FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901437744> ?p ?o ?g. }

• W2901437744 abstract "An autoimmune-mediated process in the pathophysiology of narcolepsy type 1 (NT1) is highly suspicious, if this pathomechanism is transferable to other types of central disorders of hypersomnolence (CDH), is still controversial. The association of NT1 with HLA class II system implicates a T-cell-mediated autoimmunity, in which helper CD4+ T-cells and cytotoxic CD8+ T-cells may be pathogenic. This study aimed to identify specific immune profiles in peripheral blood (PB) and cerebrospinal fluid (CSF) in different types of CDH. Forty-three people with polysomnographically confirmed CDH (24 idiopathic hypersomnia [IH], 12 NT1, and 7 NT2) were compared with 24 healthy controls (HC). PB and CSF were analyzed with multiparameter flow cytometry to distinguish between subclasses of peripheral and intrathecal immune cells and specific surface markers of T-cells. The overall proportion of helper CD4+ T-cells and cytotoxic CD8+ T-cells in PB and CSF did not differ between the patients and HC. Activated HLA-DR+ CD4+ T-cells and HLA-DR+ CD8+ T-cells in PB and CSF both in NT1, NT2 and IH were significantly increased compared with HC. A significant correlation of HLA-DR+ CD4+- and HLA-DR+ CD8+ T-cells with higher amounts of excessive daytime sleepiness was found in the NT1 and IH groups, indicating an association of activated T-cells in the central nervous system with an increase in sleepiness. These findings provide further evidence of a T-cell-mediated autoimmunity not only in NT1, but also in NT2 and IH. Moreover, the identification of activated cytotoxic CD8+ T-cells further supports the evidence of T-cell-mediated neuronal damage, which has previously been suggested in NT1." @default.
• W2901437744 created "2018-11-29" @default.
• W2901437744 creator A5018947064 @default.
• W2901437744 creator A5029679895 @default.
• W2901437744 creator A5034872348 @default.
• W2901437744 creator A5061814062 @default.
• W2901437744 creator A5064857246 @default.
• W2901437744 creator A5079544483 @default.
• W2901437744 creator A5088683724 @default.
• W2901437744 date "2018-11-16" @default.
• W2901437744 modified "2023-10-16" @default.
• W2901437744 title "Specific T-cell activation in peripheral blood and cerebrospinal fluid in central disorders of hypersomnolence" @default.
• W2901437744 cites W136165923 @default.
• W2901437744 cites W1786269182 @default.
• W2901437744 cites W1912544112 @default.
• W2901437744 cites W1965784748 @default.
• W2901437744 cites W1968973186 @default.
• W2901437744 cites W1972093420 @default.
• W2901437744 cites W1999024666 @default.
• W2901437744 cites W2000915936 @default.
• W2901437744 cites W2010003461 @default.
• W2901437744 cites W2014720726 @default.
• W2901437744 cites W2018894105 @default.
• W2901437744 cites W2026937220 @default.
• W2901437744 cites W2031576959 @default.
• W2901437744 cites W2036443117 @default.
• W2901437744 cites W2037250847 @default.
• W2901437744 cites W2043438394 @default.
• W2901437744 cites W2053002029 @default.
• W2901437744 cites W2053278781 @default.
• W2901437744 cites W2068064380 @default.
• W2901437744 cites W2079912182 @default.
• W2901437744 cites W2126113358 @default.
• W2901437744 cites W2128948123 @default.
• W2901437744 cites W2133096503 @default.
• W2901437744 cites W2135413406 @default.
• W2901437744 cites W2138900023 @default.
• W2901437744 cites W2152161319 @default.
• W2901437744 cites W2154410506 @default.
• W2901437744 cites W2315760170 @default.
• W2901437744 cites W2415043630 @default.
• W2901437744 cites W2519953634 @default.
• W2901437744 cites W2550663280 @default.
• W2901437744 cites W2576654415 @default.
• W2901437744 cites W2593976315 @default.
• W2901437744 cites W2782542730 @default.
• W2901437744 cites W2890646296 @default.
• W2901437744 cites W4249811109 @default.
• W2901437744 cites W54343044 @default.
• W2901437744 cites W92986853 @default.
• W2901437744 doi "https://doi.org/10.1093/sleep/zsy223" @default.
• W2901437744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30445542" @default.
• W2901437744 hasPublicationYear "2018" @default.
• W2901437744 type Work @default.
• W2901437744 sameAs 2901437744 @default.
• W2901437744 citedByCount "13" @default.
• W2901437744 countsByYear W29014377442019 @default.
• W2901437744 countsByYear W29014377442020 @default.
• W2901437744 countsByYear W29014377442021 @default.
• W2901437744 countsByYear W29014377442022 @default.
• W2901437744 countsByYear W29014377442023 @default.
• W2901437744 crossrefType "journal-article" @default.
• W2901437744 hasAuthorship W2901437744A5018947064 @default.
• W2901437744 hasAuthorship W2901437744A5029679895 @default.
• W2901437744 hasAuthorship W2901437744A5034872348 @default.
• W2901437744 hasAuthorship W2901437744A5061814062 @default.
• W2901437744 hasAuthorship W2901437744A5064857246 @default.
• W2901437744 hasAuthorship W2901437744A5079544483 @default.
• W2901437744 hasAuthorship W2901437744A5088683724 @default.
• W2901437744 hasBestOaLocation W29014377441 @default.
• W2901437744 hasConcept C118552586 @default.
• W2901437744 hasConcept C126322002 @default.
• W2901437744 hasConcept C134018914 @default.
• W2901437744 hasConcept C154317977 @default.
• W2901437744 hasConcept C16568411 @default.
• W2901437744 hasConcept C167672396 @default.
• W2901437744 hasConcept C202751555 @default.
• W2901437744 hasConcept C203014093 @default.
• W2901437744 hasConcept C2776090121 @default.
• W2901437744 hasConcept C2779494582 @default.
• W2901437744 hasConcept C2779651940 @default.
• W2901437744 hasConcept C2780130043 @default.
• W2901437744 hasConcept C553184892 @default.
• W2901437744 hasConcept C55493867 @default.
• W2901437744 hasConcept C71924100 @default.
• W2901437744 hasConcept C86803240 @default.
• W2901437744 hasConcept C8891405 @default.
• W2901437744 hasConceptScore W2901437744C118552586 @default.
• W2901437744 hasConceptScore W2901437744C126322002 @default.
• W2901437744 hasConceptScore W2901437744C134018914 @default.
• W2901437744 hasConceptScore W2901437744C154317977 @default.
• W2901437744 hasConceptScore W2901437744C16568411 @default.
• W2901437744 hasConceptScore W2901437744C167672396 @default.
• W2901437744 hasConceptScore W2901437744C202751555 @default.
• W2901437744 hasConceptScore W2901437744C203014093 @default.
• W2901437744 hasConceptScore W2901437744C2776090121 @default.
• W2901437744 hasConceptScore W2901437744C2779494582 @default.
• W2901437744 hasConceptScore W2901437744C2779651940 @default.
• W2901437744 hasConceptScore W2901437744C2780130043 @default.
• W2901437744 hasConceptScore W2901437744C553184892 @default.

• next