FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901307472> ?p ?o ?g. }

• W2901307472 endingPage "245" @default.
• W2901307472 startingPage "233" @default.
• W2901307472 abstract "Tilianin, a naturally occurring flavonoid glycoside, possesses versatile biological activities including antioxidant, anti-inflammatory, energy collecting and anti-hypoxic effects. Little is known about the mechanisms underlying the effect of tilianin against ischemic injury in neuronal cells. We aimed to determine the potential targets and mechanisms of tilianin treatment behind the crosstalk pathways induced by oxygen-glucose deprivation (OGD). We used an in silico docking model for interaction mode analysis and in vitro models for mechanistic exploration and target verification. Protein changes were measured using cellular immunofluorescence and ELISA techniques. The ability of tilianin to promote recovery of OGD-induced neurocytotoxic injury was demonstrated by maintenance of cell viability, membrane integrity and nuclear homogeneity. Tilianin treatment was also found to balance the concentrations of proapoptotic and antiapoptotic proteins that had been modified by OGD-induced mitochondrial dysfunction. Of these intersectional cascades, Ca2+/calmodulin-dependent protein kinase II (CaMKII) was found to bind efficiently with tilianin. This presented a certain binding score along with down-regulation of ox-CaMKII and p-CaMKII in SH-SY5Y cells affected by OGD. Importantly, after utilizing KN93, one specific CaMKII inhibitor, tilianin-mediated neuroprotection against OGD was abolished. This effect was accompanied by upregulation of mitochondrial function. Thus, the beneficial effects of tilianin toward mitochondrion-mediated apoptosis and p38/JNK/NF-κB-associated inflammatory pathways were reversed following CaMKII inhibition. Our study indicated that attenuation of CaMKII-linked signaling mediated through mitochondria and p38/JNK/NF-κB inflammatory pathways is a key mechanism by which tilianin exerts its neuroprotective effects against cerebral ischemia." @default.
• W2901307472 created "2018-11-29" @default.
• W2901307472 creator A5006245466 @default.
• W2901307472 creator A5014298605 @default.
• W2901307472 creator A5019707913 @default.
• W2901307472 creator A5026928088 @default.
• W2901307472 creator A5029470846 @default.
• W2901307472 creator A5039891570 @default.
• W2901307472 creator A5066573930 @default.
• W2901307472 creator A5084360073 @default.
• W2901307472 date "2019-01-01" @default.
• W2901307472 modified "2023-10-01" @default.
• W2901307472 title "Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII-dependent mitochondrion-mediated apoptosis and MAPK/NF-κB signaling" @default.
• W2901307472 cites W1976246640 @default.
• W2901307472 cites W1985939052 @default.
• W2901307472 cites W1987046506 @default.
• W2901307472 cites W1988005040 @default.
• W2901307472 cites W2003242423 @default.
• W2901307472 cites W2008757142 @default.
• W2901307472 cites W2010980945 @default.
• W2901307472 cites W2013380034 @default.
• W2901307472 cites W2013717577 @default.
• W2901307472 cites W2024035512 @default.
• W2901307472 cites W2030044573 @default.
• W2901307472 cites W2041471383 @default.
• W2901307472 cites W2118444707 @default.
• W2901307472 cites W2139242531 @default.
• W2901307472 cites W2166686805 @default.
• W2901307472 cites W2399882212 @default.
• W2901307472 cites W2742243294 @default.
• W2901307472 cites W2766538169 @default.
• W2901307472 cites W2789308395 @default.
• W2901307472 cites W2802854165 @default.
• W2901307472 cites W2808838098 @default.
• W2901307472 cites W2883002308 @default.
• W2901307472 cites W371723124 @default.
• W2901307472 cites W4240214838 @default.
• W2901307472 doi "https://doi.org/10.1016/j.lfs.2018.11.035" @default.
• W2901307472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30472297" @default.
• W2901307472 hasPublicationYear "2019" @default.
• W2901307472 type Work @default.
• W2901307472 sameAs 2901307472 @default.
• W2901307472 citedByCount "23" @default.
• W2901307472 countsByYear W29013074722019 @default.
• W2901307472 countsByYear W29013074722020 @default.
• W2901307472 countsByYear W29013074722021 @default.
• W2901307472 countsByYear W29013074722022 @default.
• W2901307472 countsByYear W29013074722023 @default.
• W2901307472 crossrefType "journal-article" @default.
• W2901307472 hasAuthorship W2901307472A5006245466 @default.
• W2901307472 hasAuthorship W2901307472A5014298605 @default.
• W2901307472 hasAuthorship W2901307472A5019707913 @default.
• W2901307472 hasAuthorship W2901307472A5026928088 @default.
• W2901307472 hasAuthorship W2901307472A5029470846 @default.
• W2901307472 hasAuthorship W2901307472A5039891570 @default.
• W2901307472 hasAuthorship W2901307472A5066573930 @default.
• W2901307472 hasAuthorship W2901307472A5084360073 @default.
• W2901307472 hasConcept C104317684 @default.
• W2901307472 hasConcept C127561419 @default.
• W2901307472 hasConcept C185592680 @default.
• W2901307472 hasConcept C190283241 @default.
• W2901307472 hasConcept C25498285 @default.
• W2901307472 hasConcept C28859421 @default.
• W2901307472 hasConcept C51551487 @default.
• W2901307472 hasConcept C55493867 @default.
• W2901307472 hasConcept C57074206 @default.
• W2901307472 hasConcept C62478195 @default.
• W2901307472 hasConcept C86803240 @default.
• W2901307472 hasConcept C95444343 @default.
• W2901307472 hasConcept C98274493 @default.
• W2901307472 hasConceptScore W2901307472C104317684 @default.
• W2901307472 hasConceptScore W2901307472C127561419 @default.
• W2901307472 hasConceptScore W2901307472C185592680 @default.
• W2901307472 hasConceptScore W2901307472C190283241 @default.
• W2901307472 hasConceptScore W2901307472C25498285 @default.
• W2901307472 hasConceptScore W2901307472C28859421 @default.
• W2901307472 hasConceptScore W2901307472C51551487 @default.
• W2901307472 hasConceptScore W2901307472C55493867 @default.
• W2901307472 hasConceptScore W2901307472C57074206 @default.
• W2901307472 hasConceptScore W2901307472C62478195 @default.
• W2901307472 hasConceptScore W2901307472C86803240 @default.
• W2901307472 hasConceptScore W2901307472C95444343 @default.
• W2901307472 hasConceptScore W2901307472C98274493 @default.
• W2901307472 hasFunder F4320321001 @default.
• W2901307472 hasFunder F4320323137 @default.
• W2901307472 hasFunder F4320326853 @default.
• W2901307472 hasLocation W29013074721 @default.
• W2901307472 hasLocation W29013074722 @default.
• W2901307472 hasOpenAccess W2901307472 @default.
• W2901307472 hasPrimaryLocation W29013074721 @default.
• W2901307472 hasRelatedWork W1567517482 @default.
• W2901307472 hasRelatedWork W1982046254 @default.
• W2901307472 hasRelatedWork W2004726042 @default.
• W2901307472 hasRelatedWork W2049435255 @default.
• W2901307472 hasRelatedWork W2348771880 @default.
• W2901307472 hasRelatedWork W2349677430 @default.
• W2901307472 hasRelatedWork W2381340599 @default.
• W2901307472 hasRelatedWork W2521782501 @default.

• next