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• W2901427983 abstract "Osimertinib (AZD9291) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that has been approved for the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). In this study, osimertinib was characterized as a LSD1 inhibitor for the first time with an IC50 of 3.98 ± 0.3 μM and showed LSD1 inhibitory effect at cellular level. These findings provide new molecular skeleton for dual inhibitor for LSD1 and EGFR. Osimertinib could serve as a lead compound for further development for anti-NSCLC drug discovery with dual targeting." @default.
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• W2901427983 date "2019-03-01" @default.
• W2901427983 modified "2023-10-18" @default.
• W2901427983 title "Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor" @default.
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• W2901427983 doi "https://doi.org/10.1016/j.bioorg.2018.11.018" @default.
• W2901427983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30502627" @default.
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