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- W2901436701 abstract "Abstract Theileria annulata is a protozoan parasite that infects and transforms bovine macrophages causing a myeloid-leukaemia-like disease called tropical theileriosis. TGF-β2 is highly expressed in many cancer cells and is significantly increased in Theileria -transformed macrophages, as are levels of Reactive Oxygen Species (ROS), notably H 2 O 2 . Here, we describe the interplay between TGF-β2 and ROS in cellular transformation. We show that TGF-β2 drives expression of catalase to reduce the amount of H 2 O 2 produced by T. annulata -transformed bovine macrophages, as well as by human lung (A549) and colon cancer (HT-29) cell lines. Theileria -transformed macrophages attenuated for dissemination express less catalase and produce more H 2 O 2 , but regain both virulent migratory and matrigel traversal phenotypes when stimulated with TGF-β2, or catalase that reduce H 2 O 2 output. Increased H 2 O 2 output therefore, underpins the aggressive dissemination phenotype of diverse tumour cell types, but in contrast, too much H 2 O 2 can dampen dissemination." @default.
- W2901436701 created "2018-11-29" @default.
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- W2901436701 date "2018-11-14" @default.
- W2901436701 modified "2023-10-01" @default.
- W2901436701 title "TGF-β2, catalase activity, H2O2 output and metastatic potential of diverse types of tumour" @default.
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- W2901436701 doi "https://doi.org/10.1101/467191" @default.
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