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• W2901331365 endingPage "1918" @default.
• W2901331365 startingPage "1901" @default.
• W2901331365 abstract "Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug resistance. However, available genome-wide methods have a limited ability to resolve rare somatic variants and the relationships between these variants. Here, we present lineage sequencing, a new genome sequencing approach that enables somatic event reconstruction by providing quality somatic mutation call sets with resolution as high as the single-cell level in subject lineages. Lineage sequencing entails sampling single cells from a population and sequencing subclonal sample sets derived from these cells such that knowledge of relationships among the cells can be used to jointly call variants across the sample set. This approach integrates data from multiple sequence libraries to support each variant and precisely assigns mutations to lineage segments. We applied lineage sequencing to a human colon cancer cell line with a DNA polymerase epsilon ( POLE ) proofreading deficiency (HT115) and a human retinal epithelial cell line immortalized by constitutive telomerase expression (RPE1). Cells were cultured under continuous observation to link observed single-cell phenotypes with single-cell mutation data. The high sensitivity, specificity, and resolution of the data provide a unique opportunity for quantitative analysis of variation in mutation rate, spectrum, and correlations among variants. Our data show that mutations arrive with nonuniform probability across sublineages and that DNA lesion dynamics may cause strong correlations between certain mutations." @default.
• W2901331365 created "2018-11-29" @default.
• W2901331365 creator A5001392592 @default.
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• W2901331365 creator A5073123534 @default.
• W2901331365 creator A5079809176 @default.
• W2901331365 creator A5086771704 @default.
• W2901331365 date "2018-11-20" @default.
• W2901331365 modified "2023-10-17" @default.
• W2901331365 title "Quantification of somatic mutation flow across individual cell division events by lineage sequencing" @default.
• W2901331365 cites W1630303999 @default.
• W2901331365 cites W1956871134 @default.
• W2901331365 cites W1976848056 @default.
• W2901331365 cites W1980745500 @default.
• W2901331365 cites W1985561503 @default.
• W2901331365 cites W1989298969 @default.
• W2901331365 cites W2008255210 @default.
• W2901331365 cites W2034694386 @default.
• W2901331365 cites W2042793731 @default.
• W2901331365 cites W2043398720 @default.
• W2901331365 cites W2052954221 @default.
• W2901331365 cites W2072691491 @default.
• W2901331365 cites W2078485114 @default.
• W2901331365 cites W2107356675 @default.
• W2901331365 cites W2107903949 @default.
• W2901331365 cites W2108482850 @default.
• W2901331365 cites W2113986107 @default.
• W2901331365 cites W2114023704 @default.
• W2901331365 cites W2118151336 @default.
• W2901331365 cites W2120807753 @default.
• W2901331365 cites W2121356457 @default.
• W2901331365 cites W2127604631 @default.
• W2901331365 cites W2138601221 @default.
• W2901331365 cites W2142096492 @default.
• W2901331365 cites W2143197030 @default.
• W2901331365 cites W2146290346 @default.
• W2901331365 cites W2147152088 @default.
• W2901331365 cites W2151757310 @default.
• W2901331365 cites W2152061559 @default.
• W2901331365 cites W2153027378 @default.
• W2901331365 cites W2155453721 @default.
• W2901331365 cites W2156407908 @default.
• W2901331365 cites W2157285575 @default.
• W2901331365 cites W2159999673 @default.
• W2901331365 cites W2161188902 @default.
• W2901331365 cites W2168142506 @default.
• W2901331365 cites W2168656450 @default.
• W2901331365 cites W2171412952 @default.
• W2901331365 cites W2172896922 @default.
• W2901331365 cites W2201797518 @default.
• W2901331365 cites W2204695746 @default.
• W2901331365 cites W2210259689 @default.
• W2901331365 cites W2218943248 @default.
• W2901331365 cites W2266041843 @default.
• W2901331365 cites W2269040222 @default.
• W2901331365 cites W2294814189 @default.
• W2901331365 cites W2302476265 @default.
• W2901331365 cites W2322936137 @default.
• W2901331365 cites W2343368549 @default.
• W2901331365 cites W2345503748 @default.
• W2901331365 cites W2347107809 @default.
• W2901331365 cites W2406991867 @default.
• W2901331365 cites W2415913162 @default.
• W2901331365 cites W2490493873 @default.
• W2901331365 cites W2498989218 @default.
• W2901331365 cites W2524881570 @default.
• W2901331365 cites W2549892365 @default.
• W2901331365 cites W2553830626 @default.
• W2901331365 cites W2557069473 @default.
• W2901331365 cites W2580767916 @default.
• W2901331365 cites W2581340604 @default.
• W2901331365 cites W2581568937 @default.
• W2901331365 cites W2586629973 @default.
• W2901331365 cites W2603764892 @default.
• W2901331365 cites W2605512081 @default.
• W2901331365 cites W2608500349 @default.
• W2901331365 cites W2613868166 @default.
• W2901331365 cites W2616998305 @default.
• W2901331365 cites W2740561900 @default.
• W2901331365 cites W2744312029 @default.
• W2901331365 cites W2746288782 @default.
• W2901331365 cites W2755775794 @default.
• W2901331365 cites W2757175218 @default.
• W2901331365 cites W2765468373 @default.
• W2901331365 cites W2767322731 @default.
• W2901331365 cites W2774506962 @default.
• W2901331365 cites W2792407191 @default.
• W2901331365 cites W2795652047 @default.
• W2901331365 cites W2795993993 @default.
• W2901331365 cites W2799563655 @default.

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