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• W2901363609 endingPage "15" @default.
• W2901363609 startingPage "1" @default.
• W2901363609 abstract "Evidence demonstrated that the glutamatergic system is implicated in mediating relapse to several drugs of abuse, including methamphetamine (METH). Glutamate homeostasis is maintained by a number of glutamate transporters, such as glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). In addition, group II metabotropic glutamate receptors (mGluR2/3) were found to be implicated in relapse-seeking behavior. Ample evidence showed that β-lactam antibiotics are effective in upregulating GLT-1 and xCT expression, thus improving glutamate homeostasis and attenuating relapse to drugs of abuse. In this study, we investigated the reinstatement of METH using conditioned place preference (CPP) in male alcohol-preferring (P) rats exposed to home-cage free choice ethanol drinking. Here, we tested the effect of clavulanic acid (CA), a β-lactam, on the reinstatement of METH-seeking and ethanol drinking. In addition, we examined the expression of GLT-1, xCT, and GLAST as well as metabotropic glutamate receptor (mGluR2/3) in the nucleus accumbens (NAc) shell, NAc core, and dorsomedial prefrontal cortex (dmPFC). A priming i.p. injection of METH reinstated preference in METH-paired chamber following extinction. Chronic exposure to ethanol decreased the expression of GLT-1 and xCT in the NAc shell, but not in the NAc core or dmPFC. CA treatment blocked the reinstatement of METH-seeking, decreased ethanol intake, and restored the expression of GLT-1 and xCT in the NAc shell. In addition, the expression of mGluR2/3 was increased by CA treatment in the NAc shell and dmPFC. These findings suggest that these glutamate transporters and mGluR2/3 might be potential therapeutic targets for the attenuation of reinstatement to METH-seeking." @default.
• W2901363609 created "2018-11-29" @default.
• W2901363609 creator A5002549713 @default.
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• W2901363609 creator A5040307540 @default.
• W2901363609 creator A5073338828 @default.
• W2901363609 creator A5090444613 @default.
• W2901363609 date "2018-11-23" @default.
• W2901363609 modified "2023-09-25" @default.
• W2901363609 title "Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol" @default.
• W2901363609 cites W1512575453 @default.
• W2901363609 cites W1556418042 @default.
• W2901363609 cites W1592375995 @default.
• W2901363609 cites W1605897432 @default.
• W2901363609 cites W1889428062 @default.
• W2901363609 cites W1894867663 @default.
• W2901363609 cites W1918535853 @default.
• W2901363609 cites W1963790626 @default.
• W2901363609 cites W1964076471 @default.
• W2901363609 cites W1965672705 @default.
• W2901363609 cites W1966157739 @default.
• W2901363609 cites W1966449636 @default.
• W2901363609 cites W1968490092 @default.
• W2901363609 cites W1969317435 @default.
• W2901363609 cites W1971395818 @default.
• W2901363609 cites W1975247126 @default.
• W2901363609 cites W1977430058 @default.
• W2901363609 cites W1977850361 @default.
• W2901363609 cites W1978222306 @default.
• W2901363609 cites W1978723069 @default.
• W2901363609 cites W1978862106 @default.
• W2901363609 cites W1981444301 @default.
• W2901363609 cites W1981505515 @default.
• W2901363609 cites W1983959076 @default.
• W2901363609 cites W1993440125 @default.
• W2901363609 cites W1995606936 @default.
• W2901363609 cites W1997394823 @default.
• W2901363609 cites W2000607451 @default.
• W2901363609 cites W2000825098 @default.
• W2901363609 cites W2003410399 @default.
• W2901363609 cites W2009740212 @default.
• W2901363609 cites W2010267467 @default.
• W2901363609 cites W2016575029 @default.
• W2901363609 cites W2026776322 @default.
• W2901363609 cites W2030687244 @default.
• W2901363609 cites W2034150217 @default.
• W2901363609 cites W2034224022 @default.
• W2901363609 cites W2036131176 @default.
• W2901363609 cites W2036934626 @default.
• W2901363609 cites W2037223620 @default.
• W2901363609 cites W2038566061 @default.
• W2901363609 cites W2038772185 @default.
• W2901363609 cites W2043819248 @default.
• W2901363609 cites W2045185962 @default.
• W2901363609 cites W2046653976 @default.
• W2901363609 cites W2051554010 @default.
• W2901363609 cites W2052205730 @default.
• W2901363609 cites W2057536623 @default.
• W2901363609 cites W2061161259 @default.
• W2901363609 cites W2064323618 @default.
• W2901363609 cites W2068735847 @default.
• W2901363609 cites W2069854504 @default.
• W2901363609 cites W2071827110 @default.
• W2901363609 cites W2071839664 @default.
• W2901363609 cites W2078984907 @default.
• W2901363609 cites W2083204774 @default.
• W2901363609 cites W2085706486 @default.
• W2901363609 cites W2086632664 @default.
• W2901363609 cites W2088991430 @default.
• W2901363609 cites W2091300254 @default.
• W2901363609 cites W2112824246 @default.
• W2901363609 cites W2117287657 @default.
• W2901363609 cites W2122531239 @default.
• W2901363609 cites W2138524791 @default.
• W2901363609 cites W2148539027 @default.
• W2901363609 cites W2149497936 @default.
• W2901363609 cites W2150555083 @default.
• W2901363609 cites W2154850432 @default.
• W2901363609 cites W2157312676 @default.
• W2901363609 cites W2163532408 @default.
• W2901363609 cites W2174764226 @default.
• W2901363609 cites W2231655582 @default.
• W2901363609 cites W233025038 @default.
• W2901363609 cites W2344888355 @default.
• W2901363609 cites W2461838734 @default.
• W2901363609 cites W2469436139 @default.
• W2901363609 cites W2514084603 @default.
• W2901363609 cites W2523292039 @default.
• W2901363609 cites W2558055286 @default.
• W2901363609 cites W2606019459 @default.
• W2901363609 cites W2625626526 @default.
• W2901363609 cites W2742708327 @default.
• W2901363609 cites W2794561705 @default.
• W2901363609 cites W324306875 @default.
• W2901363609 cites W4210979710 @default.
• W2901363609 doi "https://doi.org/10.1007/s12031-018-1194-z" @default.
• W2901363609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6344243" @default.
• W2901363609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30471010" @default.

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