Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901383905> ?p ?o ?g. }
- W2901383905 abstract "Tumor necrosis factor (TNF)‑related apoptosis‑inducing ligand (TRAIL) is a member of the TNF superfamily and is an antitumor drug that induces apoptosis in tumor cells with minimal or no effects on normal cells. Here, it is demonstrated that 6‑shogaol (6‑sho), a bioactive component of ginger, exerted anti‑inflammatory and anticancer properties, attenuated tumor cell propagation and induced TRAIL‑mediated cell death in liver cancer cells. The current study identified a potential pathway by revealing that TRAIL and 6‑sho or chloroquine acted together to trigger reactive oxygen species (ROS) production, to upregulate tumor‑suppressor protein 53 (p53) expression and to change the mitochondrial transmembrane potential (MTP). Treatment with N‑acetyl‑L‑cysteine reversed these effects, restoring the MTP and attenuated ROS production and p53 expression. Interestingly, treatment with 6‑sho increased p62 and microtubule‑associated proteins 1A/1B light chain 3B‑II levels, indicating an inhibited autophagy flux. In conclusion, attenuation of 6‑sho‑induced autophagy flux sensitized cells to TRAIL‑induced apoptosis via p53 and ROS, suggesting that the administration of TRAIL in combination with 6‑sho may be a suitable therapeutic method for the treatment of TRAIL‑resistant Huh7 liver cells." @default.
- W2901383905 created "2018-11-29" @default.
- W2901383905 creator A5024073435 @default.
- W2901383905 creator A5048636392 @default.
- W2901383905 date "2018-11-21" @default.
- W2901383905 modified "2023-10-18" @default.
- W2901383905 title "Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS" @default.
- W2901383905 cites W15573899 @default.
- W2901383905 cites W1565351177 @default.
- W2901383905 cites W1970856815 @default.
- W2901383905 cites W1978691010 @default.
- W2901383905 cites W1981714984 @default.
- W2901383905 cites W1991105254 @default.
- W2901383905 cites W1995986855 @default.
- W2901383905 cites W1998068719 @default.
- W2901383905 cites W2000704839 @default.
- W2901383905 cites W2001591494 @default.
- W2901383905 cites W2015772717 @default.
- W2901383905 cites W2022860417 @default.
- W2901383905 cites W2023137748 @default.
- W2901383905 cites W2023961144 @default.
- W2901383905 cites W2025476423 @default.
- W2901383905 cites W2025722611 @default.
- W2901383905 cites W2034071655 @default.
- W2901383905 cites W2034132952 @default.
- W2901383905 cites W2036316753 @default.
- W2901383905 cites W2041618813 @default.
- W2901383905 cites W2042852113 @default.
- W2901383905 cites W2044663539 @default.
- W2901383905 cites W2044883658 @default.
- W2901383905 cites W2049054723 @default.
- W2901383905 cites W2056564326 @default.
- W2901383905 cites W2061576471 @default.
- W2901383905 cites W2067692987 @default.
- W2901383905 cites W2069350665 @default.
- W2901383905 cites W2074273705 @default.
- W2901383905 cites W2076794972 @default.
- W2901383905 cites W2080406700 @default.
- W2901383905 cites W2085062814 @default.
- W2901383905 cites W2089684638 @default.
- W2901383905 cites W2094570524 @default.
- W2901383905 cites W2106255061 @default.
- W2901383905 cites W2106284224 @default.
- W2901383905 cites W2114533170 @default.
- W2901383905 cites W2117476538 @default.
- W2901383905 cites W2138482985 @default.
- W2901383905 cites W2145388691 @default.
- W2901383905 cites W2148572497 @default.
- W2901383905 cites W2265261560 @default.
- W2901383905 cites W2276313065 @default.
- W2901383905 cites W2299525559 @default.
- W2901383905 cites W2396136516 @default.
- W2901383905 cites W2413511575 @default.
- W2901383905 cites W2591840778 @default.
- W2901383905 cites W2757062831 @default.
- W2901383905 cites W2758941402 @default.
- W2901383905 cites W2761840589 @default.
- W2901383905 cites W2767363722 @default.
- W2901383905 cites W4377077044 @default.
- W2901383905 doi "https://doi.org/10.3892/ijmm.2018.3994" @default.
- W2901383905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6317668" @default.
- W2901383905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30483736" @default.
- W2901383905 hasPublicationYear "2018" @default.
- W2901383905 type Work @default.
- W2901383905 sameAs 2901383905 @default.
- W2901383905 citedByCount "16" @default.
- W2901383905 countsByYear W29013839052019 @default.
- W2901383905 countsByYear W29013839052020 @default.
- W2901383905 countsByYear W29013839052021 @default.
- W2901383905 countsByYear W29013839052022 @default.
- W2901383905 countsByYear W29013839052023 @default.
- W2901383905 crossrefType "journal-article" @default.
- W2901383905 hasAuthorship W2901383905A5024073435 @default.
- W2901383905 hasAuthorship W2901383905A5048636392 @default.
- W2901383905 hasBestOaLocation W29013839051 @default.
- W2901383905 hasConcept C104317684 @default.
- W2901383905 hasConcept C121608353 @default.
- W2901383905 hasConcept C127561419 @default.
- W2901383905 hasConcept C17991360 @default.
- W2901383905 hasConcept C185592680 @default.
- W2901383905 hasConcept C190283241 @default.
- W2901383905 hasConcept C203014093 @default.
- W2901383905 hasConcept C203522944 @default.
- W2901383905 hasConcept C2781018059 @default.
- W2901383905 hasConcept C29537977 @default.
- W2901383905 hasConcept C31573885 @default.
- W2901383905 hasConcept C48349386 @default.
- W2901383905 hasConcept C502942594 @default.
- W2901383905 hasConcept C54355233 @default.
- W2901383905 hasConcept C55493867 @default.
- W2901383905 hasConcept C86803240 @default.
- W2901383905 hasConcept C95444343 @default.
- W2901383905 hasConcept C96232424 @default.
- W2901383905 hasConceptScore W2901383905C104317684 @default.
- W2901383905 hasConceptScore W2901383905C121608353 @default.
- W2901383905 hasConceptScore W2901383905C127561419 @default.
- W2901383905 hasConceptScore W2901383905C17991360 @default.
- W2901383905 hasConceptScore W2901383905C185592680 @default.
- W2901383905 hasConceptScore W2901383905C190283241 @default.
- W2901383905 hasConceptScore W2901383905C203014093 @default.