FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901424823> ?p ?o ?g. }

• W2901424823 endingPage "4021" @default.
• W2901424823 startingPage "3999" @default.
• W2901424823 abstract "Mechanism involved in insulin resistance via accumulation of beta-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease Sima Kianpour Rad,1 Aditya Arya,2–4 Hamed Karimian,2 Priya Madhavan,5 Farzana Rizwan,5 Shajan Koshy,5 Girish Prabhu5 1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Pharmacology and Therapeutics, School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia; 3Department of Pharmacology and Therapeutics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia; 4Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), Bukit Gambir, Gelugor, Pulau Pinang, Malaysia; 5School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia Abstract: The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) has been suggested in several reports. Few findings suggest that T2DM has strong link in the development process of AD, and the complete mechanism is yet to be revealed. Formation of amyloid plaques (APs) and neurofibrillary tangles (NFTs) are two central hallmarks in the AD. APs are the dense composites of β-amyloid protein (Aβ) which accumulates around the nerve cells. Moreover, NFTs are the twisted fibers containing hyperphosphorylated tau proteins present in certain residues of Aβ that build up inside the brain cells. Certain factors contribute to the aetiogenesis of AD by regulating insulin signaling pathway in the brain and accelerating the formation of neurotoxic Aβ and NFTs via various mechanisms, including GSK3β, JNK, CamKII, CDK5, CK1, MARK4, PLK2, Syk, DYRK1A, PPP, and P70S6K. Progression to AD could be influenced by insulin signaling pathway that is affected due to T2DM. Interestingly, NFTs and APs lead to the impairment of several crucial cascades, such as synaptogenesis, neurotrophy, and apoptosis, which are regulated by insulin, cholesterol, and glucose metabolism. The investigation of the molecular cascades through insulin functions in brain contributes to probe and perceive progressions of diabetes to AD. This review elaborates the molecular insights that would help to further understand the potential mechanisms linking T2DM and AD. Keywords: Alzheimer’s disease, type 2 diabetes mellitus, insulin deficiency, insulin signaling pathway, cholesterol" @default.
• W2901424823 created "2018-11-29" @default.
• W2901424823 creator A5014887306 @default.
• W2901424823 creator A5017238840 @default.
• W2901424823 creator A5019325995 @default.
• W2901424823 creator A5030582989 @default.
• W2901424823 creator A5032205770 @default.
• W2901424823 creator A5081956844 @default.
• W2901424823 creator A5089764779 @default.
• W2901424823 date "2018-11-01" @default.
• W2901424823 modified "2023-10-14" @default.
• W2901424823 title "Mechanism involved in insulin resistance via accumulation of &beta;-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer&rsquo;s disease" @default.
• W2901424823 cites W1483825698 @default.
• W2901424823 cites W1508589930 @default.
• W2901424823 cites W1508658753 @default.
• W2901424823 cites W1515328725 @default.
• W2901424823 cites W1552673037 @default.
• W2901424823 cites W1553669285 @default.
• W2901424823 cites W1560839641 @default.
• W2901424823 cites W1561114541 @default.
• W2901424823 cites W1561443084 @default.
• W2901424823 cites W1563116834 @default.
• W2901424823 cites W1569031481 @default.
• W2901424823 cites W1577837690 @default.
• W2901424823 cites W1589427638 @default.
• W2901424823 cites W1600934558 @default.
• W2901424823 cites W1607727630 @default.
• W2901424823 cites W1639168368 @default.
• W2901424823 cites W1743841615 @default.
• W2901424823 cites W1778767804 @default.
• W2901424823 cites W1819107323 @default.
• W2901424823 cites W1819313933 @default.
• W2901424823 cites W1888183027 @default.
• W2901424823 cites W1903012165 @default.
• W2901424823 cites W1950169838 @default.
• W2901424823 cites W1952105398 @default.
• W2901424823 cites W1960647274 @default.
• W2901424823 cites W1963724074 @default.
• W2901424823 cites W1964830067 @default.
• W2901424823 cites W1965284943 @default.
• W2901424823 cites W1965957039 @default.
• W2901424823 cites W1967239279 @default.
• W2901424823 cites W1968009106 @default.
• W2901424823 cites W1968293808 @default.
• W2901424823 cites W1968308838 @default.
• W2901424823 cites W1968531410 @default.
• W2901424823 cites W1969012880 @default.
• W2901424823 cites W1969688059 @default.
• W2901424823 cites W1969713114 @default.
• W2901424823 cites W1972589163 @default.
• W2901424823 cites W1972703677 @default.
• W2901424823 cites W1972907045 @default.
• W2901424823 cites W1974939683 @default.
• W2901424823 cites W1975863794 @default.
• W2901424823 cites W1978999542 @default.
• W2901424823 cites W1979266787 @default.
• W2901424823 cites W1980213797 @default.
• W2901424823 cites W1981219457 @default.
• W2901424823 cites W1982795519 @default.
• W2901424823 cites W1986464708 @default.
• W2901424823 cites W1988332799 @default.
• W2901424823 cites W1989493701 @default.
• W2901424823 cites W1989687285 @default.
• W2901424823 cites W1993553556 @default.
• W2901424823 cites W1993812967 @default.
• W2901424823 cites W1994930233 @default.
• W2901424823 cites W1996660429 @default.
• W2901424823 cites W1997198091 @default.
• W2901424823 cites W1999356704 @default.
• W2901424823 cites W1999445997 @default.
• W2901424823 cites W1999631936 @default.
• W2901424823 cites W1999970418 @default.
• W2901424823 cites W2001489292 @default.
• W2901424823 cites W2001599368 @default.
• W2901424823 cites W2002440118 @default.
• W2901424823 cites W2003454094 @default.
• W2901424823 cites W2004836634 @default.
• W2901424823 cites W2005740454 @default.
• W2901424823 cites W2008271008 @default.
• W2901424823 cites W2011430246 @default.
• W2901424823 cites W2017807856 @default.
• W2901424823 cites W2017958484 @default.
• W2901424823 cites W2018423808 @default.
• W2901424823 cites W2018595649 @default.
• W2901424823 cites W2019047215 @default.
• W2901424823 cites W2019455536 @default.
• W2901424823 cites W2020355217 @default.
• W2901424823 cites W2020771043 @default.
• W2901424823 cites W2022924617 @default.
• W2901424823 cites W2022952278 @default.
• W2901424823 cites W2024977477 @default.
• W2901424823 cites W2027958854 @default.
• W2901424823 cites W2029559333 @default.
• W2901424823 cites W2031615911 @default.
• W2901424823 cites W2032064329 @default.
• W2901424823 cites W2034896813 @default.
• W2901424823 cites W2036011584 @default.
• W2901424823 cites W2036258710 @default.

• next