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• W2901226061 endingPage "S591" @default.
• W2901226061 startingPage "S588" @default.
• W2901226061 abstract "No therapeutics are approved for the treatment of filovirus infections. Bepridil, a calcium channel blocker developed for treating angina, was identified as a potent inhibitor of filoviruses in vitro, including Ebola and Marburg viruses, and Ebola virus in vivo. We evaluated the efficacy of bepridil in a lethal mouse model of Marburg virus disease. A dose of 12 mg/kg bepridil once or twice daily resulted in 80% or 90% survival, respectively. These data confirm bepridil’s broad-spectrum anti-filovirus activity warranting further investigation of bepridil, or improved compounds with a similar mechanism, as a pan-filovirus therapeutic agent." @default.
• W2901226061 created "2018-11-29" @default.
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• W2901226061 date "2018-07-04" @default.
• W2901226061 modified "2023-10-16" @default.
• W2901226061 title "The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease" @default.
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• W2901226061 doi "https://doi.org/10.1093/infdis/jiy332" @default.
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