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- W2901428716 endingPage "e0207041" @default.
- W2901428716 startingPage "e0207041" @default.
- W2901428716 abstract "Many pharmaceuticals have negative effects on biota when released into the environment. For example, recent work has shown that the commonly prescribed antidiabetic drug, metformin (N,N-dimethylbiguanide), has endocrine disrupting effects on fish. However, effects of metformin on aquatic primary producers are poorly known. We exposed cultured isolates of a freshwater chlorophyte, Chlorella vulgaris, to a range of metformin concentrations (0-767.9 mg L-1) to test the hypothesis that exposure negatively affects photosynthesis and growth. A cessation of growth, increase in non-photochemical quenching (NPQ, NPQmax), and reduced electron transport rate (ETR) were observed 24 h after exposure to a metformin concentration of 767.8 mg L-1 (4.6 mM). By 48 h, photosynthetic efficiency of photosystem II (Fv/Fm), α, the initial slope of the ETR-irradiance curve, and Ek (minimum irradiance required to saturate photosynthesis) were reduced. At a lower concentration (76.8 mg L-1), negative effects on photosynthesis (increase in NPQ, decrease in ETR) were delayed, occurring between 72 and 96 h. No negative effects on photosynthesis were observed at an exposure concentration of 1.5 mg L-1. It is likely that metformin impairs photosynthesis either through downstream effects from inhibition of complex I of the electron transport chain or via activation of the enzyme, SnRK1 (sucrose non-fermenting-related kinase 1), which acts as a cellular energy regulator in plants and algae and is an ortholog of the mammalian target of metformin, AMPK (5' adenosine monophosphate-activated protein kinase)." @default.
- W2901428716 created "2018-11-29" @default.
- W2901428716 creator A5038828441 @default.
- W2901428716 creator A5066450107 @default.
- W2901428716 creator A5067982780 @default.
- W2901428716 date "2018-11-12" @default.
- W2901428716 modified "2023-10-17" @default.
- W2901428716 title "Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris" @default.
- W2901428716 cites W1645054884 @default.
- W2901428716 cites W1950969465 @default.
- W2901428716 cites W1990805173 @default.
- W2901428716 cites W1992244454 @default.
- W2901428716 cites W1995069275 @default.
- W2901428716 cites W1995089473 @default.
- W2901428716 cites W1996613760 @default.
- W2901428716 cites W1997224005 @default.
- W2901428716 cites W2001678680 @default.
- W2901428716 cites W2002637371 @default.
- W2901428716 cites W2003849142 @default.
- W2901428716 cites W2005333176 @default.
- W2901428716 cites W2005350385 @default.
- W2901428716 cites W2006874383 @default.
- W2901428716 cites W200815906 @default.
- W2901428716 cites W2012442095 @default.
- W2901428716 cites W2014402232 @default.
- W2901428716 cites W2014643645 @default.
- W2901428716 cites W2018370328 @default.
- W2901428716 cites W2022819817 @default.
- W2901428716 cites W2026044281 @default.
- W2901428716 cites W2033623913 @default.
- W2901428716 cites W2034934912 @default.
- W2901428716 cites W2037766564 @default.
- W2901428716 cites W2046190423 @default.
- W2901428716 cites W2047373064 @default.
- W2901428716 cites W2047848415 @default.
- W2901428716 cites W2049796036 @default.
- W2901428716 cites W2053434700 @default.
- W2901428716 cites W2060287786 @default.
- W2901428716 cites W2060582181 @default.
- W2901428716 cites W2065427800 @default.
- W2901428716 cites W2065881882 @default.
- W2901428716 cites W2065931742 @default.
- W2901428716 cites W2069070794 @default.
- W2901428716 cites W2070252553 @default.
- W2901428716 cites W2072982091 @default.
- W2901428716 cites W2074726723 @default.
- W2901428716 cites W2080654617 @default.
- W2901428716 cites W2085199366 @default.
- W2901428716 cites W2085662670 @default.
- W2901428716 cites W2090189626 @default.
- W2901428716 cites W2094514382 @default.
- W2901428716 cites W2101174866 @default.
- W2901428716 cites W2109937180 @default.
- W2901428716 cites W2114825009 @default.
- W2901428716 cites W2115292284 @default.
- W2901428716 cites W2117555911 @default.
- W2901428716 cites W2122475106 @default.
- W2901428716 cites W2128668364 @default.
- W2901428716 cites W2138226825 @default.
- W2901428716 cites W2141778501 @default.
- W2901428716 cites W2143512060 @default.
- W2901428716 cites W2144280397 @default.
- W2901428716 cites W2151693044 @default.
- W2901428716 cites W2152458647 @default.
- W2901428716 cites W2154024784 @default.
- W2901428716 cites W2155185645 @default.
- W2901428716 cites W2161100705 @default.
- W2901428716 cites W2165012926 @default.
- W2901428716 cites W2187328233 @default.
- W2901428716 cites W2210167719 @default.
- W2901428716 cites W2277565015 @default.
- W2901428716 cites W2322297310 @default.
- W2901428716 cites W2488117567 @default.
- W2901428716 cites W2516246423 @default.
- W2901428716 cites W2566779945 @default.
- W2901428716 cites W2587657690 @default.
- W2901428716 cites W2727420541 @default.
- W2901428716 cites W2742200852 @default.
- W2901428716 cites W2747084217 @default.
- W2901428716 cites W2768820759 @default.
- W2901428716 cites W2783389295 @default.
- W2901428716 cites W2798058964 @default.
- W2901428716 cites W4237511945 @default.
- W2901428716 cites W4241523079 @default.
- W2901428716 cites W569171720 @default.
- W2901428716 doi "https://doi.org/10.1371/journal.pone.0207041" @default.
- W2901428716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6231646" @default.
- W2901428716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30419044" @default.
- W2901428716 hasPublicationYear "2018" @default.
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