Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901272272> ?p ?o ?g. }
- W2901272272 abstract "Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings." @default.
- W2901272272 created "2018-11-29" @default.
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- W2901272272 date "2018-11-22" @default.
- W2901272272 modified "2023-10-18" @default.
- W2901272272 title "Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events" @default.
- W2901272272 cites W1494075612 @default.
- W2901272272 cites W1519266993 @default.
- W2901272272 cites W1537776120 @default.
- W2901272272 cites W1922786159 @default.
- W2901272272 cites W1961438741 @default.
- W2901272272 cites W1963968249 @default.
- W2901272272 cites W1968754632 @default.
- W2901272272 cites W1969576420 @default.
- W2901272272 cites W1969623419 @default.
- W2901272272 cites W1981264193 @default.
- W2901272272 cites W1995984818 @default.
- W2901272272 cites W2000300989 @default.
- W2901272272 cites W2007495877 @default.
- W2901272272 cites W2013814485 @default.
- W2901272272 cites W2020931572 @default.
- W2901272272 cites W2023130009 @default.
- W2901272272 cites W2023343746 @default.
- W2901272272 cites W2026345779 @default.
- W2901272272 cites W2028302194 @default.
- W2901272272 cites W2030322110 @default.
- W2901272272 cites W2031872206 @default.
- W2901272272 cites W2033078860 @default.
- W2901272272 cites W2033380504 @default.
- W2901272272 cites W2036909529 @default.
- W2901272272 cites W2037852973 @default.
- W2901272272 cites W2041612616 @default.
- W2901272272 cites W2051697670 @default.
- W2901272272 cites W2054683291 @default.
- W2901272272 cites W2055043387 @default.
- W2901272272 cites W2057472243 @default.
- W2901272272 cites W2066554965 @default.
- W2901272272 cites W2067558229 @default.
- W2901272272 cites W2067829962 @default.
- W2901272272 cites W2070443686 @default.
- W2901272272 cites W2073523429 @default.
- W2901272272 cites W2075925574 @default.
- W2901272272 cites W2076635391 @default.
- W2901272272 cites W2087530679 @default.
- W2901272272 cites W2089094370 @default.
- W2901272272 cites W2089903528 @default.
- W2901272272 cites W2097854476 @default.
- W2901272272 cites W2100584182 @default.
- W2901272272 cites W2102806269 @default.
- W2901272272 cites W2103989310 @default.
- W2901272272 cites W2106042714 @default.
- W2901272272 cites W2111647009 @default.
- W2901272272 cites W2112814626 @default.
- W2901272272 cites W2120772351 @default.
- W2901272272 cites W2123131158 @default.
- W2901272272 cites W2126579241 @default.
- W2901272272 cites W2127848554 @default.
- W2901272272 cites W2128832587 @default.
- W2901272272 cites W2131101891 @default.
- W2901272272 cites W2131871062 @default.
- W2901272272 cites W2135992665 @default.
- W2901272272 cites W2139134537 @default.
- W2901272272 cites W2148698435 @default.
- W2901272272 cites W2149525061 @default.
- W2901272272 cites W2152207030 @default.
- W2901272272 cites W2154403718 @default.
- W2901272272 cites W2164026798 @default.
- W2901272272 cites W2168649705 @default.
- W2901272272 cites W2171336109 @default.
- W2901272272 cites W2187842183 @default.
- W2901272272 cites W2198960593 @default.
- W2901272272 cites W2228472267 @default.
- W2901272272 cites W2271593394 @default.
- W2901272272 cites W2551648304 @default.
- W2901272272 cites W2555740758 @default.
- W2901272272 cites W2578150364 @default.
- W2901272272 cites W2604308930 @default.
- W2901272272 cites W2605168226 @default.
- W2901272272 cites W2609207099 @default.
- W2901272272 cites W2763567166 @default.
- W2901272272 cites W2951464304 @default.
- W2901272272 cites W4210979710 @default.
- W2901272272 cites W4297832928 @default.
- W2901272272 doi "https://doi.org/10.7554/elife.35774" @default.
- W2901272272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6307864" @default.
- W2901272272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30465522" @default.
- W2901272272 hasPublicationYear "2018" @default.