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• W290143854 abstract "A 51-year old smoker developed over 10 months severe ataxia, with dysarthria, clumsiness and vertical oscillopsia. Clinical examination showed a severe pan cerebellar syndrome. Eye-movement abnormalities were as follows: frequent square-wave jerks, gaze evoked nystagmus with rebound, primary position downbeat nystagmus, and virtual absence of smooth pursuit, VOR suppression and OKN. Saccades were hypermetric in all directions but of normal velocity. During horizontal (left or right) saccades there was nearly always a prominent downward conjugate deviation of the eyes, which we will call saccadic downpulsion. In addition, there was left lateropulsion of vertical saccades. MRI was normal but CSF examination showed a lymphocytic pleiocytosis (36 × 106 cells/L) and presence of oligoclonal bands. Although investigations for malignancy were negative, it is likely his cerebellar syndrome had a paraneoplastic aetiology. We propose that the saccadic downpulsion, lateropulsion and dysmetria resulted from dysfunction of the fastigial nucleus and/or oculomotor vermis." @default.
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• W290143854 date "1994-01-01" @default.
• W290143854 modified "2023-09-25" @default.
• W290143854 title "Saccadic Downpulsion in a Patient with Cerebellar Disease" @default.
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• W290143854 doi "https://doi.org/10.1016/b978-0-444-81808-9.50026-3" @default.
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