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• W2901101775 abstract "Antibiotic fermentative residues are categorized into hazardous wastes in China due to the existence of antibiotic resistance genes (ARGs) and residual antibiotics How to treat and manage these wastes is a new challenge. This paper investigated the treatment of erythromycin thiocyanate fermentation (EryTcF) residues using ionizing radiation technology for removing ARGs and antibiotics from the fermentation residues. The results showed that as exposed the EryTcF residues to gamma radiation, the abundance of four macrolide resistance genes (ereA, ermB, mefA and mpfB) decreased 1.0–1.3 log with 90–95% removal, and around 56% of erythromycin was removed at absorbed dose of 30&#x202F;kGy and room temperature (19–22&#x202F;°C). Direct action of γ-ray radiation contributed to 42–53% of ARGs removal and indirect action (radicals' reaction) was mainly responsible for erythromycin removal (84%). The positive correlation between total ARGs and Shannon index was observed. The potential ARGs-linked hosts were assigned to genera Aeromonas and Enterobacteriaceae and their abundance decreased by 36–43% at 30&#x202F;kGy. Radiation has not obvious influence on the nutrient components of residues, such as protein content, suggesting that the radiation treated fermentative residues can be used as fertilizer, which is favorable for the development of recycling economy in antibiotic pharmaceutical factory. The results could provide a new insight into a sustainable management of antibiotic fermentative residuals." @default.
• W2901101775 created "2018-11-29" @default.
• W2901101775 creator A5022750420 @default.
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• W2901101775 date "2019-02-01" @default.
• W2901101775 modified "2023-10-16" @default.
• W2901101775 title "Degradation of antibiotics and antibiotic resistance genes in fermentation residues by ionizing radiation: A new insight into a sustainable management of antibiotic fermentative residuals" @default.
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• W2901101775 doi "https://doi.org/10.1016/j.jenvman.2018.11.050" @default.
• W2901101775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30472560" @default.
• W2901101775 hasPublicationYear "2019" @default.
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