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- W2901287462 abstract "A phenanthroline (phen) tethered berberine dimer 1 is synthesized and further conjugated with carboxyfluorescein (FAM)-labeled single-stranded probe DNA (P-DNA) to give P-DNA@1. The mutual interaction of these two components triggers the fluorescence quenching of FAM, and the non-emissive P-DNA@1, in turn, functions as a sensor to detect cancer-associated microRNA-185 (miRNA-185), characterized by the FAM fluorescence recovery. The results show that P-DNA@1 is capable of detecting miRNA-185 in 2 min with the detection limit of 0.2 nM. The detection mechanism was supported by fluorescence anisotropy, binding constant and molecular docking study. Competing experiments further indicate that P-DNA@1 exhibits a high selectivity for miRNA-185 thus has a good potential in the diagnosis of related cancer at the early stage." @default.
- W2901287462 created "2018-11-29" @default.
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- W2901287462 date "2019-03-01" @default.
- W2901287462 modified "2023-09-23" @default.
- W2901287462 title "Phenanthroline-linked berberine dimer and fluorophore-tagged DNA conjugate for the selective detection of microRNA-185: Experimental and molecular docking studies" @default.
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- W2901287462 doi "https://doi.org/10.1016/j.aca.2018.11.022" @default.
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