Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901434088> ?p ?o ?g. }
- W2901434088 abstract "Traditional risk factors are insufficient to explain all cases of coronary artery disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products (AGEs) and their receptors may play important roles in the development and progression of CAD. Hyperglycemia is the hallmark feature of DM. An increase in the incidence of both micro-and macrovascular complications of diabetes has been observed with increased duration of hyperglycemia. This association persists even after glycemic control has been achieved, suggesting an innate mechanism of “metabolic memory.” AGEs are glycated proteins that may serve as mediators of metabolic memory due to their increased production in the setting of hyperglycemia and generally slow turnover. Elevated AGE levels can lead to abnormal cross linking of extracellular and intracellular proteins disrupting their normal structure and function. Furthermore, activation of AGE receptors can induce complex signaling pathways leading to increased inflammation, oxidative stress, enhanced calcium deposition, and increased vascular smooth muscle apoptosis, contributing to the development of atherosclerosis. Through these mechanisms, AGEs may be important mediators of the development of CAD. However, clinical studies regarding the role of AGEs and their receptors in advancing CAD are limited, with contradictory results. AGEs and their receptors may be useful biomarkers for the presence and severity of CAD. Further studies are needed to evaluate the utility of circulating and tissue AGE levels in identifying asymptomatic patients at risk for CAD or to identify patients who may benefit from invasive intervention." @default.
- W2901434088 created "2018-11-29" @default.
- W2901434088 creator A5032444889 @default.
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- W2901434088 creator A5072047115 @default.
- W2901434088 creator A5073499390 @default.
- W2901434088 creator A5086700914 @default.
- W2901434088 date "2018-11-23" @default.
- W2901434088 modified "2023-10-16" @default.
- W2901434088 title "The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: a review" @default.
- W2901434088 cites W1503258737 @default.
- W2901434088 cites W1510575902 @default.
- W2901434088 cites W1526927233 @default.
- W2901434088 cites W1568529372 @default.
- W2901434088 cites W1579325356 @default.
- W2901434088 cites W1594856996 @default.
- W2901434088 cites W1694482919 @default.
- W2901434088 cites W172609984 @default.
- W2901434088 cites W1809577636 @default.
- W2901434088 cites W1964095037 @default.
- W2901434088 cites W1965220977 @default.
- W2901434088 cites W1965286369 @default.
- W2901434088 cites W1966234811 @default.
- W2901434088 cites W1967458701 @default.
- W2901434088 cites W1967559826 @default.
- W2901434088 cites W1973852753 @default.
- W2901434088 cites W1976474010 @default.
- W2901434088 cites W1978611180 @default.
- W2901434088 cites W1979869319 @default.
- W2901434088 cites W1980128710 @default.
- W2901434088 cites W1981965866 @default.
- W2901434088 cites W1982711845 @default.
- W2901434088 cites W1984513597 @default.
- W2901434088 cites W1985236743 @default.
- W2901434088 cites W1985775184 @default.
- W2901434088 cites W1986059252 @default.
- W2901434088 cites W1987934876 @default.
- W2901434088 cites W1989522067 @default.
- W2901434088 cites W1990313130 @default.
- W2901434088 cites W1990675333 @default.
- W2901434088 cites W1991083828 @default.
- W2901434088 cites W1997453627 @default.
- W2901434088 cites W1998614770 @default.
- W2901434088 cites W1999142734 @default.
- W2901434088 cites W1999908383 @default.
- W2901434088 cites W2001642524 @default.
- W2901434088 cites W2005152294 @default.
- W2901434088 cites W2010202880 @default.
- W2901434088 cites W2011594751 @default.
- W2901434088 cites W2012070284 @default.
- W2901434088 cites W2012772537 @default.
- W2901434088 cites W2014684213 @default.
- W2901434088 cites W2019226618 @default.
- W2901434088 cites W2020075925 @default.
- W2901434088 cites W2020407562 @default.
- W2901434088 cites W2020411521 @default.
- W2901434088 cites W2021111727 @default.
- W2901434088 cites W2021820449 @default.
- W2901434088 cites W2022575740 @default.
- W2901434088 cites W2029388843 @default.
- W2901434088 cites W2030022427 @default.
- W2901434088 cites W2031314136 @default.
- W2901434088 cites W2032789741 @default.
- W2901434088 cites W2035759625 @default.
- W2901434088 cites W2037220544 @default.
- W2901434088 cites W2037940400 @default.
- W2901434088 cites W2038528673 @default.
- W2901434088 cites W2040114993 @default.
- W2901434088 cites W2040408902 @default.
- W2901434088 cites W2041168208 @default.
- W2901434088 cites W2043856487 @default.
- W2901434088 cites W2046488831 @default.
- W2901434088 cites W2047451855 @default.
- W2901434088 cites W2053365438 @default.
- W2901434088 cites W2054470952 @default.
- W2901434088 cites W2055499273 @default.
- W2901434088 cites W2055827648 @default.
- W2901434088 cites W2056138839 @default.
- W2901434088 cites W2056248104 @default.
- W2901434088 cites W2057961754 @default.
- W2901434088 cites W2058786800 @default.
- W2901434088 cites W2063165518 @default.
- W2901434088 cites W2066778628 @default.
- W2901434088 cites W2068174711 @default.
- W2901434088 cites W2068900191 @default.
- W2901434088 cites W2069208386 @default.
- W2901434088 cites W2072194907 @default.
- W2901434088 cites W2072265321 @default.
- W2901434088 cites W2074756738 @default.
- W2901434088 cites W2074794423 @default.
- W2901434088 cites W2077088113 @default.
- W2901434088 cites W2081240175 @default.
- W2901434088 cites W2081249375 @default.
- W2901434088 cites W2081256014 @default.
- W2901434088 cites W2081901990 @default.
- W2901434088 cites W2082487229 @default.
- W2901434088 cites W2086204200 @default.
- W2901434088 cites W2086327676 @default.
- W2901434088 cites W2094946113 @default.
- W2901434088 cites W2096857883 @default.