FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901361805> ?p ?o ?g. }

• W2901361805 abstract "Background: Hemorrhagic shock and volume replacement can alter coagulation. Synthetic colloids, hydroxyethyl starch (HES), and gelatin, may enhance hypocoagulability. Our primary objective was to describe the effect of four fluid products on coagulation in canine hemorrhagic shock. Our secondary objective was to compare measurements of coagulation during shock to baseline in all dogs. Methods: Anesthetized greyhounds subjected to atraumatic hemorrhage for 60 min were administered 20 mL kg-1 of either fresh whole blood (FWB), 6% HES 130/0.4, 4% succinylated gelatin (GELO), or 80 mL kg-1 of isotonic crystalloid over 20 min (n = 6 per group). Platelet closure time (PCT), rotational thromboelastometry (ROTEM) and plasma coagulation assays were measured at baseline, end of hemorrhage (shock), and 40 (T60), and 160 (T180) min after study fluid. ROTEM parameters included clotting time (CT), clot formation time (CFT), alpha angle, maximum clot firmness (MCF), lysis index at 60 min (LI60), and thrombodynamic potential index (TPI) for INTEM, EXTEM, FIBTEM (MCF only), and APTEM (LI60 only) profiles. Plasma coagulation assays included prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen concentration and activities of factor VII (FVII), factor VIII (FVIII), and von Willebrand Factor antigen (vWF). Between-group differences were tested using linear mixed models with post-hoc between-group comparisons (Bonferroni-Holm corrected). Differences between baseline and shock were tested using paired t-tests. Significance was set at P < 0.05. Results: GELO showed longer PCT at T60, compared with FWB and CRYST, and at T180, compared with all other groups. HES showed longer EXTEM CT at T60, compared with all other groups. HES showed lower INTEM and EXTEM MCF at T60 and lower INTEM MCF at T180, compared with FWB. Some plasma coagulation assays showed greater hypocoagulability with HES. Comparing shock to baseline, EXTEM CT, INTEM CFT, EXTEM CFT, PT, and FVIII significantly increased and PCT, INTEM CT, INTEM MCF, EXTEM MCF, EXTEM LI60, EXTEM TPI, FIBTEM MCF, APTT, fibrinogen, FVII, and vWF significantly decreased. Conclusions: In dogs with hemorrhagic shock, volume replacement with GELO caused mild platelet dysfunction and HES was associated with coagulation changes consistent with hypocoagulability, beyond effects of hemodilution. Shock alone produced some evidence of hypocoagulability." @default.
• W2901361805 created "2018-11-29" @default.
• W2901361805 creator A5031066318 @default.
• W2901361805 creator A5038539349 @default.
• W2901361805 creator A5041872862 @default.
• W2901361805 creator A5049283486 @default.
• W2901361805 creator A5073271930 @default.
• W2901361805 creator A5080552055 @default.
• W2901361805 date "2018-11-13" @default.
• W2901361805 modified "2023-10-03" @default.
• W2901361805 title "Hypocoagulability and Platelet Dysfunction Are Exacerbated by Synthetic Colloids in a Canine Hemorrhagic Shock Model" @default.
• W2901361805 cites W1498765307 @default.
• W2901361805 cites W1573922084 @default.
• W2901361805 cites W1589110294 @default.
• W2901361805 cites W1631418919 @default.
• W2901361805 cites W1814055689 @default.
• W2901361805 cites W1867016089 @default.
• W2901361805 cites W1895140815 @default.
• W2901361805 cites W1960169587 @default.
• W2901361805 cites W1974157302 @default.
• W2901361805 cites W1982839578 @default.
• W2901361805 cites W1985486697 @default.
• W2901361805 cites W1991807372 @default.
• W2901361805 cites W2008898838 @default.
• W2901361805 cites W2035956989 @default.
• W2901361805 cites W2041681918 @default.
• W2901361805 cites W2053044018 @default.
• W2901361805 cites W2059103024 @default.
• W2901361805 cites W2070101854 @default.
• W2901361805 cites W2081297541 @default.
• W2901361805 cites W2088702086 @default.
• W2901361805 cites W2088977315 @default.
• W2901361805 cites W2097277074 @default.
• W2901361805 cites W2103413142 @default.
• W2901361805 cites W2107392960 @default.
• W2901361805 cites W2107732057 @default.
• W2901361805 cites W2110726812 @default.
• W2901361805 cites W2117257025 @default.
• W2901361805 cites W2126519077 @default.
• W2901361805 cites W2139431842 @default.
• W2901361805 cites W2143188199 @default.
• W2901361805 cites W2147101153 @default.
• W2901361805 cites W2151733424 @default.
• W2901361805 cites W2165264387 @default.
• W2901361805 cites W2167985603 @default.
• W2901361805 cites W2169096005 @default.
• W2901361805 cites W2274495469 @default.
• W2901361805 cites W2310511432 @default.
• W2901361805 cites W2338983078 @default.
• W2901361805 cites W2478446461 @default.
• W2901361805 cites W2527866572 @default.
• W2901361805 cites W2528828353 @default.
• W2901361805 cites W2557470146 @default.
• W2901361805 cites W2560774023 @default.
• W2901361805 cites W2610880231 @default.
• W2901361805 cites W2613664684 @default.
• W2901361805 cites W2752024323 @default.
• W2901361805 cites W2802750040 @default.
• W2901361805 cites W2149915185 @default.
• W2901361805 cites W2592409702 @default.
• W2901361805 doi "https://doi.org/10.3389/fvets.2018.00279" @default.
• W2901361805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7506514" @default.
• W2901361805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33102561" @default.
• W2901361805 hasPublicationYear "2018" @default.
• W2901361805 type Work @default.
• W2901361805 sameAs 2901361805 @default.
• W2901361805 citedByCount "24" @default.
• W2901361805 countsByYear W29013618052019 @default.
• W2901361805 countsByYear W29013618052020 @default.
• W2901361805 countsByYear W29013618052021 @default.
• W2901361805 countsByYear W29013618052022 @default.
• W2901361805 countsByYear W29013618052023 @default.
• W2901361805 crossrefType "journal-article" @default.
• W2901361805 hasAuthorship W2901361805A5031066318 @default.
• W2901361805 hasAuthorship W2901361805A5038539349 @default.
• W2901361805 hasAuthorship W2901361805A5041872862 @default.
• W2901361805 hasAuthorship W2901361805A5049283486 @default.
• W2901361805 hasAuthorship W2901361805A5073271930 @default.
• W2901361805 hasAuthorship W2901361805A5080552055 @default.
• W2901361805 hasBestOaLocation W29013618051 @default.
• W2901361805 hasConcept C126322002 @default.
• W2901361805 hasConcept C16124881 @default.
• W2901361805 hasConcept C185592680 @default.
• W2901361805 hasConcept C26809991 @default.
• W2901361805 hasConcept C2778261982 @default.
• W2901361805 hasConcept C2778382381 @default.
• W2901361805 hasConcept C2779412105 @default.
• W2901361805 hasConcept C2780434524 @default.
• W2901361805 hasConcept C2781300812 @default.
• W2901361805 hasConcept C42219234 @default.
• W2901361805 hasConcept C71924100 @default.
• W2901361805 hasConcept C77171857 @default.
• W2901361805 hasConcept C89560881 @default.
• W2901361805 hasConceptScore W2901361805C126322002 @default.
• W2901361805 hasConceptScore W2901361805C16124881 @default.
• W2901361805 hasConceptScore W2901361805C185592680 @default.
• W2901361805 hasConceptScore W2901361805C26809991 @default.
• W2901361805 hasConceptScore W2901361805C2778261982 @default.
• W2901361805 hasConceptScore W2901361805C2778382381 @default.
• W2901361805 hasConceptScore W2901361805C2779412105 @default.

• next