Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901474773> ?p ?o ?g. }
- W2901474773 endingPage "902" @default.
- W2901474773 startingPage "893" @default.
- W2901474773 abstract "Aims To investigate the prevalence of adult‐onset autoimmune diabetes (ADM) and predisposition to autoimmune diseases by quantifying serum organ‐specific autoantibodies in people with phenotype of type 2 diabetes (T2D). Materials and methods We included a nationally representative sample of 46 239 adults aged ≥20 years from 14 provinces, of whom 4671 had diabetes, plus 1000 control subjects with normal glucose tolerance (NGT). Participants were screened centrally for autoantibodies to glutamic acid decarboxylase (GAD), islet antigen 2 (IA2) and zinc transporter isoform‐8 (Znt8) and were defined as having ADM where positive for these antibodies. We then assayed thyroid peroxidase (TPO), tissue transglutaminase (tTG) and 21‐hydroxylase (21‐OH) autoantibodies in randomly selected participants with ADM and in age‐matched, sex‐matched and non‐ADM controls with T2D plus controls with NGT. Results Post‐normalization, the standardized prevalence rate of ADM was 6.0% (95% confidence interval [CI] 5.3‐6.8) in initially non‐insulin‐requiring participants with ADM, corresponding to six million adults in China, in whom adjusted antibody positivity was: TPO autoantibodies 16.3% (95% CI 10.8‐21.8), tTG autoantibodies 2.1% (95% CI 0.0‐4.2), and 21‐OH autoantibodies 1.8% (95% CI ‐0.2 to 3.8). Those participants with ADM who were GAD autoantibody‐positive had high risk of TPO autoantibody positivity (odds ratio [OR] 2.39, P = 0.0031) and tTG autoantibody positivity (OR 6.98, P = 0.027), while those positive for IA2 autoantibodies had a high risk of tTG autoantibody positivity (OR 19.05, P = 0.001). Conclusions A proportion of people with phenotype of T2D in China have ADM, with diabetes‐associated autoantibodies, and may be at risk of developing other organ‐specific autoimmune diseases; therefore, it may be clinically relevant to consider screening such Chinese populations." @default.
- W2901474773 created "2018-11-29" @default.
- W2901474773 creator A5007251193 @default.
- W2901474773 creator A5012775407 @default.
- W2901474773 creator A5012799196 @default.
- W2901474773 creator A5022642009 @default.
- W2901474773 creator A5023624619 @default.
- W2901474773 creator A5029627298 @default.
- W2901474773 creator A5034676224 @default.
- W2901474773 creator A5036445163 @default.
- W2901474773 creator A5036949656 @default.
- W2901474773 creator A5037441262 @default.
- W2901474773 creator A5037989560 @default.
- W2901474773 creator A5039395009 @default.
- W2901474773 creator A5046606444 @default.
- W2901474773 creator A5049407947 @default.
- W2901474773 creator A5051839885 @default.
- W2901474773 creator A5052194166 @default.
- W2901474773 creator A5052325974 @default.
- W2901474773 creator A5055675142 @default.
- W2901474773 creator A5055845931 @default.
- W2901474773 creator A5063519364 @default.
- W2901474773 creator A5069771802 @default.
- W2901474773 creator A5076079188 @default.
- W2901474773 creator A5079650987 @default.
- W2901474773 creator A5083581289 @default.
- W2901474773 creator A5083822183 @default.
- W2901474773 creator A5085352453 @default.
- W2901474773 creator A5085639572 @default.
- W2901474773 date "2018-12-25" @default.
- W2901474773 modified "2023-10-18" @default.
- W2901474773 title "Identification of autoimmune type 1 diabetes and multiple organ‐specific autoantibodies in adult‐onset non‐insulin‐requiring diabetes in China: A population‐based multicentre nationwide survey" @default.
- W2901474773 cites W1420585492 @default.
- W2901474773 cites W1888317895 @default.
- W2901474773 cites W1894478766 @default.
- W2901474773 cites W1926395376 @default.
- W2901474773 cites W1962393906 @default.
- W2901474773 cites W1969080742 @default.
- W2901474773 cites W1991909333 @default.
- W2901474773 cites W2001072123 @default.
- W2901474773 cites W2008443993 @default.
- W2901474773 cites W2053369310 @default.
- W2901474773 cites W2063535379 @default.
- W2901474773 cites W2092847594 @default.
- W2901474773 cites W2098739800 @default.
- W2901474773 cites W2101743642 @default.
- W2901474773 cites W2101906420 @default.
- W2901474773 cites W2110009838 @default.
- W2901474773 cites W2115209313 @default.
- W2901474773 cites W2130266732 @default.
- W2901474773 cites W2148821930 @default.
- W2901474773 cites W2155379679 @default.
- W2901474773 cites W2167932618 @default.
- W2901474773 cites W2178912829 @default.
- W2901474773 cites W2218618842 @default.
- W2901474773 cites W2236334407 @default.
- W2901474773 cites W2269829209 @default.
- W2901474773 cites W2308711820 @default.
- W2901474773 cites W2398141956 @default.
- W2901474773 cites W2510668456 @default.
- W2901474773 cites W2562354979 @default.
- W2901474773 cites W2605486562 @default.
- W2901474773 cites W2606216134 @default.
- W2901474773 cites W2795905061 @default.
- W2901474773 cites W616649672 @default.
- W2901474773 doi "https://doi.org/10.1111/dom.13595" @default.
- W2901474773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30471182" @default.
- W2901474773 hasPublicationYear "2018" @default.
- W2901474773 type Work @default.
- W2901474773 sameAs 2901474773 @default.
- W2901474773 citedByCount "24" @default.
- W2901474773 countsByYear W29014747732019 @default.
- W2901474773 countsByYear W29014747732020 @default.
- W2901474773 countsByYear W29014747732021 @default.
- W2901474773 countsByYear W29014747732022 @default.
- W2901474773 countsByYear W29014747732023 @default.
- W2901474773 crossrefType "journal-article" @default.
- W2901474773 hasAuthorship W2901474773A5007251193 @default.
- W2901474773 hasAuthorship W2901474773A5012775407 @default.
- W2901474773 hasAuthorship W2901474773A5012799196 @default.
- W2901474773 hasAuthorship W2901474773A5022642009 @default.
- W2901474773 hasAuthorship W2901474773A5023624619 @default.
- W2901474773 hasAuthorship W2901474773A5029627298 @default.
- W2901474773 hasAuthorship W2901474773A5034676224 @default.
- W2901474773 hasAuthorship W2901474773A5036445163 @default.
- W2901474773 hasAuthorship W2901474773A5036949656 @default.
- W2901474773 hasAuthorship W2901474773A5037441262 @default.
- W2901474773 hasAuthorship W2901474773A5037989560 @default.
- W2901474773 hasAuthorship W2901474773A5039395009 @default.
- W2901474773 hasAuthorship W2901474773A5046606444 @default.
- W2901474773 hasAuthorship W2901474773A5049407947 @default.
- W2901474773 hasAuthorship W2901474773A5051839885 @default.
- W2901474773 hasAuthorship W2901474773A5052194166 @default.
- W2901474773 hasAuthorship W2901474773A5052325974 @default.
- W2901474773 hasAuthorship W2901474773A5055675142 @default.
- W2901474773 hasAuthorship W2901474773A5055845931 @default.
- W2901474773 hasAuthorship W2901474773A5063519364 @default.
- W2901474773 hasAuthorship W2901474773A5069771802 @default.