Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901434239> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2901434239 endingPage "3676" @default.
- W2901434239 startingPage "3669" @default.
- W2901434239 abstract "We have described a novel cytokine encoded by a gene called Meteorin-like (Metrnl). Metrnl is a small (∼28 kDa) secreted protein expressed by activated macrophages and barrier tissues (mucosa and skin). Metrnl production by bone marrow macrophages is induced by several cytokines including TNF-α, IL-17α, IL-12, and IL-4 and inhibited by IFN-γ and TGF-β. Metrnl expression in macrophages is also induced by LPS, and its levels in circulation are associated with inflammatory responses in vivo. Furthermore, Metrnl regulates the production of several cytokines and chemokines in macrophages. We have produced a Metrnl-/- mouse, which is viable and shows normal development. However, it exhibits dysregulated cytokine production, alterations in IgG production, and is highly susceptible to LPS in a sepsis model. Furthermore, older Metrnl-/- mice develop inflammatory lesions, suggesting that Metrnl participates in the control of inflammatory responses. Taken together, these observations indicate that Metrnl encodes a novel immunoregulatory cytokine associated with inflammatory responses that we have designated Meteorin-β." @default.
- W2901434239 created "2018-11-29" @default.
- W2901434239 creator A5002574235 @default.
- W2901434239 creator A5008853053 @default.
- W2901434239 creator A5021383631 @default.
- W2901434239 creator A5071721751 @default.
- W2901434239 creator A5073606229 @default.
- W2901434239 creator A5075804536 @default.
- W2901434239 creator A5084720476 @default.
- W2901434239 creator A5090812124 @default.
- W2901434239 date "2018-12-15" @default.
- W2901434239 modified "2023-10-18" @default.
- W2901434239 title "Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation" @default.
- W2901434239 cites W1571105297 @default.
- W2901434239 cites W1575771647 @default.
- W2901434239 cites W1671840178 @default.
- W2901434239 cites W1951130782 @default.
- W2901434239 cites W2016251016 @default.
- W2901434239 cites W2046422749 @default.
- W2901434239 cites W2048368626 @default.
- W2901434239 cites W2052834898 @default.
- W2901434239 cites W2086562954 @default.
- W2901434239 cites W2089573422 @default.
- W2901434239 cites W2100901040 @default.
- W2901434239 cites W2105960411 @default.
- W2901434239 cites W2121191508 @default.
- W2901434239 cites W2162166699 @default.
- W2901434239 cites W2308557365 @default.
- W2901434239 cites W2308792635 @default.
- W2901434239 cites W2317947758 @default.
- W2901434239 cites W2472029233 @default.
- W2901434239 cites W2485577998 @default.
- W2901434239 cites W2513799135 @default.
- W2901434239 cites W2523212458 @default.
- W2901434239 cites W2528918974 @default.
- W2901434239 cites W2594874588 @default.
- W2901434239 cites W2763948002 @default.
- W2901434239 cites W4301684008 @default.
- W2901434239 doi "https://doi.org/10.4049/jimmunol.1800435" @default.
- W2901434239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6394858" @default.
- W2901434239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30464051" @default.
- W2901434239 hasPublicationYear "2018" @default.
- W2901434239 type Work @default.
- W2901434239 sameAs 2901434239 @default.
- W2901434239 citedByCount "58" @default.
- W2901434239 countsByYear W29014342392019 @default.
- W2901434239 countsByYear W29014342392020 @default.
- W2901434239 countsByYear W29014342392021 @default.
- W2901434239 countsByYear W29014342392022 @default.
- W2901434239 countsByYear W29014342392023 @default.
- W2901434239 crossrefType "journal-article" @default.
- W2901434239 hasAuthorship W2901434239A5002574235 @default.
- W2901434239 hasAuthorship W2901434239A5008853053 @default.
- W2901434239 hasAuthorship W2901434239A5021383631 @default.
- W2901434239 hasAuthorship W2901434239A5071721751 @default.
- W2901434239 hasAuthorship W2901434239A5073606229 @default.
- W2901434239 hasAuthorship W2901434239A5075804536 @default.
- W2901434239 hasAuthorship W2901434239A5084720476 @default.
- W2901434239 hasAuthorship W2901434239A5090812124 @default.
- W2901434239 hasBestOaLocation W29014342391 @default.
- W2901434239 hasConcept C13373296 @default.
- W2901434239 hasConcept C203014093 @default.
- W2901434239 hasConcept C2776914184 @default.
- W2901434239 hasConcept C2778690821 @default.
- W2901434239 hasConcept C86803240 @default.
- W2901434239 hasConcept C95444343 @default.
- W2901434239 hasConceptScore W2901434239C13373296 @default.
- W2901434239 hasConceptScore W2901434239C203014093 @default.
- W2901434239 hasConceptScore W2901434239C2776914184 @default.
- W2901434239 hasConceptScore W2901434239C2778690821 @default.
- W2901434239 hasConceptScore W2901434239C86803240 @default.
- W2901434239 hasConceptScore W2901434239C95444343 @default.
- W2901434239 hasIssue "12" @default.
- W2901434239 hasLocation W29014342391 @default.
- W2901434239 hasLocation W29014342392 @default.
- W2901434239 hasLocation W29014342393 @default.
- W2901434239 hasLocation W29014342394 @default.
- W2901434239 hasLocation W29014342395 @default.
- W2901434239 hasOpenAccess W2901434239 @default.
- W2901434239 hasPrimaryLocation W29014342391 @default.
- W2901434239 hasRelatedWork W1820586630 @default.
- W2901434239 hasRelatedWork W1862781172 @default.
- W2901434239 hasRelatedWork W1967052290 @default.
- W2901434239 hasRelatedWork W2019340566 @default.
- W2901434239 hasRelatedWork W2031084334 @default.
- W2901434239 hasRelatedWork W2085121068 @default.
- W2901434239 hasRelatedWork W2196456463 @default.
- W2901434239 hasRelatedWork W3130459936 @default.
- W2901434239 hasRelatedWork W4206479428 @default.
- W2901434239 hasRelatedWork W4211126259 @default.
- W2901434239 hasVolume "201" @default.
- W2901434239 isParatext "false" @default.
- W2901434239 isRetracted "false" @default.
- W2901434239 magId "2901434239" @default.
- W2901434239 workType "article" @default.