Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901451050> ?p ?o ?g. }
- W2901451050 endingPage "265" @default.
- W2901451050 startingPage "257" @default.
- W2901451050 abstract "Cell-based therapies using mesenchymal stem/stromal cells (MSCs) have been extensively investigated both in preclinical and clinical settings. Because of their multipotency, MSCs have initially been expected to regenerate tissues by differentiating into native tissue cells. However, accumulating evidence suggests that the observed clinical benefits are largely from the trophic effects of MSCs. In pilot studies, systemic infusion of MSCs has been shown to clinically improve patients with osteogenesis imperfecta and hypophosphatasia even though donor cell engraftment was minimal, suggesting that the trophic effects of MSCs likely play a critical role in the treatment of these pediatric orthopedic diseases. Interestingly, genomic and proteomic analyses demonstrate variance in trophic activities among MSCs from different sources and donors, suggesting that the clinical outcomes could be dependent on the selection of therapeutic MSCs. The purpose of this review is to provide current information regarding MSCs that involve their therapeutic effects and review the clinical outcomes of MSC therapy in pediatric orthopedic diseases. In addition, the potential of cell-free therapy using extracellular vesicles released by MSCs is discussed. Understanding the mechanisms underlying MSC therapeutic actions is critical to selecting therapeutic MSCs for infusion, which will increase the efficacy and consistency of MSC therapy." @default.
- W2901451050 created "2018-11-29" @default.
- W2901451050 creator A5007396780 @default.
- W2901451050 creator A5026202903 @default.
- W2901451050 creator A5033580215 @default.
- W2901451050 date "2019-12-01" @default.
- W2901451050 modified "2023-09-23" @default.
- W2901451050 title "Use of Mesenchymal Stem/Stromal Cells for Pediatric Orthopedic Applications" @default.
- W2901451050 cites W1534465875 @default.
- W2901451050 cites W1534731743 @default.
- W2901451050 cites W1561427403 @default.
- W2901451050 cites W1804670053 @default.
- W2901451050 cites W1925491838 @default.
- W2901451050 cites W1967241081 @default.
- W2901451050 cites W1969832663 @default.
- W2901451050 cites W1971218073 @default.
- W2901451050 cites W1978035979 @default.
- W2901451050 cites W1979388177 @default.
- W2901451050 cites W1980427717 @default.
- W2901451050 cites W1982408656 @default.
- W2901451050 cites W1987174149 @default.
- W2901451050 cites W1988489929 @default.
- W2901451050 cites W1988830115 @default.
- W2901451050 cites W198903736 @default.
- W2901451050 cites W1990808682 @default.
- W2901451050 cites W1991328368 @default.
- W2901451050 cites W1992786647 @default.
- W2901451050 cites W1994586809 @default.
- W2901451050 cites W1994869109 @default.
- W2901451050 cites W1994911597 @default.
- W2901451050 cites W1998650056 @default.
- W2901451050 cites W2000097208 @default.
- W2901451050 cites W2004862098 @default.
- W2901451050 cites W2005962589 @default.
- W2901451050 cites W2010767161 @default.
- W2901451050 cites W2013921793 @default.
- W2901451050 cites W2015055389 @default.
- W2901451050 cites W2018258390 @default.
- W2901451050 cites W2021164682 @default.
- W2901451050 cites W2022322309 @default.
- W2901451050 cites W2022346732 @default.
- W2901451050 cites W2025371271 @default.
- W2901451050 cites W2025803508 @default.
- W2901451050 cites W2027284829 @default.
- W2901451050 cites W2029025070 @default.
- W2901451050 cites W2035176325 @default.
- W2901451050 cites W2037536118 @default.
- W2901451050 cites W2038169922 @default.
- W2901451050 cites W2038919465 @default.
- W2901451050 cites W2039000484 @default.
- W2901451050 cites W2039833863 @default.
- W2901451050 cites W2042659550 @default.
- W2901451050 cites W2042977564 @default.
- W2901451050 cites W2043060398 @default.
- W2901451050 cites W2045571983 @default.
- W2901451050 cites W2049446122 @default.
- W2901451050 cites W2051893135 @default.
- W2901451050 cites W2054099365 @default.
- W2901451050 cites W2061981400 @default.
- W2901451050 cites W2062011959 @default.
- W2901451050 cites W2064856062 @default.
- W2901451050 cites W2064931558 @default.
- W2901451050 cites W2065091374 @default.
- W2901451050 cites W2068102253 @default.
- W2901451050 cites W2071668213 @default.
- W2901451050 cites W2073012898 @default.
- W2901451050 cites W2074786467 @default.
- W2901451050 cites W2074835951 @default.
- W2901451050 cites W2077435353 @default.
- W2901451050 cites W2077510301 @default.
- W2901451050 cites W2082460055 @default.
- W2901451050 cites W2085163273 @default.
- W2901451050 cites W2085959104 @default.
- W2901451050 cites W2089028322 @default.
- W2901451050 cites W2089442121 @default.
- W2901451050 cites W2089963492 @default.
- W2901451050 cites W2091610929 @default.
- W2901451050 cites W2092810335 @default.
- W2901451050 cites W2093583687 @default.
- W2901451050 cites W2095729826 @default.
- W2901451050 cites W2105151699 @default.
- W2901451050 cites W2107503723 @default.
- W2901451050 cites W2113040555 @default.
- W2901451050 cites W2113854724 @default.
- W2901451050 cites W2115950608 @default.
- W2901451050 cites W2116259052 @default.
- W2901451050 cites W2119722987 @default.
- W2901451050 cites W2127300454 @default.
- W2901451050 cites W2131074202 @default.
- W2901451050 cites W2138946470 @default.
- W2901451050 cites W2141225628 @default.
- W2901451050 cites W2144268541 @default.
- W2901451050 cites W2150512825 @default.
- W2901451050 cites W2152451347 @default.
- W2901451050 cites W2158205281 @default.
- W2901451050 cites W2158780936 @default.
- W2901451050 cites W2159616756 @default.
- W2901451050 cites W2159999899 @default.