FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901309087> ?p ?o ?g. }

• W2901309087 endingPage "1285" @default.
• W2901309087 startingPage "1277" @default.
• W2901309087 abstract "Background. The endothelial glycocalyx, a sieve-like structure located on the luminal surface of all blood vessels, has been found to be integral to regulation of capillary permeability and mechanotransduction. Given this, we investigated the role of endothelial glycocalyx breakdown products in organ donors and recipients in terms of acceptability for transplant and risk of primary graft dysfunction (PGD). Methods. Endothelial glycocalyx breakdown products were measured in the peripheral blood of 135 intended and actual organ donors. Breakdown product levels were tested for association with donor demographic and clinical data, organ acceptability for transplant along with lung recipient outcomes (n = 35). Liquid chromatography mass spectrometry analysis was performed to confirm glycosaminoglycan levels and sulfation patterns on donor samples (n = 15). In transplant recipients (n = 50), levels were measured pretransplant and daily for 4 days posttransplant. Levels were correlated with PGD severity and intubation time. Results. Decreased hyaluronan levels in peripheral blood independently predicted organ acceptability in intended and actual donors (odds ratio, 0.96; [95% confidence interval, 0.93–0.99] P = 0.026). Furthermore, high donor syndecan-1 levels were associated with PGD in recipients (3142 [1575–4829] versus 6229 [4009–8093] pg/mL; P = 0.045). In recipient blood, levels of syndecan-1 were correlated with severe (grades 2–3) PGD at 72 hours posttransplant (5982 [3016–17191] versus 3060 [2005–4824] pg/mL; P = 0.01). Conclusions. Endothelial glycocalyx breakdown occurs in lung transplant donors and recipients and predicts organ acceptability and development of PGD. Glycocalyx breakdown products may be useful biomarkers in transplantation, and interventions to protect the glycocalyx could improve transplant outcomes." @default.
• W2901309087 created "2018-11-29" @default.
• W2901309087 creator A5006413215 @default.
• W2901309087 creator A5009766005 @default.
• W2901309087 creator A5039211752 @default.
• W2901309087 creator A5047234331 @default.
• W2901309087 creator A5051504721 @default.
• W2901309087 creator A5052585611 @default.
• W2901309087 creator A5056210370 @default.
• W2901309087 creator A5058877409 @default.
• W2901309087 creator A5069724772 @default.
• W2901309087 date "2019-06-01" @default.
• W2901309087 modified "2023-10-02" @default.
• W2901309087 title "Endothelial Glycocalyx Shedding Predicts Donor Organ Acceptability and Is Associated With Primary Graft Dysfunction in Lung Transplant Recipients" @default.
• W2901309087 cites W1561436010 @default.
• W2901309087 cites W1710550832 @default.
• W2901309087 cites W1965623500 @default.
• W2901309087 cites W1965848751 @default.
• W2901309087 cites W1970696225 @default.
• W2901309087 cites W1983688860 @default.
• W2901309087 cites W1986727315 @default.
• W2901309087 cites W1989148258 @default.
• W2901309087 cites W1990526178 @default.
• W2901309087 cites W1992644453 @default.
• W2901309087 cites W2000549992 @default.
• W2901309087 cites W2006006000 @default.
• W2901309087 cites W2010714117 @default.
• W2901309087 cites W2013127121 @default.
• W2901309087 cites W2022261611 @default.
• W2901309087 cites W2024921895 @default.
• W2901309087 cites W2033576968 @default.
• W2901309087 cites W2034248554 @default.
• W2901309087 cites W2040242558 @default.
• W2901309087 cites W2047136147 @default.
• W2901309087 cites W2052798492 @default.
• W2901309087 cites W2056865880 @default.
• W2901309087 cites W2061506885 @default.
• W2901309087 cites W2061626698 @default.
• W2901309087 cites W2063932484 @default.
• W2901309087 cites W2073214088 @default.
• W2901309087 cites W2073264366 @default.
• W2901309087 cites W2073912003 @default.
• W2901309087 cites W2074887602 @default.
• W2901309087 cites W2076769607 @default.
• W2901309087 cites W2079036820 @default.
• W2901309087 cites W2079748904 @default.
• W2901309087 cites W2087589015 @default.
• W2901309087 cites W2089707802 @default.
• W2901309087 cites W2094164955 @default.
• W2901309087 cites W2096494856 @default.
• W2901309087 cites W2097000915 @default.
• W2901309087 cites W2098274894 @default.
• W2901309087 cites W2099601490 @default.
• W2901309087 cites W2110707896 @default.
• W2901309087 cites W2111766323 @default.
• W2901309087 cites W2115039765 @default.
• W2901309087 cites W2120454293 @default.
• W2901309087 cites W2122398024 @default.
• W2901309087 cites W2123420912 @default.
• W2901309087 cites W2127172433 @default.
• W2901309087 cites W2140216738 @default.
• W2901309087 cites W2141149908 @default.
• W2901309087 cites W2145415920 @default.
• W2901309087 cites W2148230934 @default.
• W2901309087 cites W2152252241 @default.
• W2901309087 cites W2152678130 @default.
• W2901309087 cites W2153479733 @default.
• W2901309087 cites W2153870838 @default.
• W2901309087 cites W2153978059 @default.
• W2901309087 cites W2158325787 @default.
• W2901309087 cites W2162312379 @default.
• W2901309087 cites W2163038896 @default.
• W2901309087 cites W2166411176 @default.
• W2901309087 cites W2167527394 @default.
• W2901309087 cites W2171745766 @default.
• W2901309087 cites W2172154057 @default.
• W2901309087 cites W2325567818 @default.
• W2901309087 cites W2510169643 @default.
• W2901309087 doi "https://doi.org/10.1097/tp.0000000000002539" @default.
• W2901309087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30444804" @default.
• W2901309087 hasPublicationYear "2019" @default.
• W2901309087 type Work @default.
• W2901309087 sameAs 2901309087 @default.
• W2901309087 citedByCount "20" @default.
• W2901309087 countsByYear W29013090872019 @default.
• W2901309087 countsByYear W29013090872020 @default.
• W2901309087 countsByYear W29013090872021 @default.
• W2901309087 countsByYear W29013090872022 @default.
• W2901309087 countsByYear W29013090872023 @default.
• W2901309087 crossrefType "journal-article" @default.
• W2901309087 hasAuthorship W2901309087A5006413215 @default.
• W2901309087 hasAuthorship W2901309087A5009766005 @default.
• W2901309087 hasAuthorship W2901309087A5039211752 @default.
• W2901309087 hasAuthorship W2901309087A5047234331 @default.
• W2901309087 hasAuthorship W2901309087A5051504721 @default.
• W2901309087 hasAuthorship W2901309087A5052585611 @default.
• W2901309087 hasAuthorship W2901309087A5056210370 @default.
• W2901309087 hasAuthorship W2901309087A5058877409 @default.

• next