the potential protective activity against AKI has not been investigated. Herein, we report that FGF10 treatment improved renal function and histological integrity in a rat model of renal I/R injury. We observed that FGF10 efficiently reduced I/R-induced elevation in blood urea nitrogen, serum creatinine as well as apoptosis induction of RTCs. Interestingly, autophagy activation following I/R was suppressed by FGF10 treatment based on the immunohistochemistry staining and immunoblot analyses of LC3, Beclin-1 and SQSTM1/p62. Moreover, combined treatment of FGF10 with Rapamycin partially reversed the renoprotective effect of FGF10 suggesting the involvement of mTOR pathway in the process. Interestingly, FGF10 also inhibited the release of HMGB1 from the nucleus to the extracellular domain and regulated the expression of inflammatory cytokines such as TNF-α, IL-1β and IL-6. Together, these results indicate that FGF10 could alleviate kidney I/R injury by suppressing excessive autophagy and inhibiting inflammatory response and may therefore have the potential to be used for the prevention and perhaps treatment of I/R-associated AKI." @default.
- W2901101732 created "2018-11-29" @default.
- W2901101732 creator A5003989193 @default.
- W2901101732 creator A5014656305 @default.
- W2901101732 creator A5028696869 @default.
- W2901101732 creator A5037320344 @default.
- W2901101732 creator A5044548791 @default.
- W2901101732 creator A5048721439 @default.
- W2901101732 creator A5051511582 @default.
- W2901101732 creator A5064285851 @default.
- W2901101732 creator A5074458217 @default.
- W2901101732 creator A5077230882 @default.
- W2901101732 creator A5085567767 @default.
- W2901101732 date "2018-11-23" @default.
- W2901101732 modified "2023-10-18" @default.
- W2901101732 title "FGF10 Protects Against Renal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammatory Signaling" @default.
- W2901101732 cites W1516311606 @default.
- W2901101732 cites W1814069918 @default.
- W2901101732 cites W1821112462 @default.
- W2901101732 cites W1905126559 @default.
- W2901101732 cites W1964536962 @default.
- W2901101732 cites W1966498811 @default.
- W2901101732 cites W1970680333 @default.
- W2901101732 cites W1971799714 @default.
- W2901101732 cites W1974766032 @default.
- W2901101732 cites W1980381580 @default.
- W2901101732 cites W1985124617 @default.
- W2901101732 cites W1986081276 @default.
- W2901101732 cites W1986912320 @default.
- W2901101732 cites W1987115582 @default.
- W2901101732 cites W1992076733 @default.
- W2901101732 cites W1992532731 @default.
- W2901101732 cites W1996846107 @default.
- W2901101732 cites W2003059814 @default.
- W2901101732 cites W2012371191 @default.
- W2901101732 cites W2016040396 @default.
- W2901101732 cites W2018653121 @default.
- W2901101732 cites W2026500266 @default.
- W2901101732 cites W2027239974 @default.
- W2901101732 cites W2030835500 @default.
- W2901101732 cites W2031308048 @default.
- W2901101732 cites W204998232 @default.
- W2901101732 cites W2052470191 @default.
- W2901101732 cites W2052831640 @default.
- W2901101732 cites W2059738518 @default.
- W2901101732 cites W2067255343 @default.
- W2901101732 cites W2067463198 @default.
- W2901101732 cites W2075035271 @default.
- W2901101732 cites W2083386249 @default.
- W2901101732 cites W2109070574 @default.
- W2901101732 cites W2114242405 @default.
- W2901101732 cites W2130542877 @default.
- W2901101732 cites W2131419242 @default.
- W2901101732 cites W2139723538 @default.
- W2901101732 cites W2140655321 @default.
- W2901101732 cites W2140748044 @default.
- W2901101732 cites W2147627101 @default.
- W2901101732 cites W2189790494 @default.
- W2901101732 cites W2233632661 @default.
- W2901101732 cites W2257214644 @default.
- W2901101732 cites W2264009694 @default.
- W2901101732 cites W2267567635 @default.
- W2901101732 cites W2270298109 @default.
- W2901101732 cites W2296739687 @default.
- W2901101732 cites W2303118595 @default.
- W2901101732 cites W2425862687 @default.
- W2901101732 cites W2541779393 @default.
- W2901101732 cites W2608333216 @default.
- W2901101732 cites W2620092475 @default.
- W2901101732 cites W2763971076 @default.
- W2901101732 cites W2787813347 @default.
- W2901101732 cites W4234698757 @default.
- W2901101732 cites W4236514815 @default.
- W2901101732 cites W4254998496 @default.
- W2901101732 doi "https://doi.org/10.3389/fgene.2018.00556" @default.
- W2901101732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6265307" @default.
- W2901101732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30532765" @default.
- W2901101732 hasPublicationYear "2018" @default.
- W2901101732 type Work @default.
- W2901101732 sameAs 2901101732 @default.
- W2901101732 citedByCount "43" @default.
- W2901101732 countsByYear W29011017322019 @default.
- W2901101732 countsByYear W29011017322020 @default.
- W2901101732 countsByYear W29011017322021 @default.
- W2901101732 countsByYear W29011017322022 @default.
- W2901101732 countsByYear W29011017322023 @default.
- W2901101732 crossrefType "journal-article" @default.
- W2901101732 hasAuthorship W2901101732A5003989193 @default.
- W2901101732 hasAuthorship W2901101732A5014656305 @default.
- W2901101732 hasAuthorship W2901101732A5028696869 @default.
- W2901101732 hasAuthorship W2901101732A5037320344 @default.
- W2901101732 hasAuthorship W2901101732A5044548791 @default.
- W2901101732 hasAuthorship W2901101732A5048721439 @default.
- W2901101732 hasAuthorship W2901101732A5051511582 @default.
- W2901101732 hasAuthorship W2901101732A5064285851 @default.
- W2901101732 hasAuthorship W2901101732A5074458217 @default.
- W2901101732 hasAuthorship W2901101732A5077230882 @default.
- W2901101732 hasAuthorship W2901101732A5085567767 @default.
- W2901101732 hasBestOaLocation W29011017321 @default.
- W2901101732 hasConcept C126322002 @default.