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- W2901396567 endingPage "1968" @default.
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- W2901396567 abstract "Chronic lymphocytic leukemia is associated with a highly heterogeneous disease course in terms of clinical outcomes and responses to chemoimmunotherapy. This heterogeneity is partly due to genetic aberrations identified in chronic lymphocytic leukemia cells such as mutations of TP53 and/or deletions in chromosome 17p [del(17p)], resulting in loss of one TP53 allele. These aberrations are associated with markedly decreased survival and predict impaired response to chemoimmunotherapy thus being among the strongest predictive markers guiding treatment decisions in chronic lymphocytic leukemia. Clinical trials demonstrate the importance of accurately testing for TP53 aberrations [both del(17p) and TP53 mutations] before each line of treatment to allow for appropriate treatment decisions that can optimize patients’ outcomes. The current report reviews the diagnostic methods to detect TP53 disruption better, the role of TP53 aberrations in treatment decisions and current therapies available for patients with chronic lymphocytic leukemia carrying these abnormalities. The standardization in sequencing technologies for accurate identification of TP53 mutations and the importance of continued evaluation of TP53 aberrations throughout initial and subsequent lines of therapy remain unmet clinical needs as new therapeutic alternatives become available." @default.
- W2901396567 created "2018-11-29" @default.
- W2901396567 creator A5015131529 @default.
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- W2901396567 creator A5083128083 @default.
- W2901396567 creator A5090615083 @default.
- W2901396567 date "2018-11-15" @default.
- W2901396567 modified "2023-10-18" @default.
- W2901396567 title "<i>TP53</i> aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics" @default.
- W2901396567 cites W1517918365 @default.
- W2901396567 cites W1966841369 @default.
- W2901396567 cites W1971025765 @default.
- W2901396567 cites W1973388908 @default.
- W2901396567 cites W1980260104 @default.
- W2901396567 cites W1987819921 @default.
- W2901396567 cites W1988436508 @default.
- W2901396567 cites W1998529930 @default.
- W2901396567 cites W2005542290 @default.
- W2901396567 cites W2006384917 @default.
- W2901396567 cites W2008225116 @default.
- W2901396567 cites W2008310071 @default.
- W2901396567 cites W2015299436 @default.
- W2901396567 cites W2015687515 @default.
- W2901396567 cites W2016042196 @default.
- W2901396567 cites W2017418108 @default.
- W2901396567 cites W2020069805 @default.
- W2901396567 cites W2020148863 @default.
- W2901396567 cites W2035783958 @default.
- W2901396567 cites W2037439384 @default.
- W2901396567 cites W2037801945 @default.
- W2901396567 cites W2041925366 @default.
- W2901396567 cites W2043511687 @default.
- W2901396567 cites W2051978340 @default.
- W2901396567 cites W2055611408 @default.
- W2901396567 cites W2055898543 @default.
- W2901396567 cites W2065018248 @default.
- W2901396567 cites W2065377819 @default.
- W2901396567 cites W2066564017 @default.
- W2901396567 cites W2067064694 @default.
- W2901396567 cites W2069401990 @default.
- W2901396567 cites W2071549499 @default.
- W2901396567 cites W2074584895 @default.
- W2901396567 cites W2084831115 @default.
- W2901396567 cites W2084952484 @default.
- W2901396567 cites W2088580309 @default.
- W2901396567 cites W2090147047 @default.
- W2901396567 cites W2091168608 @default.
- W2901396567 cites W2095913486 @default.
- W2901396567 cites W2096036897 @default.
- W2901396567 cites W2102036352 @default.
- W2901396567 cites W2106135268 @default.
- W2901396567 cites W2108206643 @default.
- W2901396567 cites W2109948920 @default.
- W2901396567 cites W2110523744 @default.
- W2901396567 cites W2111893233 @default.
- W2901396567 cites W2113240773 @default.
- W2901396567 cites W2113895281 @default.
- W2901396567 cites W2114391838 @default.
- W2901396567 cites W2118149315 @default.
- W2901396567 cites W2124920464 @default.
- W2901396567 cites W2130484464 @default.
- W2901396567 cites W2131078883 @default.
- W2901396567 cites W2136272158 @default.
- W2901396567 cites W2140606816 @default.
- W2901396567 cites W2142099365 @default.
- W2901396567 cites W2146245932 @default.
- W2901396567 cites W2149515595 @default.
- W2901396567 cites W2157596388 @default.
- W2901396567 cites W2159982252 @default.
- W2901396567 cites W2163923077 @default.
- W2901396567 cites W2167045537 @default.
- W2901396567 cites W2192121806 @default.
- W2901396567 cites W2234243759 @default.
- W2901396567 cites W2266706219 @default.
- W2901396567 cites W2309021002 @default.
- W2901396567 cites W2318933236 @default.
- W2901396567 cites W2319367015 @default.
- W2901396567 cites W2335449177 @default.
- W2901396567 cites W2343910676 @default.
- W2901396567 cites W2369297677 @default.
- W2901396567 cites W2396328865 @default.
- W2901396567 cites W2407857284 @default.
- W2901396567 cites W2408036343 @default.
- W2901396567 cites W2414098354 @default.
- W2901396567 cites W2415930204 @default.
- W2901396567 cites W2417386610 @default.
- W2901396567 cites W2418194135 @default.
- W2901396567 cites W2472035483 @default.
- W2901396567 cites W2510710599 @default.
- W2901396567 cites W2518822109 @default.
- W2901396567 cites W2519500141 @default.
- W2901396567 cites W2529199543 @default.
- W2901396567 cites W2530415869 @default.
- W2901396567 cites W2543345947 @default.