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- W2901473950 abstract "The-state-of-the-art bio- and nanotechnology have opened up an avenue to noninvasive liquid biopsy for identifying diseases from biomolecules in bloodstream, especially DNA. In this work, we combined sequence-specific-labeling scheme using mutated clustered regularly interspaced short palindromic repeats associated protein 9 without endonuclease activity (CRISPR/dCas9) and ion concentration polarization (ICP) phenomenon as a mechanism to selectively preconcentrate targeted DNA molecules for rapid and direct detection. Theoretical analysis on ICP phenomenon figured out a critical mobility, elucidating two distinguishable concentrating behaviors near a nanojunction, a stacking and a propagating behavior. Through the modulation of the critical mobility to shift those behaviors, the C-C chemokine receptor type 5 ( CCR5) sequences were optically detected without PCR amplification. Conclusively, the proposed dCas9-mediated genetic detection methodology based on ICP would provide rapid and accurate micro/nanofluidic platform of liquid biopsies for disease diagnostics." @default.
- W2901473950 created "2018-11-29" @default.
- W2901473950 creator A5014776088 @default.
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- W2901473950 date "2018-11-13" @default.
- W2901473950 modified "2023-10-17" @default.
- W2901473950 title "dCas9-mediated Nanoelectrokinetic Direct Detection of Target Gene for Liquid Biopsy" @default.
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- W2901473950 doi "https://doi.org/10.1021/acs.nanolett.8b03224" @default.
- W2901473950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30421614" @default.
- W2901473950 hasPublicationYear "2018" @default.
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