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- W2901445745 abstract "For a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, inducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis of inflammatory bowel disease (IBD) and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD." @default.
- W2901445745 created "2018-11-29" @default.
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- W2901445745 date "2018-11-26" @default.
- W2901445745 modified "2023-10-14" @default.
- W2901445745 title "Necroptosis in inflammatory bowel disease and other intestinal diseases" @default.
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- W2901445745 doi "https://doi.org/10.12998/wjcc.v6.i14.745" @default.
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