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- W2901472882 abstract "New insights into IgG4-related disease (IgG4-RD) have recently been obtained. A better understanding of the mechanisms underlying this disease is important for identification of therapeutic targets, which will lead to the development of specific strategies for treatment.Infiltration of activated T follicular helper (Tfh) cells is observed in affected tissues of IgG4-RD. Such Tfh cells have a greater capacity than tonsillar Tfh cells to help B cells produce IgG4. Circulating PD-1CXCR5 peripheral T helper (Tph)-like cells are also increased in patients with IgG4-RD. Because Tph-like cells express high levels of chemokine receptors and granzyme A, they have the capacity to infiltrate affected tissues and exert a cytotoxic function. Tph-like cells can also produce CXCL13, and CXCR5 Tfh cells and B cells are therefore preferentially recruited to form ectopic lymphoid structures in the sites. Tph cells may have a role to ignite inflammation and maintain persistent fibroinflammation in collaboration with Tfh cells in lesions of IgG4-RD.Recent advances in understanding the pathogenesis of IgG4-RD are remarkable. In this review, we summarize and discuss the possible pathologic role of CD4 T-cell subsets in IgG4-RD." @default.
- W2901472882 created "2018-11-29" @default.
- W2901472882 creator A5023093481 @default.
- W2901472882 creator A5044278734 @default.
- W2901472882 creator A5079760792 @default.
- W2901472882 date "2019-01-01" @default.
- W2901472882 modified "2023-10-05" @default.
- W2901472882 title "New insights into IgG4-related disease: emerging new CD4+ T-cell subsets" @default.
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- W2901472882 doi "https://doi.org/10.1097/bor.0000000000000558" @default.
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