FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901304292> ?p ?o ?g. }

• W2901304292 abstract "Abstract Therapeutic seizures may work for treatment-resistant depression (TRD) by producing neuroplasticity. We evaluated whether magnetic seizure therapy (MST) produces changes in suicidal ideation and neuroplasticity as indexed through transcranial magnetic stimulation and electroencephalography (TMS-EEG) of the dorsolateral prefrontal cortex (DLPFC). Twenty-three patients with TRD were treated with MST. Changes in suicidal ideation was assessed through the Scale for Suicidal Ideation (SSI). Before and after the treatment course, neuroplasticity in excitatory and inhibitory circuits was assessed with TMS-EEG measures of cortical-evoked activity (CEA) and long-interval cortical inhibition (LICI) from the left DLPFC, and the left motor cortex as a control condition. As in our previous report, the relationship between TMS-EEG measures and suicidal ideation was examined with the SSI. Results show that 44.4% of patients experienced resolution of suicidal ideation. Based on DLPFC assessment, MST produced significant CEA increase over the frontal central electrodes (cluster p < 0.05), but did not change LICI on a group level. MST also reduced the SSI scores ( p < 0.005) and the amount of reduction correlated with the decrease in LICI over the right frontal central electrodes (cluster p < 0.05; rho = 0.73 for Cz). LICI change identified patients who were resolved of suicidal ideation with 90% sensitivity and 88% specificity (AUC = 0.9, p = 0.004). There was no significant finding with motor cortex assessment. Overall, MST produced significant rates of resolution of suicidal ideation. MST also produced neuroplasticity in the frontal cortex, likely through long-term potentiation (LTP)-like mechanisms. The largest reduction in suicidal ideation was demonstrated in patients showing concomitant decreases in cortical inhibition—a mechanism linked to enhanced LTP-like plasticity. These findings provide insights into the mechanisms through which patients experience resolution of suicidal ideation following seizure treatments in depression." @default.
• W2901304292 created "2018-11-29" @default.
• W2901304292 creator A5003880874 @default.
• W2901304292 creator A5004751576 @default.
• W2901304292 creator A5013816662 @default.
• W2901304292 creator A5015821361 @default.
• W2901304292 creator A5019562259 @default.
• W2901304292 creator A5021076203 @default.
• W2901304292 creator A5024382401 @default.
• W2901304292 creator A5039618500 @default.
• W2901304292 creator A5051880625 @default.
• W2901304292 creator A5064979886 @default.
• W2901304292 date "2018-11-23" @default.
• W2901304292 modified "2023-10-18" @default.
• W2901304292 title "Magnetic seizure therapy reduces suicidal ideation and produces neuroplasticity in treatment-resistant depression" @default.
• W2901304292 cites W1565295636 @default.
• W2901304292 cites W1968575969 @default.
• W2901304292 cites W1973530337 @default.
• W2901304292 cites W1974776346 @default.
• W2901304292 cites W1976072801 @default.
• W2901304292 cites W1977465442 @default.
• W2901304292 cites W1978891587 @default.
• W2901304292 cites W1995188451 @default.
• W2901304292 cites W1999967297 @default.
• W2901304292 cites W2000209446 @default.
• W2901304292 cites W2004240294 @default.
• W2901304292 cites W2012839705 @default.
• W2901304292 cites W2024799828 @default.
• W2901304292 cites W2025975629 @default.
• W2901304292 cites W2030957288 @default.
• W2901304292 cites W2031992483 @default.
• W2901304292 cites W2038404657 @default.
• W2901304292 cites W2048595403 @default.
• W2901304292 cites W2049785594 @default.
• W2901304292 cites W2061730652 @default.
• W2901304292 cites W2062895901 @default.
• W2901304292 cites W2064383989 @default.
• W2901304292 cites W2074522737 @default.
• W2901304292 cites W2085105520 @default.
• W2901304292 cites W2088099997 @default.
• W2901304292 cites W2103255996 @default.
• W2901304292 cites W2108554643 @default.
• W2901304292 cites W2114560574 @default.
• W2901304292 cites W2115492850 @default.
• W2901304292 cites W2119981100 @default.
• W2901304292 cites W2127297211 @default.
• W2901304292 cites W2132324173 @default.
• W2901304292 cites W2133565799 @default.
• W2901304292 cites W2136763742 @default.
• W2901304292 cites W2136869363 @default.
• W2901304292 cites W2140658729 @default.
• W2901304292 cites W2142470720 @default.
• W2901304292 cites W2142949314 @default.
• W2901304292 cites W2146935353 @default.
• W2901304292 cites W2148239264 @default.
• W2901304292 cites W2151179877 @default.
• W2901304292 cites W2156809536 @default.
• W2901304292 cites W2157504436 @default.
• W2901304292 cites W2159202946 @default.
• W2901304292 cites W2160603187 @default.
• W2901304292 cites W2168773701 @default.
• W2901304292 cites W2299043002 @default.
• W2901304292 cites W2414491533 @default.
• W2901304292 cites W2506603016 @default.
• W2901304292 cites W2528713311 @default.
• W2901304292 cites W4240718682 @default.
• W2901304292 cites W4243949016 @default.
• W2901304292 cites W4248307879 @default.
• W2901304292 doi "https://doi.org/10.1038/s41398-018-0302-8" @default.
• W2901304292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6251931" @default.
• W2901304292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30470735" @default.
• W2901304292 hasPublicationYear "2018" @default.
• W2901304292 type Work @default.
• W2901304292 sameAs 2901304292 @default.
• W2901304292 citedByCount "48" @default.
• W2901304292 countsByYear W29013042922019 @default.
• W2901304292 countsByYear W29013042922020 @default.
• W2901304292 countsByYear W29013042922021 @default.
• W2901304292 countsByYear W29013042922022 @default.
• W2901304292 countsByYear W29013042922023 @default.
• W2901304292 crossrefType "journal-article" @default.
• W2901304292 hasAuthorship W2901304292A5003880874 @default.
• W2901304292 hasAuthorship W2901304292A5004751576 @default.
• W2901304292 hasAuthorship W2901304292A5013816662 @default.
• W2901304292 hasAuthorship W2901304292A5015821361 @default.
• W2901304292 hasAuthorship W2901304292A5019562259 @default.
• W2901304292 hasAuthorship W2901304292A5021076203 @default.
• W2901304292 hasAuthorship W2901304292A5024382401 @default.
• W2901304292 hasAuthorship W2901304292A5039618500 @default.
• W2901304292 hasAuthorship W2901304292A5051880625 @default.
• W2901304292 hasAuthorship W2901304292A5064979886 @default.
• W2901304292 hasBestOaLocation W29013042921 @default.
• W2901304292 hasConcept C118552586 @default.
• W2901304292 hasConcept C126322002 @default.
• W2901304292 hasConcept C15744967 @default.
• W2901304292 hasConcept C169760540 @default.
• W2901304292 hasConcept C169900460 @default.
• W2901304292 hasConcept C190385971 @default.
• W2901304292 hasConcept C24998067 @default.
• W2901304292 hasConcept C2776412080 @default.

• next