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- W2901475185 endingPage "903" @default.
- W2901475185 startingPage "893" @default.
- W2901475185 abstract "The proepicardium (PE) is a transitory extracardiac embryonic structure which plays a crucial role in cardiac morphogenesis and delivers various cell lineages to the developing heart. The PE arises from the lateral plate mesoderm (LPM) and is present in all vertebrate species. During development, mesothelial cells of the PE reach the naked myocardium either as free-floating aggregates in the form of vesicles or via a tissue bridge; subsequently, they attach to the myocardium and, finally, form the third layer of a mature heart-the epicardium. After undergoing epithelial-to-mesenchymal transition (EMT) some of the epicardial cells migrate into the myocardial wall and differentiate into fibroblasts, smooth muscle cells, and possibly other cell types. Despite many recent findings, the molecular pathways that control not only proepicardial induction and differentiation but also epicardial formation and epicardial cell fate are poorly understood. Knowledge about these events is essential because molecular mechanisms that occur during embryonic development have been shown to be reactivated in pathological conditions, for example, after myocardial infarction, during hypertensive heart disease or other cardiovascular diseases. Therefore, in this review we intended to summarize the current knowledge about PE formation and structure, as well as proepicardial cell fate in animals commonly used as models for studies on heart development. Anat Rec, 302:893-903, 2019. © 2018 Wiley Periodicals, Inc." @default.
- W2901475185 created "2018-11-29" @default.
- W2901475185 creator A5052810260 @default.
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- W2901475185 creator A5077640001 @default.
- W2901475185 creator A5088161213 @default.
- W2901475185 date "2018-11-29" @default.
- W2901475185 modified "2023-10-12" @default.
- W2901475185 title "Proepicardium: Current Understanding of its Structure, Induction, and Fate" @default.
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