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- W2901410689 abstract "An inducible program of inflammatory gene expression is a hallmark of antimicrobial defenses. Recently, cellular nucleic acid–binding protein (CNBP) was identified as a regulator of nuclear factor-kappaB (NF-κB)–dependent proinflammatory cytokine gene expression. Here, we generated mice lacking CNBP and found that CNBP regulates a very restricted gene signature that includes IL-12β. CNBP resides in the cytosol of macrophages and translocates to the nucleus in response to diverse microbial pathogens and pathogen-derived products. Cnbp-deficient macrophages induced canonical NF-κB/Rel signaling normally but were impaired in their ability to control the activation of c-Rel, a key driver of IL-12β gene transcription. The nuclear translocation and DNA-binding activity of c-Rel required CNBP. Lastly, Cnbp-deficient mice were more susceptible to acute toxoplasmosis associated with reduced production of IL-12β, as well as a reduced T helper type 1 (Th1) cell IFN-γ response essential to controlling parasite replication. Collectively, these findings identify CNBP as important regulator of c-Rel–dependent IL-12β gene transcription and Th1 immunity." @default.
- W2901410689 created "2018-11-29" @default.
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- W2901410689 date "2018-11-15" @default.
- W2901410689 modified "2023-10-17" @default.
- W2901410689 title "CNBP controls IL-12 gene transcription and Th1 immunity" @default.
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- W2901410689 doi "https://doi.org/10.1084/jem.20181031" @default.
- W2901410689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279399" @default.
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