Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901202355> ?p ?o ?g. }
- W2901202355 abstract "The mechanisms of J wave syndrome (JWS) are incompletely understood. Here, we showed that the concomitant activation of small-conductance calcium-activated potassium (SK) current (IKAS) and inhibition of sodium current by cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA) recapitulate the phenotypes of JWS in Langendorff-perfused rabbit hearts. CyPPA induced significant J wave elevation and frequent spontaneous ventricular fibrillation (SVF), as well as sinus bradycardia, atrioventricular block, and intraventricular conduction delay. IKAS activation by CyPPA resulted in heterogeneous shortening of action potential (AP) duration (APD) and repolarization alternans. CyPPA inhibited cardiac sodium current (INa) and decelerated AP upstroke and intracellular calcium transient. SVFs were typically triggered by short-coupled premature ventricular contractions, initiated with phase 2 reentry and originated more frequently from the right than the left ventricles. Subsequent IKAS blockade by apamin reduced J wave elevation and eliminated SVF. β-Adrenergic stimulation was antiarrhythmic in CyPPA-induced electrical storm. Like CyPPA, hypothermia (32.0°C) also induced J wave elevation and SVF. It facilitated negative calcium-voltage coupling and phase 2 repolarization alternans with spatial and electromechanical discordance, which were ameliorated by apamin. These findings suggest that IKAS activation contributes to the development of JWS in rabbit ventricles." @default.
- W2901202355 created "2018-11-29" @default.
- W2901202355 creator A5004272413 @default.
- W2901202355 creator A5006823579 @default.
- W2901202355 creator A5009561014 @default.
- W2901202355 creator A5010321727 @default.
- W2901202355 creator A5010869331 @default.
- W2901202355 creator A5011548233 @default.
- W2901202355 creator A5012421606 @default.
- W2901202355 creator A5014728926 @default.
- W2901202355 creator A5048900402 @default.
- W2901202355 creator A5051699207 @default.
- W2901202355 creator A5058084490 @default.
- W2901202355 creator A5068975319 @default.
- W2901202355 creator A5091701619 @default.
- W2901202355 date "2018-11-15" @default.
- W2901202355 modified "2023-10-12" @default.
- W2901202355 title "Concomitant SK current activation and sodium current inhibition cause J wave syndrome" @default.
- W2901202355 cites W1861294888 @default.
- W2901202355 cites W1874320426 @default.
- W2901202355 cites W1968715433 @default.
- W2901202355 cites W1986076522 @default.
- W2901202355 cites W1997925229 @default.
- W2901202355 cites W2012661354 @default.
- W2901202355 cites W2026099577 @default.
- W2901202355 cites W2028300810 @default.
- W2901202355 cites W2030842103 @default.
- W2901202355 cites W2031804346 @default.
- W2901202355 cites W2040437516 @default.
- W2901202355 cites W2042998312 @default.
- W2901202355 cites W2043207949 @default.
- W2901202355 cites W2043822158 @default.
- W2901202355 cites W2046140079 @default.
- W2901202355 cites W2046336333 @default.
- W2901202355 cites W2049555075 @default.
- W2901202355 cites W2059821011 @default.
- W2901202355 cites W2061593357 @default.
- W2901202355 cites W2081096698 @default.
- W2901202355 cites W2083337612 @default.
- W2901202355 cites W2100414478 @default.
- W2901202355 cites W2107376533 @default.
- W2901202355 cites W2113916329 @default.
- W2901202355 cites W2114443373 @default.
- W2901202355 cites W2125058889 @default.
- W2901202355 cites W2130592328 @default.
- W2901202355 cites W2139661937 @default.
- W2901202355 cites W2148204431 @default.
- W2901202355 cites W2151214424 @default.
- W2901202355 cites W2152124147 @default.
- W2901202355 cites W2158867436 @default.
- W2901202355 cites W2159797629 @default.
- W2901202355 cites W2162185044 @default.
- W2901202355 cites W2410608961 @default.
- W2901202355 cites W2462849927 @default.
- W2901202355 cites W2464776507 @default.
- W2901202355 cites W2476657252 @default.
- W2901202355 cites W2544855682 @default.
- W2901202355 cites W2547382423 @default.
- W2901202355 cites W2557356194 @default.
- W2901202355 cites W2620415438 @default.
- W2901202355 cites W2754315238 @default.
- W2901202355 cites W2791318952 @default.
- W2901202355 cites W2800108839 @default.
- W2901202355 doi "https://doi.org/10.1172/jci.insight.122329" @default.
- W2901202355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6302939" @default.
- W2901202355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30429367" @default.
- W2901202355 hasPublicationYear "2018" @default.
- W2901202355 type Work @default.
- W2901202355 sameAs 2901202355 @default.
- W2901202355 citedByCount "17" @default.
- W2901202355 countsByYear W29012023552019 @default.
- W2901202355 countsByYear W29012023552020 @default.
- W2901202355 countsByYear W29012023552021 @default.
- W2901202355 countsByYear W29012023552022 @default.
- W2901202355 countsByYear W29012023552023 @default.
- W2901202355 crossrefType "journal-article" @default.
- W2901202355 hasAuthorship W2901202355A5004272413 @default.
- W2901202355 hasAuthorship W2901202355A5006823579 @default.
- W2901202355 hasAuthorship W2901202355A5009561014 @default.
- W2901202355 hasAuthorship W2901202355A5010321727 @default.
- W2901202355 hasAuthorship W2901202355A5010869331 @default.
- W2901202355 hasAuthorship W2901202355A5011548233 @default.
- W2901202355 hasAuthorship W2901202355A5012421606 @default.
- W2901202355 hasAuthorship W2901202355A5014728926 @default.
- W2901202355 hasAuthorship W2901202355A5048900402 @default.
- W2901202355 hasAuthorship W2901202355A5051699207 @default.
- W2901202355 hasAuthorship W2901202355A5058084490 @default.
- W2901202355 hasAuthorship W2901202355A5068975319 @default.
- W2901202355 hasAuthorship W2901202355A5091701619 @default.
- W2901202355 hasBestOaLocation W29012023551 @default.
- W2901202355 hasConcept C126322002 @default.
- W2901202355 hasConcept C134018914 @default.
- W2901202355 hasConcept C146403970 @default.
- W2901202355 hasConcept C155730078 @default.
- W2901202355 hasConcept C164705383 @default.
- W2901202355 hasConcept C185263204 @default.
- W2901202355 hasConcept C185592680 @default.
- W2901202355 hasConcept C2776919887 @default.
- W2901202355 hasConcept C2781005686 @default.
- W2901202355 hasConcept C519063684 @default.