Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901169867> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2901169867 abstract "Toll-like receptors (TLRs) are critical receptors for pathogen detection following microbial infections. In addition, they participate in responding to a variety of tissue damage-derived endogenous molecules. In both processes, binding of a ligand induces the dimerization of two TLRs and stimulates cellular immune responses. Occasionally, however, the activation of TLRs can also result in chronic inflammation diseases. This happens in situations where control over the release of pro-inflammatory cytokines is lost. Possible treatments include the usage of antagonistic drugs that inhibit the TLR-based immune response.The monoclonal antibody OPN-305, an efficient inhibitor of TLR2, has successfully been used to treat septic shock and rheumatoid arthritis in mice and ischemia/reperfusion injury in humans. However, whereas the efficacy of the antibody was well established, its molecular mechanism remained unexplained.In this thesis, the complex between the extracellular domain of murine TLR2 and the fragment antigen-binding domain of OPN-305 was generated and purified. A first structural description of this complex was achieved by negative stain electron microscopy (EM) at a resolution of ~22 A. The three-dimensional reconstruction reveals that the antibody binds laterally within the TLR1/TLR6 dimerization interface. The results indicate that the leucine rich repeats 11 to 14 are involved in the protein-protein interaction allowing ten amino acids on the surface of TLR2 to be identified as constituting the probable, highly discontinuous epitope. These results immediately suggest the mechanism of TLR2 inhibition and the antagonistic property of OPN-305 to derive from its ability to block the heterodimerization of TLR2 resulting in silencing of downstream signaling cascades." @default.
- W2901169867 created "2018-11-29" @default.
- W2901169867 creator A5036435902 @default.
- W2901169867 date "2012-10-11" @default.
- W2901169867 modified "2023-09-27" @default.
- W2901169867 title "Structural analysis of the specific inactivation of Toll-like receptor 2" @default.
- W2901169867 hasPublicationYear "2012" @default.
- W2901169867 type Work @default.
- W2901169867 sameAs 2901169867 @default.
- W2901169867 citedByCount "0" @default.
- W2901169867 crossrefType "dissertation" @default.
- W2901169867 hasAuthorship W2901169867A5036435902 @default.
- W2901169867 hasConcept C136449434 @default.
- W2901169867 hasConcept C159654299 @default.
- W2901169867 hasConcept C170493617 @default.
- W2901169867 hasConcept C185592680 @default.
- W2901169867 hasConcept C195616568 @default.
- W2901169867 hasConcept C203014093 @default.
- W2901169867 hasConcept C2776709828 @default.
- W2901169867 hasConcept C2776914184 @default.
- W2901169867 hasConcept C2781236682 @default.
- W2901169867 hasConcept C542903549 @default.
- W2901169867 hasConcept C55493867 @default.
- W2901169867 hasConcept C86803240 @default.
- W2901169867 hasConcept C8891405 @default.
- W2901169867 hasConcept C95444343 @default.
- W2901169867 hasConceptScore W2901169867C136449434 @default.
- W2901169867 hasConceptScore W2901169867C159654299 @default.
- W2901169867 hasConceptScore W2901169867C170493617 @default.
- W2901169867 hasConceptScore W2901169867C185592680 @default.
- W2901169867 hasConceptScore W2901169867C195616568 @default.
- W2901169867 hasConceptScore W2901169867C203014093 @default.
- W2901169867 hasConceptScore W2901169867C2776709828 @default.
- W2901169867 hasConceptScore W2901169867C2776914184 @default.
- W2901169867 hasConceptScore W2901169867C2781236682 @default.
- W2901169867 hasConceptScore W2901169867C542903549 @default.
- W2901169867 hasConceptScore W2901169867C55493867 @default.
- W2901169867 hasConceptScore W2901169867C86803240 @default.
- W2901169867 hasConceptScore W2901169867C8891405 @default.
- W2901169867 hasConceptScore W2901169867C95444343 @default.
- W2901169867 hasLocation W29011698671 @default.
- W2901169867 hasOpenAccess W2901169867 @default.
- W2901169867 hasPrimaryLocation W29011698671 @default.
- W2901169867 hasRelatedWork W1541214776 @default.
- W2901169867 hasRelatedWork W157358940 @default.
- W2901169867 hasRelatedWork W1896307869 @default.
- W2901169867 hasRelatedWork W1902844247 @default.
- W2901169867 hasRelatedWork W1969840353 @default.
- W2901169867 hasRelatedWork W1972283449 @default.
- W2901169867 hasRelatedWork W1979625030 @default.
- W2901169867 hasRelatedWork W1988200410 @default.
- W2901169867 hasRelatedWork W2065276143 @default.
- W2901169867 hasRelatedWork W2096586021 @default.
- W2901169867 hasRelatedWork W2112275532 @default.
- W2901169867 hasRelatedWork W2115423440 @default.
- W2901169867 hasRelatedWork W2117365118 @default.
- W2901169867 hasRelatedWork W2152702111 @default.
- W2901169867 hasRelatedWork W2733374716 @default.
- W2901169867 hasRelatedWork W2808241657 @default.
- W2901169867 hasRelatedWork W2865105735 @default.
- W2901169867 hasRelatedWork W2992945338 @default.
- W2901169867 hasRelatedWork W3206768333 @default.
- W2901169867 hasRelatedWork W1541252732 @default.
- W2901169867 isParatext "false" @default.
- W2901169867 isRetracted "false" @default.
- W2901169867 magId "2901169867" @default.
- W2901169867 workType "dissertation" @default.