Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901168719> ?p ?o ?g. }
- W2901168719 endingPage "e1007782" @default.
- W2901168719 startingPage "e1007782" @default.
- W2901168719 abstract "Telomere-binding proteins constituting the shelterin complex have been studied primarily for telomeric functions. However, mounting evidence shows non-telomeric binding and gene regulation by shelterin factors. This raises a key question-do telomeres impact binding of shelterin proteins at distal non-telomeric sites? Here we show that binding of the telomere-repeat-binding-factor-2 (TRF2) at promoters ~60 Mb from telomeres depends on telomere length in human cells. Promoter TRF2 occupancy was depleted in cells with elongated telomeres resulting in altered TRF2-mediated transcription of distal genes. In addition, histone modifications-activation (H3K4me1 and H3K4me3) as well as silencing marks (H3K27me3)-at distal promoters were telomere length-dependent. These demonstrate that transcription, and the epigenetic state, of telomere-distal promoters can be influenced by telomere length. Molecular links between telomeres and the extra-telomeric genome, emerging from findings here, might have important implications in telomere-related physiology, particularly ageing and cancer." @default.
- W2901168719 created "2018-11-29" @default.
- W2901168719 creator A5008369067 @default.
- W2901168719 creator A5045143118 @default.
- W2901168719 creator A5047550576 @default.
- W2901168719 creator A5064497507 @default.
- W2901168719 creator A5075717770 @default.
- W2901168719 creator A5081012778 @default.
- W2901168719 creator A5086098906 @default.
- W2901168719 creator A5087306262 @default.
- W2901168719 creator A5088442620 @default.
- W2901168719 creator A5090689566 @default.
- W2901168719 date "2018-11-15" @default.
- W2901168719 modified "2023-10-12" @default.
- W2901168719 title "Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends" @default.
- W2901168719 cites W1488008687 @default.
- W2901168719 cites W1965019589 @default.
- W2901168719 cites W1972163403 @default.
- W2901168719 cites W1972171756 @default.
- W2901168719 cites W1974732946 @default.
- W2901168719 cites W1978727038 @default.
- W2901168719 cites W1991124252 @default.
- W2901168719 cites W1996800742 @default.
- W2901168719 cites W2002170582 @default.
- W2901168719 cites W2010842801 @default.
- W2901168719 cites W2018182154 @default.
- W2901168719 cites W2023643761 @default.
- W2901168719 cites W2032694449 @default.
- W2901168719 cites W2033731825 @default.
- W2901168719 cites W2035244223 @default.
- W2901168719 cites W2044493529 @default.
- W2901168719 cites W2047832668 @default.
- W2901168719 cites W2048921738 @default.
- W2901168719 cites W2049947939 @default.
- W2901168719 cites W2056352736 @default.
- W2901168719 cites W2058346978 @default.
- W2901168719 cites W2060311056 @default.
- W2901168719 cites W2062395030 @default.
- W2901168719 cites W2068394064 @default.
- W2901168719 cites W2072744580 @default.
- W2901168719 cites W2075202222 @default.
- W2901168719 cites W2081237863 @default.
- W2901168719 cites W2081378898 @default.
- W2901168719 cites W2084575716 @default.
- W2901168719 cites W2087017789 @default.
- W2901168719 cites W2087831639 @default.
- W2901168719 cites W2090388015 @default.
- W2901168719 cites W2092967525 @default.
- W2901168719 cites W2102743836 @default.
- W2901168719 cites W2102839588 @default.
- W2901168719 cites W2116282320 @default.
- W2901168719 cites W2119762097 @default.
- W2901168719 cites W2122103654 @default.
- W2901168719 cites W2123105653 @default.
- W2901168719 cites W2125663907 @default.
- W2901168719 cites W2126815966 @default.
- W2901168719 cites W2130272241 @default.
- W2901168719 cites W2134635469 @default.
- W2901168719 cites W2134957097 @default.
- W2901168719 cites W2136350201 @default.
- W2901168719 cites W2140944222 @default.
- W2901168719 cites W2142325519 @default.
- W2901168719 cites W2156826645 @default.
- W2901168719 cites W2157009395 @default.
- W2901168719 cites W2157832000 @default.
- W2901168719 cites W2160185049 @default.
- W2901168719 cites W2162262059 @default.
- W2901168719 cites W2175722093 @default.
- W2901168719 cites W2334974904 @default.
- W2901168719 cites W2342847104 @default.
- W2901168719 cites W2562574576 @default.
- W2901168719 cites W2755331108 @default.
- W2901168719 cites W2765080185 @default.
- W2901168719 cites W2802948734 @default.
- W2901168719 cites W3187872748 @default.
- W2901168719 cites W36853749 @default.
- W2901168719 doi "https://doi.org/10.1371/journal.pgen.1007782" @default.
- W2901168719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7580915" @default.
- W2901168719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33091002" @default.
- W2901168719 hasPublicationYear "2018" @default.
- W2901168719 type Work @default.
- W2901168719 sameAs 2901168719 @default.
- W2901168719 citedByCount "42" @default.
- W2901168719 countsByYear W29011687192019 @default.
- W2901168719 countsByYear W29011687192020 @default.
- W2901168719 countsByYear W29011687192021 @default.
- W2901168719 countsByYear W29011687192022 @default.
- W2901168719 countsByYear W29011687192023 @default.
- W2901168719 crossrefType "journal-article" @default.
- W2901168719 hasAuthorship W2901168719A5008369067 @default.
- W2901168719 hasAuthorship W2901168719A5045143118 @default.
- W2901168719 hasAuthorship W2901168719A5047550576 @default.
- W2901168719 hasAuthorship W2901168719A5064497507 @default.
- W2901168719 hasAuthorship W2901168719A5075717770 @default.
- W2901168719 hasAuthorship W2901168719A5081012778 @default.
- W2901168719 hasAuthorship W2901168719A5086098906 @default.
- W2901168719 hasAuthorship W2901168719A5087306262 @default.
- W2901168719 hasAuthorship W2901168719A5088442620 @default.