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• W2901382801 abstract "Context Sampling in the nonfasted state might result in false-high measurements of plasma chromogranin A (CgA), a key biomarker for patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). Objective To investigate whether intake of a 5-item English breakfast together with tea/coffee (Bfast-T/C) or intake of tea/coffee (T/C) alone relevantly influences postprandial CgA in GEP-NENs and controls. Methods In a randomised, controlled, double crossover study, we investigated in >10-hour overnight fasted individuals the effects of Bfast-T/C vs T/C vs the ongoing fasted state on 180-minute postprandial plasma CgA concentrations (28 patients with GEP-NENs, of those 22 on treatment with long-acting somatostatin analogues (SSA); and 11 controls). Ten participants (8 GEP-NEN, 2 controls) were on treatment with proton pump inhibitors (PPI). Results Intake of Bfast-TC but not T/C alone increased CgA in the pooled cohort, reflecting the situation in screening, from 90 minute [area under the curve (AUC)CgA0-180 minute, ongoing fasted 172.6 ± 4.6 vs T/C 173.3 ± 5.2 vs Bfast-TC 204.2 ± 7.9, P = 0.0002]. Postprandial responses to Bfast-T/C in controls and GEP-NENs were comparable. PPI usage was associated with markedly increased fasted CgA in the pooled cohort (429.3 ± 90.4 vs 91.0 ± 14.7 µg/L; P < 0.0001). AUC CgA 0-180 minute remained higher following Bfast-T/C after exclusion of PPI users (P < 0.05). In GEP-NENs, effects of Bfast-T/C on postprandial CgA raises were more pronounced in patients not treated with SSA. Conclusions Intake of Bfast-T/C, but not T/C alone, increased postprandial CgA in both patients with GEP-NENs and controls up to 34%. Fasted CgA measurements should be sought, if possible, and PPIs paused prior to measurement. ClinicalTrials.gov Identifier: NCT03288402." @default.
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• W2901382801 date "2018-11-15" @default.
• W2901382801 modified "2023-10-17" @default.
• W2901382801 title "Effects of intake of breakfast or caffeine-containing beverages on measurement of circulating chromogranin A in plasma" @default.
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• W2901382801 doi "https://doi.org/10.1002/ygh2.208" @default.
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