FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W29011192> ?p ?o ?g. }

• W29011192 endingPage "78" @default.
• W29011192 startingPage "469" @default.
• W29011192 abstract "The objective of this investigation was to assess the effects of chronic nicotine administration on bone status and serum calcium and calciotropic hormone levels in aged, estrogen-replete (intact, sham-operated) and estrogen-deplete (ovariectomized) female rats. Eight-month-old sham-operated (sham) and ovariectomized (ovx) retired breeder rats were maintained untreated for 3 months to allow for the development of osteopenia in the ovx group. The animals were then administered either saline, low dose nicotine (6.0 mg/kg/day), or high dose nicotine (9.0 mg/kg/day) via osmotic minipumps for 3 months. Blood was drawn at necropsy for determination of serum nicotine, cotinine, Ca, PTH, 25(OH)D, and 1,25(OH)(2)D. Right tibiae were collected and processed undecalcified for cancellous and cortical bone histomorphometry. Histomorphometric endpoints evaluated at the proximal tibial metaphysis included cancellous bone volume (BV/TV), osteoclast surface (Oc.S), osteoid surface (OS), mineralizing surface (MS), mineral apposition rate (MAR), and bone formation rate (BFR). Histomorphometric endpoints evaluated at the tibial diaphysis included cortical area (Ct.Ar), marrow area (Ma.Ar), and periosteal and endocortical MS, MAR, and BFR. Ovariectomy resulted in lower cancellous BV/TV and Ct.Ar and higher cancellous, endocortical, and periosteal MS and BFR. The presence of nicotine in serum confirmed successful delivery of the drug via osmotic minipumps. Administration of nicotine at the high dose resulted in lower serum 25(OH)D levels but differences in serum Ca or PTH were not detected with either nicotine treatment. Differences with nicotine treatment were also not detected for Oc.S at the proximal tibia. While treatment with nicotine at the high dose resulted in higher MS and BFR, in both sham and ovx rats, there were no differences due to nicotine treatment in cancellous BV/TV. Marrow area was greater in rats treated with nicotine than in rats treated with vehicle. However, differences with nicotine treatment were not detected in Ct.Ar in either intact or ovx rats. Overall, these findings indicate that steady state nicotine exposure does not alter bone mass in intact or ovx rats but may have detrimental effects on body storage of vitamin D." @default.
• W29011192 created "2016-06-24" @default.
• W29011192 creator A5005880193 @default.
• W29011192 creator A5008571716 @default.
• W29011192 creator A5030639482 @default.
• W29011192 creator A5036453193 @default.
• W29011192 creator A5038972988 @default.
• W29011192 creator A5055126462 @default.
• W29011192 date "2002-09-01" @default.
• W29011192 modified "2023-09-23" @default.
• W29011192 title "Effects of nicotine on bone and calciotropic hormones in aged ovariectomized rats." @default.
• W29011192 cites W117826162 @default.
• W29011192 cites W11987629 @default.
• W29011192 cites W1225575464 @default.
• W29011192 cites W1520516540 @default.
• W29011192 cites W1585377912 @default.
• W29011192 cites W1936476494 @default.
• W29011192 cites W1967124686 @default.
• W29011192 cites W1967492863 @default.
• W29011192 cites W1972812519 @default.
• W29011192 cites W1974087769 @default.
• W29011192 cites W1974444557 @default.
• W29011192 cites W1979851608 @default.
• W29011192 cites W1996007424 @default.
• W29011192 cites W2014172138 @default.
• W29011192 cites W2014333033 @default.
• W29011192 cites W2017521193 @default.
• W29011192 cites W2017574768 @default.
• W29011192 cites W2018022212 @default.
• W29011192 cites W2021076013 @default.
• W29011192 cites W2023531995 @default.
• W29011192 cites W2024403468 @default.
• W29011192 cites W2027093084 @default.
• W29011192 cites W2031258101 @default.
• W29011192 cites W2036659284 @default.
• W29011192 cites W2037186387 @default.
• W29011192 cites W2040645421 @default.
• W29011192 cites W2042943196 @default.
• W29011192 cites W2047318213 @default.
• W29011192 cites W2058104740 @default.
• W29011192 cites W2067950265 @default.
• W29011192 cites W2077817309 @default.
• W29011192 cites W2079121449 @default.
• W29011192 cites W2081278178 @default.
• W29011192 cites W2081314614 @default.
• W29011192 cites W2086416155 @default.
• W29011192 cites W2138384796 @default.
• W29011192 cites W2186715574 @default.
• W29011192 cites W2417578419 @default.
• W29011192 cites W3203441888 @default.
• W29011192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15758416" @default.
• W29011192 hasPublicationYear "2002" @default.
• W29011192 type Work @default.
• W29011192 sameAs 29011192 @default.
• W29011192 citedByCount "3" @default.
• W29011192 countsByYear W290111922014 @default.
• W29011192 countsByYear W290111922020 @default.
• W29011192 crossrefType "journal-article" @default.
• W29011192 hasAuthorship W29011192A5005880193 @default.
• W29011192 hasAuthorship W29011192A5008571716 @default.
• W29011192 hasAuthorship W29011192A5030639482 @default.
• W29011192 hasAuthorship W29011192A5036453193 @default.
• W29011192 hasAuthorship W29011192A5038972988 @default.
• W29011192 hasAuthorship W29011192A5055126462 @default.
• W29011192 hasConcept C105702510 @default.
• W29011192 hasConcept C126322002 @default.
• W29011192 hasConcept C134018914 @default.
• W29011192 hasConcept C170033053 @default.
• W29011192 hasConcept C170493617 @default.
• W29011192 hasConcept C185592680 @default.
• W29011192 hasConcept C2776033226 @default.
• W29011192 hasConcept C2776350087 @default.
• W29011192 hasConcept C2776541429 @default.
• W29011192 hasConcept C2776886416 @default.
• W29011192 hasConcept C2777083390 @default.
• W29011192 hasConcept C2777164284 @default.
• W29011192 hasConcept C2779547902 @default.
• W29011192 hasConcept C2781208988 @default.
• W29011192 hasConcept C2781451080 @default.
• W29011192 hasConcept C519063684 @default.
• W29011192 hasConcept C673006 @default.
• W29011192 hasConcept C71924100 @default.
• W29011192 hasConcept C81880429 @default.
• W29011192 hasConcept C8264082 @default.
• W29011192 hasConceptScore W29011192C105702510 @default.
• W29011192 hasConceptScore W29011192C126322002 @default.
• W29011192 hasConceptScore W29011192C134018914 @default.
• W29011192 hasConceptScore W29011192C170033053 @default.
• W29011192 hasConceptScore W29011192C170493617 @default.
• W29011192 hasConceptScore W29011192C185592680 @default.
• W29011192 hasConceptScore W29011192C2776033226 @default.
• W29011192 hasConceptScore W29011192C2776350087 @default.
• W29011192 hasConceptScore W29011192C2776541429 @default.
• W29011192 hasConceptScore W29011192C2776886416 @default.
• W29011192 hasConceptScore W29011192C2777083390 @default.
• W29011192 hasConceptScore W29011192C2777164284 @default.
• W29011192 hasConceptScore W29011192C2779547902 @default.
• W29011192 hasConceptScore W29011192C2781208988 @default.

• next