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- W2901470050 abstract "Abstract Maxing Ganshi Decoction (MXGSD) is used widely for asthma over thousands of years, but its underlying pharmacological mechanisms remain unclear. In this study, systematic and comprehensive network pharmacology was utilized for the first time to reveal the potential pharmacological mechanisms of MXGSD on asthma. Specifically, we collected 141 bioactive components from the 600 components in MXGSD, which shared 52 targets common to asthma-related ones. In-depth network analysis of these 52 common targets indicated that asthma might be a manifestation of systemic neuro-immuno-inflammatory dysfunction in the respiratory system, and MXGSD could treat asthma through relieving airway inflammation, improving airway remodeling, and increasing drug responsiveness. After further cluster and enrichment analysis of the protein-protein interaction network of MXGSD bioactive component targets and asthma-related targets, we found that the neurotrophin signaling pathway, estrogen signaling pathway, PI3K-Akt signaling pathway, and ErbB signaling pathway might serve as the key points and principal pathways of MXGSD gene therapy for asthma from a systemic and holistic perspective, and also provides a novel idea for the development of new drugs for asthma." @default.
- W2901470050 created "2018-11-29" @default.
- W2901470050 creator A5009469965 @default.
- W2901470050 creator A5021749487 @default.
- W2901470050 creator A5044359398 @default.
- W2901470050 creator A5074959373 @default.
- W2901470050 date "2018-11-26" @default.
- W2901470050 modified "2023-10-14" @default.
- W2901470050 title "Uncovering the mechanism of Maxing Ganshi Decoction on asthma from a systematic perspective: A network pharmacology study" @default.
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- W2901470050 doi "https://doi.org/10.1038/s41598-018-35791-9" @default.
- W2901470050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6255815" @default.
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- W2901470050 hasPublicationYear "2018" @default.
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