FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W290132061> ?p ?o ?g. }

• W290132061 endingPage "250" @default.
• W290132061 startingPage "238" @default.
• W290132061 abstract "Reactive astrogliosis impedes axonal regeneration after injuries to the mammalian central nervous system (CNS). Here we report that glial cell line-derived neurotrophic factor (GDNF), combined with transplanted Schwann cells (SCs), effectively reversed the inhibitory properties of astrocytes at graft-host interfaces allowing robust axonal regeneration, concomitant with vigorous migration of host astrocytes into SC-seeded semi-permeable guidance channels implanted into a right-sided spinal cord hemisection at the 10th thoracic (T10) level. Within the graft, migrated host astrocytes were in close association with regenerated axons. Astrocyte processes extended parallel to the axons, implying that the migrated astrocytes were not inhibitory and might have promoted directional growth of regenerated axons. In vitro, GDNF induced migration of SCs and astrocytes toward each other in an astrocyte-SC confrontation assay. GDNF also enhanced migration of astrocytes on a SC monolayer in an inverted coverslip migration assay, suggesting that this effect is mediated by direct cell-cell contact between the two cell types. Morphologically, GDNF administration reduced astrocyte hypertrophy and induced elongated process extension of these cells, similar to what was observed in vivo. Notably, GDNF treatment significantly reduced production of glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycans (CSPGs), two hallmarks of astrogliosis, in both the in vivo and in vitro models. Thus, our study demonstrates a novel role of GDNF in modifying spinal cord injury (SCI)-induced astrogliosis resulting in robust axonal regeneration in adult rats." @default.
• W290132061 created "2016-06-24" @default.
• W290132061 creator A5011097362 @default.
• W290132061 creator A5018686845 @default.
• W290132061 creator A5020223373 @default.
• W290132061 creator A5028702225 @default.
• W290132061 creator A5064647180 @default.
• W290132061 creator A5071875932 @default.
• W290132061 creator A5091652696 @default.
• W290132061 date "2011-06-01" @default.
• W290132061 modified "2023-10-15" @default.
• W290132061 title "GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury" @default.
• W290132061 cites W1004096992 @default.
• W290132061 cites W1553578897 @default.
• W290132061 cites W1566611926 @default.
• W290132061 cites W1603255570 @default.
• W290132061 cites W1826719783 @default.
• W290132061 cites W1916238061 @default.
• W290132061 cites W1964801456 @default.
• W290132061 cites W1971713732 @default.
• W290132061 cites W1975685140 @default.
• W290132061 cites W1976594128 @default.
• W290132061 cites W1978430149 @default.
• W290132061 cites W1979529470 @default.
• W290132061 cites W1980329061 @default.
• W290132061 cites W1983712592 @default.
• W290132061 cites W1984902146 @default.
• W290132061 cites W1986574486 @default.
• W290132061 cites W1995729951 @default.
• W290132061 cites W1998885927 @default.
• W290132061 cites W2009259931 @default.
• W290132061 cites W2011387965 @default.
• W290132061 cites W2012928251 @default.
• W290132061 cites W2015541518 @default.
• W290132061 cites W2024081088 @default.
• W290132061 cites W2024800084 @default.
• W290132061 cites W2032985825 @default.
• W290132061 cites W2034337978 @default.
• W290132061 cites W2036101427 @default.
• W290132061 cites W2037059852 @default.
• W290132061 cites W2038477687 @default.
• W290132061 cites W2057669829 @default.
• W290132061 cites W2057974205 @default.
• W290132061 cites W2060111610 @default.
• W290132061 cites W2061348706 @default.
• W290132061 cites W2061735753 @default.
• W290132061 cites W2065013459 @default.
• W290132061 cites W2066768537 @default.
• W290132061 cites W2068027246 @default.
• W290132061 cites W2071327579 @default.
• W290132061 cites W2077738152 @default.
• W290132061 cites W2081895884 @default.
• W290132061 cites W2088007682 @default.
• W290132061 cites W2088885861 @default.
• W290132061 cites W2089741801 @default.
• W290132061 cites W2090856415 @default.
• W290132061 cites W2091845372 @default.
• W290132061 cites W2104968232 @default.
• W290132061 cites W2108724455 @default.
• W290132061 cites W2118427313 @default.
• W290132061 cites W2122757851 @default.
• W290132061 cites W2122781484 @default.
• W290132061 cites W2135376726 @default.
• W290132061 cites W2141767464 @default.
• W290132061 cites W2144502179 @default.
• W290132061 cites W2170828389 @default.
• W290132061 cites W77384000 @default.
• W290132061 doi "https://doi.org/10.1016/j.expneurol.2011.02.001" @default.
• W290132061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3100372" @default.
• W290132061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21316362" @default.
• W290132061 hasPublicationYear "2011" @default.
• W290132061 type Work @default.
• W290132061 sameAs 290132061 @default.
• W290132061 citedByCount "101" @default.
• W290132061 countsByYear W2901320612012 @default.
• W290132061 countsByYear W2901320612013 @default.
• W290132061 countsByYear W2901320612014 @default.
• W290132061 countsByYear W2901320612015 @default.
• W290132061 countsByYear W2901320612016 @default.
• W290132061 countsByYear W2901320612017 @default.
• W290132061 countsByYear W2901320612018 @default.
• W290132061 countsByYear W2901320612019 @default.
• W290132061 countsByYear W2901320612020 @default.
• W290132061 countsByYear W2901320612021 @default.
• W290132061 countsByYear W2901320612022 @default.
• W290132061 countsByYear W2901320612023 @default.
• W290132061 crossrefType "journal-article" @default.
• W290132061 hasAuthorship W290132061A5011097362 @default.
• W290132061 hasAuthorship W290132061A5018686845 @default.
• W290132061 hasAuthorship W290132061A5020223373 @default.
• W290132061 hasAuthorship W290132061A5028702225 @default.
• W290132061 hasAuthorship W290132061A5064647180 @default.
• W290132061 hasAuthorship W290132061A5071875932 @default.
• W290132061 hasAuthorship W290132061A5091652696 @default.
• W290132061 hasBestOaLocation W2901320612 @default.
• W290132061 hasConcept C160539049 @default.
• W290132061 hasConcept C169760540 @default.
• W290132061 hasConcept C170493617 @default.

• next