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- W2901442901 endingPage "150" @default.
- W2901442901 startingPage "150" @default.
- W2901442901 abstract "In hepatocytes and alcohol-metabolizing cultured cells, Golgi undergoes ethanol (EtOH)-induced disorganization. Perinuclear and organized Golgi is important in liver homeostasis, but how the Golgi remains intact is unknown. Work from our laboratories showed that EtOH-altered cellular function could be reversed after alcohol removal; we wanted to determine whether this recovery would apply to Golgi. We used alcohol-metabolizing HepG2 (VA-13) cells (cultured with or without EtOH for 72 h) and rat hepatocytes (control and EtOH-fed (Lieber–DeCarli diet)). For recovery, EtOH was removed and replenished with control medium (48 h for VA-13 cells) or control diet (10 days for rats). Results: EtOH-induced Golgi disassembly was associated with de-dimerization of the largest Golgi matrix protein giantin, along with impaired transport of selected hepatic proteins. After recovery from EtOH, Golgi regained their compact structure, and alterations in giantin and protein transport were restored. In VA-13 cells, when we knocked down giantin, Rab6a GTPase or non-muscle myosin IIB, minimal changes were observed in control conditions, but post-EtOH recovery was impaired. Conclusions: These data provide a link between Golgi organization and plasma membrane protein expression and identify several proteins whose expression is important to maintain Golgi structure during the recovery phase after EtOH administration." @default.
- W2901442901 created "2018-11-29" @default.
- W2901442901 creator A5022129146 @default.
- W2901442901 creator A5030688130 @default.
- W2901442901 creator A5045221188 @default.
- W2901442901 creator A5088616838 @default.
- W2901442901 date "2018-11-16" @default.
- W2901442901 modified "2023-09-28" @default.
- W2901442901 title "Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells" @default.
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- W2901442901 doi "https://doi.org/10.3390/biom8040150" @default.
- W2901442901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6316505" @default.
- W2901442901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30453527" @default.
- W2901442901 hasPublicationYear "2018" @default.
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