FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901423652> ?p ?o ?g. }

• W2901423652 endingPage "e183927" @default.
• W2901423652 startingPage "e183927" @default.
• W2901423652 abstract "Treatment of patients with infections due to Pseudomonas aeruginosa has been complicated by increased antibiotic resistance rates, which contribute to delayed appropriate treatment and deleterious outcomes.To develop 2 clinical risk scores based on variables available at clinical presentation to estimate the risk of carbapenem resistance (CR) or extensive β-lactam resistance (EBR) among hospitalized, adult patients with P aeruginosa infections.This retrospective cohort study included adult (age, ≥18 years) members of Kaiser Permanente Southern California (KPSC) with a P aeruginosa infection during hospitalization from September 1, 2011, through August 31, 2016, who received antibiotic therapy within 2 days of the culture date. Data were analyzed from July 2, 2017, through August 15, 2018.Demographic, clinical, and laboratory covariates 1 year before the index culture date were evaluated.Pseudomonas aeruginosa was categorized as antibiotic susceptible, CR, or EBR (nonsusceptibility to carbapenems, ceftazidime, and combined piperacillin sodium and tazobactam sodium). Patients were randomly split (1:1) into training and validation data sets. The training data set was used to develop 2 prediction models using high-performance logistic regression with variable selection by Schwarz-Bayesian criterion. The models were translated into risk scores, with risk score points equaling the weighted sums of regression coefficients from the prediction model. The patient's risk was estimated as the inverse logit of the risk score.Of the 7775 patients with 11 502 P aeruginosa infections included in the analysis, most were male (4308 [55.4%]) and non-Hispanic white (3927 [50.5%]). The mean (SD) age was 70.3 (15.5) years. Among 11 502 P aeruginosa infections, 2324 (20.2%) were CR, 9178 (79.8%) were non-CR, 1033 (9.0%) were EBR, and 10 469 were non-EBR (91.0%). The strongest predictors of resistance in the CR and EBR models were history of CR P aeruginosa infection (odds ratios [ORs], 8.80 [95% CI, 6.74-11.49] and 5.04 [95% CI, 3.88-6.54], respectively), tracheostomy (ORs, 3.49 [95% CI, 2.92-4.16] and 3.13 [95% CI, 2.50-3.91], respectively), and carbapenem use in the prior 30 days (ORs, 4.18 [95% CI, 3.29-5.31] and 2.26 [95% CI, 1.74-2.93], respectively). The models for CR and EBR performed well, with areas under the receiver operating characteristics curve of 0.81 or greater for the training and validation data sets.The findings of this study suggest that parsimonious risk scores can aid physicians in appropriate treatment selection during the critical period when P aeruginosa infection is suspected but antibiotic susceptibility results are not yet available." @default.
• W2901423652 created "2018-11-29" @default.
• W2901423652 creator A5009305511 @default.
• W2901423652 creator A5018906764 @default.
• W2901423652 creator A5021589539 @default.
• W2901423652 creator A5032804979 @default.
• W2901423652 creator A5036077150 @default.
• W2901423652 creator A5056408133 @default.
• W2901423652 creator A5059385309 @default.
• W2901423652 creator A5073266750 @default.
• W2901423652 creator A5084249121 @default.
• W2901423652 creator A5086517796 @default.
• W2901423652 date "2018-10-26" @default.
• W2901423652 modified "2023-10-11" @default.
• W2901423652 title "Development and Assessment of Risk Scores for Carbapenem and Extensive β-Lactam Resistance Among Adult Hospitalized Patients With<i>Pseudomonas aeruginosa</i>Infection" @default.
• W2901423652 cites W1966853663 @default.
• W2901423652 cites W1980040599 @default.
• W2901423652 cites W1982939735 @default.
• W2901423652 cites W1984693521 @default.
• W2901423652 cites W1993425222 @default.
• W2901423652 cites W2002773042 @default.
• W2901423652 cites W2027620324 @default.
• W2901423652 cites W2037195555 @default.
• W2901423652 cites W2075287054 @default.
• W2901423652 cites W2077951392 @default.
• W2901423652 cites W2088612865 @default.
• W2901423652 cites W2097293600 @default.
• W2901423652 cites W2102614609 @default.
• W2901423652 cites W2107810227 @default.
• W2901423652 cites W2133644179 @default.
• W2901423652 cites W2148706534 @default.
• W2901423652 cites W2151958462 @default.
• W2901423652 cites W2168175751 @default.
• W2901423652 cites W2189916683 @default.
• W2901423652 cites W2331738366 @default.
• W2901423652 cites W4232568236 @default.
• W2901423652 cites W4249999102 @default.
• W2901423652 cites W91490447 @default.
• W2901423652 doi "https://doi.org/10.1001/jamanetworkopen.2018.3927" @default.
• W2901423652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6324445" @default.
• W2901423652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30646267" @default.
• W2901423652 hasPublicationYear "2018" @default.
• W2901423652 type Work @default.
• W2901423652 sameAs 2901423652 @default.
• W2901423652 citedByCount "16" @default.
• W2901423652 countsByYear W29014236522019 @default.
• W2901423652 countsByYear W29014236522020 @default.
• W2901423652 countsByYear W29014236522021 @default.
• W2901423652 countsByYear W29014236522022 @default.
• W2901423652 countsByYear W29014236522023 @default.
• W2901423652 crossrefType "journal-article" @default.
• W2901423652 hasAuthorship W2901423652A5009305511 @default.
• W2901423652 hasAuthorship W2901423652A5018906764 @default.
• W2901423652 hasAuthorship W2901423652A5021589539 @default.
• W2901423652 hasAuthorship W2901423652A5032804979 @default.
• W2901423652 hasAuthorship W2901423652A5036077150 @default.
• W2901423652 hasAuthorship W2901423652A5056408133 @default.
• W2901423652 hasAuthorship W2901423652A5059385309 @default.
• W2901423652 hasAuthorship W2901423652A5073266750 @default.
• W2901423652 hasAuthorship W2901423652A5084249121 @default.
• W2901423652 hasAuthorship W2901423652A5086517796 @default.
• W2901423652 hasBestOaLocation W29014236521 @default.
• W2901423652 hasConcept C126322002 @default.
• W2901423652 hasConcept C151956035 @default.
• W2901423652 hasConcept C2776685102 @default.
• W2901423652 hasConcept C2777637488 @default.
• W2901423652 hasConcept C2777858937 @default.
• W2901423652 hasConcept C2778193466 @default.
• W2901423652 hasConcept C2778266534 @default.
• W2901423652 hasConcept C501593827 @default.
• W2901423652 hasConcept C523546767 @default.
• W2901423652 hasConcept C54355233 @default.
• W2901423652 hasConcept C71924100 @default.
• W2901423652 hasConcept C86803240 @default.
• W2901423652 hasConcept C89423630 @default.
• W2901423652 hasConceptScore W2901423652C126322002 @default.
• W2901423652 hasConceptScore W2901423652C151956035 @default.
• W2901423652 hasConceptScore W2901423652C2776685102 @default.
• W2901423652 hasConceptScore W2901423652C2777637488 @default.
• W2901423652 hasConceptScore W2901423652C2777858937 @default.
• W2901423652 hasConceptScore W2901423652C2778193466 @default.
• W2901423652 hasConceptScore W2901423652C2778266534 @default.
• W2901423652 hasConceptScore W2901423652C501593827 @default.
• W2901423652 hasConceptScore W2901423652C523546767 @default.
• W2901423652 hasConceptScore W2901423652C54355233 @default.
• W2901423652 hasConceptScore W2901423652C71924100 @default.
• W2901423652 hasConceptScore W2901423652C86803240 @default.
• W2901423652 hasConceptScore W2901423652C89423630 @default.
• W2901423652 hasIssue "6" @default.
• W2901423652 hasLocation W29014236521 @default.
• W2901423652 hasLocation W29014236522 @default.
• W2901423652 hasLocation W29014236523 @default.
• W2901423652 hasLocation W29014236524 @default.
• W2901423652 hasOpenAccess W2901423652 @default.
• W2901423652 hasPrimaryLocation W29014236521 @default.
• W2901423652 hasRelatedWork W2026293122 @default.
• W2901423652 hasRelatedWork W2054393489 @default.
• W2901423652 hasRelatedWork W2134639195 @default.

• next