Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901150549> ?p ?o ?g. }
- W2901150549 endingPage "281" @default.
- W2901150549 startingPage "268" @default.
- W2901150549 abstract "Background: X-linked hypophosphatemia (XLH) is the most common form of familial phosphate-wasting disorders, due to an inactivating mutation in the phosphate-regulating neutral endopeptidase, X-linked gene. Persistent osteomalacia, enthesophytes, osteophytes, degenerative arthritis and dental abscesses/periodontal disease dominate the adult disorder. However, the impact of insufficient phosphate on hydroxyapatite composition, the major inorganic component of bone and teeth, is unknown in individuals with XLH. Methods: Using Raman spectroscopy, the carbonate (CO 3 2− ) to phosphate (PO 4 3− ) ion ratio was measured in HYP and wild-type mice and in primary and permanent teeth from XLH individuals and unaffected controls. Results: There was a significant difference in carbonate ion substitution between the HYP and wild-type femoral cortical bone (0.36 ± 0.08 versus 0.24 ± 0.04; p < 0.001). Carbonate ion substitution levels were also higher in permanent XLH teeth compared with unaffected individuals (0.39 ± 0.12 versus 0.23 ± 0.04; p < 0.001), but not in primary teeth (0.29 ± 0.11 versus 0.26 ± 0.02; p = 0.29). Complementary Fourier transform infrared analyses demonstrated higher relative intensities of the four major vibrational bands originating from the carbonate anion in XLH teeth compared with unaffected controls. Conclusion: Ionic substitution within the crystal lattice is a common feature of hydroxyapatite and one that confers the physiological properties of bone that impact mechanical strength and the process of bone remodeling. Our data demonstrating anionic substitution in human dentin from individuals with XLH validate the use of dentin as a proxy for bone and to better understand the molecular adaptations that occur in the biochemical milieu of XLH." @default.
- W2901150549 created "2018-11-29" @default.
- W2901150549 creator A5030624061 @default.
- W2901150549 creator A5043168638 @default.
- W2901150549 creator A5047769327 @default.
- W2901150549 creator A5054539399 @default.
- W2901150549 creator A5058672408 @default.
- W2901150549 creator A5080789213 @default.
- W2901150549 date "2018-10-11" @default.
- W2901150549 modified "2023-09-27" @default.
- W2901150549 title "Vibrational spectroscopic analysis of hydroxyapatite in HYP mice and individuals with X-linked hypophosphatemia" @default.
- W2901150549 cites W146440784 @default.
- W2901150549 cites W1527208521 @default.
- W2901150549 cites W1611786178 @default.
- W2901150549 cites W181616004 @default.
- W2901150549 cites W1969373023 @default.
- W2901150549 cites W1972442964 @default.
- W2901150549 cites W1973544468 @default.
- W2901150549 cites W197840620 @default.
- W2901150549 cites W1978523374 @default.
- W2901150549 cites W1979039743 @default.
- W2901150549 cites W1985742682 @default.
- W2901150549 cites W1996555833 @default.
- W2901150549 cites W2005601953 @default.
- W2901150549 cites W2005991632 @default.
- W2901150549 cites W2006629115 @default.
- W2901150549 cites W2017452957 @default.
- W2901150549 cites W2023186025 @default.
- W2901150549 cites W2023739541 @default.
- W2901150549 cites W2024475114 @default.
- W2901150549 cites W2032659134 @default.
- W2901150549 cites W2032806614 @default.
- W2901150549 cites W2032995692 @default.
- W2901150549 cites W2040747383 @default.
- W2901150549 cites W2042062769 @default.
- W2901150549 cites W2044997452 @default.
- W2901150549 cites W2045129957 @default.
- W2901150549 cites W2050698413 @default.
- W2901150549 cites W2055274621 @default.
- W2901150549 cites W2058871893 @default.
- W2901150549 cites W2059783585 @default.
- W2901150549 cites W2060441505 @default.
- W2901150549 cites W2061807047 @default.
- W2901150549 cites W2061971435 @default.
- W2901150549 cites W2062638851 @default.
- W2901150549 cites W2062979535 @default.
- W2901150549 cites W2065644879 @default.
- W2901150549 cites W2070609286 @default.
- W2901150549 cites W2074342958 @default.
- W2901150549 cites W2078771160 @default.
- W2901150549 cites W2081314614 @default.
- W2901150549 cites W2087993906 @default.
- W2901150549 cites W2088359126 @default.
- W2901150549 cites W2089248086 @default.
- W2901150549 cites W2122613318 @default.
- W2901150549 cites W2125090114 @default.
- W2901150549 cites W2130611413 @default.
- W2901150549 cites W2137140584 @default.
- W2901150549 cites W2139458978 @default.
- W2901150549 cites W2140330355 @default.
- W2901150549 cites W2143616070 @default.
- W2901150549 cites W2145211422 @default.
- W2901150549 cites W2158902638 @default.
- W2901150549 cites W2163402984 @default.
- W2901150549 cites W2169887586 @default.
- W2901150549 cites W2226989374 @default.
- W2901150549 cites W2251239626 @default.
- W2901150549 cites W2259847155 @default.
- W2901150549 cites W2404736292 @default.
- W2901150549 cites W2409592419 @default.
- W2901150549 cites W2502193446 @default.
- W2901150549 cites W2527550773 @default.
- W2901150549 cites W27253850 @default.
- W2901150549 cites W2752181067 @default.
- W2901150549 cites W4292689881 @default.
- W2901150549 cites W2149893466 @default.
- W2901150549 cites W2559891376 @default.
- W2901150549 doi "https://doi.org/10.1177/2040622318804753" @default.
- W2901150549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6348532" @default.
- W2901150549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30719271" @default.
- W2901150549 hasPublicationYear "2018" @default.
- W2901150549 type Work @default.
- W2901150549 sameAs 2901150549 @default.
- W2901150549 citedByCount "12" @default.
- W2901150549 countsByYear W29011505492019 @default.
- W2901150549 countsByYear W29011505492020 @default.
- W2901150549 countsByYear W29011505492021 @default.
- W2901150549 countsByYear W29011505492022 @default.
- W2901150549 countsByYear W29011505492023 @default.
- W2901150549 crossrefType "journal-article" @default.
- W2901150549 hasAuthorship W2901150549A5030624061 @default.
- W2901150549 hasAuthorship W2901150549A5043168638 @default.
- W2901150549 hasAuthorship W2901150549A5047769327 @default.
- W2901150549 hasAuthorship W2901150549A5054539399 @default.
- W2901150549 hasAuthorship W2901150549A5058672408 @default.
- W2901150549 hasAuthorship W2901150549A5080789213 @default.
- W2901150549 hasBestOaLocation W29011505491 @default.
- W2901150549 hasConcept C120665830 @default.