FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2901474795> ?p ?o ?g. }

• W2901474795 abstract "Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-B signaling. Structural data and in vitro assays have suggested that CARD11 acts as a seed that nucleates the assembly of BCL10 filaments, but the relevance of these findings for CBM complex assembly in cell remains unresolved. To uncouple cellular CARD11 recruitment of BCL10 and BCL10 filament assembly, we generated a BCL10-CARD11 fusion protein that links the C-terminus of BCL10 to the N-terminus of CARD11. When stably expressed in CARD11 KO Jurkat T cells, the BCL10-CARD11 fusion induced constitutive MALT1 activation. Furthermore, in CARD11 KO BJAB B cells, BCL10-CARD11 promoted constitutive NF-B activation to a similar extent as CARD11 containing oncogenic driver mutations. Using structure-guided destructive mutations in the CARD11-BCL10 (CARD11 R35A) or BCL10-BCL10 (BCL10 R42E) interfaces, we demonstrate that chronic activation by the BCL10-CARD11 fusion protein was independent of the CARD11 CARD. However, activation strictly relied upon the ability of the BCL10 CARD to form oligomers. Thus, by combining distinct CARD mutations in the context of constitutively active BCL10-CARD11 fusion proteins, we provide evidence that BCL10-MALT1 recruitment to CARD11 and BCL10 filament formation are interconnected processes, which bridge the CARD11 seed to downstream pathways in lymphocytes." @default.
• W2901474795 created "2018-11-29" @default.
• W2901474795 creator A5005406926 @default.
• W2901474795 creator A5011109417 @default.
• W2901474795 creator A5037449717 @default.
• W2901474795 creator A5037927181 @default.
• W2901474795 creator A5039567285 @default.
• W2901474795 creator A5049334425 @default.
• W2901474795 creator A5075891140 @default.
• W2901474795 creator A5091410216 @default.
• W2901474795 date "2018-11-20" @default.
• W2901474795 modified "2023-10-05" @default.
• W2901474795 title "BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation" @default.
• W2901474795 cites W1621883807 @default.
• W2901474795 cites W1894912312 @default.
• W2901474795 cites W1969929211 @default.
• W2901474795 cites W1976855961 @default.
• W2901474795 cites W1977709885 @default.
• W2901474795 cites W1984358344 @default.
• W2901474795 cites W1993526486 @default.
• W2901474795 cites W2016898251 @default.
• W2901474795 cites W2019834631 @default.
• W2901474795 cites W2027515017 @default.
• W2901474795 cites W2029295983 @default.
• W2901474795 cites W2029582401 @default.
• W2901474795 cites W2031169398 @default.
• W2901474795 cites W2031855605 @default.
• W2901474795 cites W2035679764 @default.
• W2901474795 cites W2057751290 @default.
• W2901474795 cites W2064815984 @default.
• W2901474795 cites W2075626786 @default.
• W2901474795 cites W2077756009 @default.
• W2901474795 cites W2086569749 @default.
• W2901474795 cites W2086900079 @default.
• W2901474795 cites W2089424075 @default.
• W2901474795 cites W2093670875 @default.
• W2901474795 cites W2096607360 @default.
• W2901474795 cites W2096977835 @default.
• W2901474795 cites W2098549833 @default.
• W2901474795 cites W2115399372 @default.
• W2901474795 cites W2120368369 @default.
• W2901474795 cites W2138141169 @default.
• W2901474795 cites W2143086969 @default.
• W2901474795 cites W2150955780 @default.
• W2901474795 cites W2154321224 @default.
• W2901474795 cites W2159460252 @default.
• W2901474795 cites W2169810209 @default.
• W2901474795 cites W2170852908 @default.
• W2901474795 cites W2197237426 @default.
• W2901474795 cites W2257747161 @default.
• W2901474795 cites W2284339351 @default.
• W2901474795 cites W2319616587 @default.
• W2901474795 cites W2338409690 @default.
• W2901474795 cites W2343854511 @default.
• W2901474795 cites W2406958043 @default.
• W2901474795 cites W2474113206 @default.
• W2901474795 cites W2535072167 @default.
• W2901474795 cites W2739882956 @default.
• W2901474795 cites W2786222364 @default.
• W2901474795 cites W2893499847 @default.
• W2901474795 cites W4254666598 @default.
• W2901474795 doi "https://doi.org/10.3389/fimmu.2018.02695" @default.
• W2901474795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6255920" @default.
• W2901474795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30515170" @default.
• W2901474795 hasPublicationYear "2018" @default.
• W2901474795 type Work @default.
• W2901474795 sameAs 2901474795 @default.
• W2901474795 citedByCount "10" @default.
• W2901474795 countsByYear W29014747952019 @default.
• W2901474795 countsByYear W29014747952020 @default.
• W2901474795 countsByYear W29014747952021 @default.
• W2901474795 countsByYear W29014747952022 @default.
• W2901474795 countsByYear W29014747952023 @default.
• W2901474795 crossrefType "journal-article" @default.
• W2901474795 hasAuthorship W2901474795A5005406926 @default.
• W2901474795 hasAuthorship W2901474795A5011109417 @default.
• W2901474795 hasAuthorship W2901474795A5037449717 @default.
• W2901474795 hasAuthorship W2901474795A5037927181 @default.
• W2901474795 hasAuthorship W2901474795A5039567285 @default.
• W2901474795 hasAuthorship W2901474795A5049334425 @default.
• W2901474795 hasAuthorship W2901474795A5075891140 @default.
• W2901474795 hasAuthorship W2901474795A5091410216 @default.
• W2901474795 hasBestOaLocation W29014747951 @default.
• W2901474795 hasConcept C104317684 @default.
• W2901474795 hasConcept C107006841 @default.
• W2901474795 hasConcept C179464577 @default.
• W2901474795 hasConcept C19317047 @default.
• W2901474795 hasConcept C2776090121 @default.
• W2901474795 hasConcept C54355233 @default.
• W2901474795 hasConcept C86803240 @default.
• W2901474795 hasConcept C8891405 @default.
• W2901474795 hasConcept C95444343 @default.
• W2901474795 hasConceptScore W2901474795C104317684 @default.
• W2901474795 hasConceptScore W2901474795C107006841 @default.
• W2901474795 hasConceptScore W2901474795C179464577 @default.
• W2901474795 hasConceptScore W2901474795C19317047 @default.
• W2901474795 hasConceptScore W2901474795C2776090121 @default.
• W2901474795 hasConceptScore W2901474795C54355233 @default.
• W2901474795 hasConceptScore W2901474795C86803240 @default.
• W2901474795 hasConceptScore W2901474795C8891405 @default.

• next