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• W2901162364 abstract "Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Acute exacerbations of COPD (AECOPD) are major driver for healthcare utilization with each exacerbation begetting the next exacerbation. It is, therefore, important to treat each episode effectively to prevent the next. However, this can be challenging as AECOPD result from complex interactions between host, environment and infective agents. The benefits of starting antibiotics in AECOPD, which are not life-threatening (e.g. not requiring mechanical ventilation) or not complicated by pneumonia remain controversial.The use of procalcitonin to guide antibiotic therapy in AECOPD has gained interest in recent years. The main advantage of this approach is a safe reduction in antibiotic use in a large group of patients, which may potentially translate to several other benefits. These include reduced antibiotic-related side-effects, reduced risk of developing antibiotic-resistant organisms and cost savings. This approach is associated with no increase in mortality or morbidity such as treatment failure, re-admission, admission to ICU.Procalcitonin-guided antibiotic therapy in AECOPD is a promising and safe approach, which may be ready for the prime time." @default.
• W2901162364 created "2018-11-29" @default.
• W2901162364 creator A5017458408 @default.
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• W2901162364 date "2019-03-01" @default.
• W2901162364 modified "2023-09-23" @default.
• W2901162364 title "Procalcitonin and antibiotics in moderate–severe acute exacerbation of chronic obstructive pulmonary disease" @default.
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• W2901162364 doi "https://doi.org/10.1097/mcp.0000000000000548" @default.
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