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- W2901162523 abstract "Quantitative studies of the short-term feedback of testosterone (T) on luteinizing hormone (LH) secretion in healthy men are relatively rare. Such studies require the shutting down of endogenous T secretion and the imposition of experimentally controlled IV T addback. To evaluate whether pulsatile and continuous T delivery confers equivalent negative feedback on LH secretion. This was a placebo-controlled, blinded, and prospectively randomized crossover study comprising 16 healthy men [age range 23 to 54 years and a body mass index (BMI) between 22.3 and 34.2 kg/m2]. Subjects received ketoconazole to block endogenous T secretion and received continuous or 90-minute pulses of IV T addback. The study was performed in a Clinical Translational Research Unit. Subjects underwent 14 hours of blood sampling at 10-minute intervals, with a bolus IV injection of 33 ng/kg gonadotropin-releasing hormone (GnRH). Log-transformed LH and T concentration ratios before and after GnRH administration. Despite higher T concentrations during pulsatile T feedback, LH concentrations and secretion rates, whether driven by endogenous or exogenous GnRH, were similar to those during continuous T infusion, indicating diminished pulsatile T feedback. Feedback correlated negatively with BMI. Under controlled T feedback, basal but not pulsatile LH secretion correlated negatively with CT-estimated visceral fat mass. Feedback by pulsatile T delivery has diminished inhibitory strength compared with continuous infusion. Feedback is negatively correlated with BMI." @default.
- W2901162523 created "2018-11-29" @default.
- W2901162523 creator A5003698342 @default.
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- W2901162523 creator A5050153467 @default.
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- W2901162523 date "2018-11-23" @default.
- W2901162523 modified "2023-10-18" @default.
- W2901162523 title "Feedback on LH in Testosterone-Clamped Men Depends on the Mode of Testosterone Administration and Body Composition" @default.
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- W2901162523 doi "https://doi.org/10.1210/js.2018-00317" @default.
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