Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901410015> ?p ?o ?g. }
- W2901410015 endingPage "309" @default.
- W2901410015 startingPage "302" @default.
- W2901410015 abstract "Single nucleotide polymorphism (SNP)‐based genetic risk score (GRS) and APOE genotype are both important in risk prediction of Alzheimer's disease (AD); however, the interaction between GRS and APOE has not been extensively investigated. Our objective was to determine whether GRS modifies the APOE effect on AD risk and age at onset (AAO). The study included 774 AD cases and 767 controls of European descent. Population standardized GRS was calculated based on 17 previously implicated AD risk‐associated SNPs. Association was analyzed using logistic regression, Cox proportional hazards model and Kaplan‐Meier curve. We found that GRS was significantly associated with AD risk and the association was stronger among APOE ε4 carriers. Compared to ε4 non‐carriers, the Odds Ratio (OR) for AD was 8.09 (95% Confidence Interval [CI]: 4.98‐13.63) for ε4 carriers with high‐GRS (≥1.5). In contrast, the OR was 2.55 (95% CI: 1.46‐4.49) for ε4 carriers with low‐GRS (<0.6). In conclusion, these results suggest SNP‐based GRS may supplement APOE for better assessment of inherited risk and age of onset of AD." @default.
- W2901410015 created "2018-11-29" @default.
- W2901410015 creator A5012256336 @default.
- W2901410015 creator A5031205173 @default.
- W2901410015 creator A5039786650 @default.
- W2901410015 creator A5057004641 @default.
- W2901410015 creator A5059077734 @default.
- W2901410015 creator A5064981403 @default.
- W2901410015 creator A5085312479 @default.
- W2901410015 creator A5090973353 @default.
- W2901410015 date "2018-12-12" @default.
- W2901410015 modified "2023-10-16" @default.
- W2901410015 title "Genetic risk score modifies the effect ofAPOEon risk and age onset of Alzheimer's disease" @default.
- W2901410015 cites W1570622790 @default.
- W2901410015 cites W1716810435 @default.
- W2901410015 cites W1966378425 @default.
- W2901410015 cites W1966831629 @default.
- W2901410015 cites W1984737558 @default.
- W2901410015 cites W1984941194 @default.
- W2901410015 cites W1997338841 @default.
- W2901410015 cites W2006617902 @default.
- W2901410015 cites W2008352401 @default.
- W2901410015 cites W2037804097 @default.
- W2901410015 cites W2067339842 @default.
- W2901410015 cites W2083320551 @default.
- W2901410015 cites W2102709646 @default.
- W2901410015 cites W2104549677 @default.
- W2901410015 cites W2105773588 @default.
- W2901410015 cites W2115779804 @default.
- W2901410015 cites W2120386191 @default.
- W2901410015 cites W2121820194 @default.
- W2901410015 cites W2128613449 @default.
- W2901410015 cites W2145210308 @default.
- W2901410015 cites W2145807088 @default.
- W2901410015 cites W2148641246 @default.
- W2901410015 cites W2149791927 @default.
- W2901410015 cites W2154034238 @default.
- W2901410015 cites W2157405068 @default.
- W2901410015 cites W2165644824 @default.
- W2901410015 cites W2215553937 @default.
- W2901410015 cites W2302711420 @default.
- W2901410015 cites W2313538805 @default.
- W2901410015 cites W2314378690 @default.
- W2901410015 cites W2537845574 @default.
- W2901410015 cites W2587982675 @default.
- W2901410015 cites W2593642799 @default.
- W2901410015 cites W2600084629 @default.
- W2901410015 cites W2608082925 @default.
- W2901410015 cites W2727579002 @default.
- W2901410015 cites W871399632 @default.
- W2901410015 cites W937788945 @default.
- W2901410015 doi "https://doi.org/10.1111/cge.13479" @default.
- W2901410015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30460685" @default.
- W2901410015 hasPublicationYear "2018" @default.
- W2901410015 type Work @default.
- W2901410015 sameAs 2901410015 @default.
- W2901410015 citedByCount "3" @default.
- W2901410015 countsByYear W29014100152019 @default.
- W2901410015 countsByYear W29014100152020 @default.
- W2901410015 crossrefType "journal-article" @default.
- W2901410015 hasAuthorship W2901410015A5012256336 @default.
- W2901410015 hasAuthorship W2901410015A5031205173 @default.
- W2901410015 hasAuthorship W2901410015A5039786650 @default.
- W2901410015 hasAuthorship W2901410015A5057004641 @default.
- W2901410015 hasAuthorship W2901410015A5059077734 @default.
- W2901410015 hasAuthorship W2901410015A5064981403 @default.
- W2901410015 hasAuthorship W2901410015A5085312479 @default.
- W2901410015 hasAuthorship W2901410015A5090973353 @default.
- W2901410015 hasConcept C104317684 @default.
- W2901410015 hasConcept C126322002 @default.
- W2901410015 hasConcept C135763542 @default.
- W2901410015 hasConcept C139275648 @default.
- W2901410015 hasConcept C143998085 @default.
- W2901410015 hasConcept C146304588 @default.
- W2901410015 hasConcept C151956035 @default.
- W2901410015 hasConcept C153209595 @default.
- W2901410015 hasConcept C156957248 @default.
- W2901410015 hasConcept C2777767895 @default.
- W2901410015 hasConcept C2779134260 @default.
- W2901410015 hasConcept C44249647 @default.
- W2901410015 hasConcept C50382708 @default.
- W2901410015 hasConcept C54355233 @default.
- W2901410015 hasConcept C57089818 @default.
- W2901410015 hasConcept C71924100 @default.
- W2901410015 hasConcept C86803240 @default.
- W2901410015 hasConceptScore W2901410015C104317684 @default.
- W2901410015 hasConceptScore W2901410015C126322002 @default.
- W2901410015 hasConceptScore W2901410015C135763542 @default.
- W2901410015 hasConceptScore W2901410015C139275648 @default.
- W2901410015 hasConceptScore W2901410015C143998085 @default.
- W2901410015 hasConceptScore W2901410015C146304588 @default.
- W2901410015 hasConceptScore W2901410015C151956035 @default.
- W2901410015 hasConceptScore W2901410015C153209595 @default.
- W2901410015 hasConceptScore W2901410015C156957248 @default.
- W2901410015 hasConceptScore W2901410015C2777767895 @default.
- W2901410015 hasConceptScore W2901410015C2779134260 @default.
- W2901410015 hasConceptScore W2901410015C44249647 @default.
- W2901410015 hasConceptScore W2901410015C50382708 @default.