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- W2901165736 abstract "Using high resolution optical and electron microscopy, we show that centrally accumulated T cell receptors (TCR) at in the center of the immunological synapse (IS) is located on the surface of extracellular microvesicles that bud at the IS center. An early endosomal-sorting complex required for transport (ESCRT) sorts TCR for inclusion in microvesicles, while terminal ESCRT components mediate scission of microvesicles from the T cell plasma membrane. The HIV polyprotein GAG co-opts this process for budding of virus-like particles. B cells bearing cognate pMHC receive TCR from T cells and initiate intracellular signals in response to isolated synaptic microvesicles. These microvesicles deliver transcellular signals across antigen-dependent synapses by engaging cognate pMHC on APC." @default.
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- W2901165736 date "2013-04-01" @default.
- W2901165736 modified "2023-10-15" @default.
- W2901165736 title "Polarized release of TCR‐enriched microvesicles at the center of the T cell immunological synapse" @default.
- W2901165736 doi "https://doi.org/10.1096/fasebj.27.1_supplement.553.24" @default.
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